Trihexylphenedyl

The Trihexylphenedyl, with the CAS registry number 144-11-6,is also known as Artane; Benzhexol; 1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol. It belongs to the product categories of API.Its EINECS number is 205-614-4. This chemical's molecular formula is C₂₀H₃₁NO and molecular weight is 301.47. What's more,Its systematic name is Trihexylphenedyl.It is one of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic.It was invented in the United States in 1949, and it has been in clinical usage for decades. Chemically, it is a tertiary amine with alcohol, phenyl, and cyclohexyl moieties. The drug is available as the hydrochloride salt.

Physical properties about Trihexyphenidyl are:
(1)ACD/LogP:  4.391; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  1.37; (4)ACD/LogD (pH 7.4):  2.50; (5)ACD/BCF (pH 5.5):  1.21; (6)ACD/BCF (pH 7.4):  16.34; (7)ACD/KOC (pH 5.5):  5.52; (8)ACD/KOC (pH 7.4):  74.45; (9)#H bond acceptors:  2; (10)#H bond donors:  1; (11)#Freely Rotating Bonds:  6; (12)Index of Refraction:  1.547; (13)Molar Refractivity:  91.847 cm3; (14)Molar Volume:  289.671 cm3; (15)Surface Tension:  43.3380012512207 dyne/cm; (16)Density:  1.041 g/cm3; (17)Flash Point:  210.982 °C; (18)Enthalpy of Vaporization:  74.43 kJ/mol; (19)Boiling Point:  447.852 °C at 760 mmHg; (20)Vapour Pressure:  0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:OC(c1ccccc1)(CCN2CCCCC2)C3CCCCC3;
(2)Std. InChI:InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;
(3)Std. InChIKey:HWHLPVGTWGOCJO-UHFFFAOYSA-N.

Uses of Trihexyphenidyl:
Trihexyphenidyl is used for the symptomatic treatment of Parkinson's disease in mono- and combination therapy. It is active in postencephalitic, arteriosclerotic, and idiopathic forms. The drug is also commonly used to treat extrapyramidal side effects occurring during antipsychotic treatment. It reduces the frequency and duration of oculogyric crises as well as of dyskinetic movements and spastic contractions. Excessive salivation may also respond. Trihexyphenidyl may improve psychotic depression and mental inertia frequently associated with Parkinson's disease and symptomatic problems caused by antipsychotic treatment.
According to a recent news report, trihexyphenidyl has been used recreationally among Iraqi soldiers and police. The report states that the drug, taken in high doses, results in an increased sense of well-being and decreased anxiety. Although the drug is not considered physically addictive, the report suggests that the drug may become habit forming among some users due to its supposed psychological effects.