Trimethoxysilylpropanethiol supplier

Name
Trimethoxysilylpropanethiol
EINECS 224-588-5
CAS No. 4420-74-0
Article Data19
CAS DataBase
Density 0.999 g/cm³
Solubility decomposes in water
Melting Point <-50 °C
Formula C₆H₁₆O₃SSi
Boiling Point 198 °C at 760 mmHg
Molecular Weight 196.343
Flash Point 48.9 °C
Transport Information UN 3082 9/PG 3
Appearance white to light straw liquid clear liquid
Safety 24/25-36/37-61-57
Risk Codes 22-43-51/53
Molecular Structure
Hazard Symbols Xn, N
Synonyms WD 80;Z 6062;3-mercaptopropyl trimethoxysilane;(3-Thiopropyl)trimethoxysilane;(g-Mercaptopropyl)trimethoxysilane;3-(Sulfanylpropyl)trimethoxysilane;3-(Trimethoxysilyl)-1-propanethiol;3-(Trimethoxysilyl)propanethiol;3-(Trimethoxysilyl)propyl mercaptan;3-MPTMS;3-Mercaptopropyltrimethoxylsilane;A 160 (coupling agent);A 189;AZ 6129;DynasylanMTMO;Dynasylan NTNS;GF 70;KBE 803;KBM 803P;KH 590;LS 1390;M 8500 (coupling agent);MPS-M;MPTMS;MPTS;NUCA 189;Prosil 196;SCA 903;SIM 6476.0;SiSiB PC 2300;Sila-Ace S 810;Silan GF 70;Silquest A 189;TSL 8380E;VP-Si 163;
PSA 66.49000
LogP 1.18440

Synthetic route

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With sodium sulfide; tetrabutyl-ammonium chloride; water In toluene at 88 - 92℃; for 4h;	93.5%
With N-octylpyridinium tetrafluoroborate; sodium hydrogen sulfide; triphenylethylphosphonium bromide In water at 48 - 120℃; for 3.5h; Reagent/catalyst; Inert atmosphere;	93.32%
With hydrogen sulfide; sodium In methanol
With hydrogen sulfide; ammonia In methanol
Multi-step reaction with 2 steps 1: dodecyltrimethylphosphonium bromide / methanol / 130 - 140 °C 2: ethylenediamine; sodium methylate / 80 - 90 °C View Scheme

: 51826-90-5
(3-bromopropyl) trimethoxysilane

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
	89.4%
	87.2%

: 870-23-5
prop-2-ene-1-thiol

: 2487-90-3
trimethoxysilane

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
Stage #1: prop-2-ene-1-thiol at 62 - 64℃; for 0.5h; Inert atmosphere; Stage #2: trimethoxysilane In methanol at 72 - 75℃; for 2h; Solvent; Temperature;	88.2%

: 64456-54-8
S-[3-(trimethoxysilyl)propyl] ethanethioate

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With sodium methylate In methanol at 65℃; for 12h;	88%
With sodium methylate In methanol

sodium sulfide anhydride: sodium sulfide anhydride

: 2530-87-2
3-Chloropropyltrimethoxysilan

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With hydrogen sulfide In methanol	79.9%

: 2551-83-9
allyltrimethoxysilane

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With hydrogen sulfide Irradiation;

: 2551-83-9
allyltrimethoxysilane

A: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

B: 35112-74-4
bis-(3-trimethoxysilylpropyl)-disulphide

C: 29055-11-6
bis<3-(trimethoxysilyl)propyl> sulfide

Conditions

Conditions	Yield
With hydrogen sulfide under 760 Torr; for 2.5h; Irradiation; Yield given;

...Expand

: 67-56-1
methanol

: C3H10SSi*TiO2

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With hydrogenchloride In water for 1h;

: N-(trimethoxysilylpropyl)isothiuronium chloride

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

Conditions

Conditions	Yield
With sodium methylate; ethylenediamine at 80 - 90℃;	188 g

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 251091-78-8
3,12-bis-(3,5-dimethylphenyl)carbamoyl-N-allyl-deoxycholan-24-amide

: 3,12-bis-(3,5-dimethylphenyl)carbamoyl-N-(3-trimethoxysilylpropylthio)propyl-deoxycholan-24-amide

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) for 20h; Addition; Heating;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 251091-81-3
3-(3,5-dichlorophenyl)carbamoyl-12-(3,5-dimethylphenyl)carbamoyl-N-allyl-deoxycholan-24-amide

: 3-bis-(3,5-dichlorophenyl)carbamoyl-12-(3,5-dimethylphenyl)carbamoyl-N-(3-trimethoxysilylpropylthio)propyl-deoxycholan-24-amide

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) for 20h; Addition; Heating;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 251091-80-2
3-(3,5-dimethylphenyl)carbamoyl-12-(3,5-dichlorophenyl)carbamoyl-N-allyl-deoxycholan-24-amide

: 3-bis-(3,5-dimethylphenyl)carbamoyl-12-(3,5-dichlorophenyl)carbamoyl-N-(3-trimethoxysilylpropylthio)propyl-deoxycholan-24-amide

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) for 20h; Addition; Heating;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 251091-79-9
3,12-bis-(3,5-dichlorophenyl)carbamoyl-N-allyl-deoxycholan-24-amide

: 3,12-bis-(3,5-dichlorophenyl)carbamoyl-N-(3-trimethoxysilylpropylthio)propyl-deoxycholan-24-amide

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) for 20h; Addition; Heating;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 479623-43-3
N1-{2-[4-(allylamino)-6-{[(1S)-1-(1-naphthyl)ethyl]amino}-1,3,5-triazin-2-yloxy]ethyl}-N2-(3,5-dinitrobenzoyl)leucinamide

: C39H53N9O10SSi

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) In chloroform for 48h; Heating;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 35112-74-4
bis-(3-trimethoxysilylpropyl)-disulphide

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide In dichloromethane at 20℃; for 96h;	100%
With 2,2'-dipyridyldisulphide In dichloromethane at 20℃; for 96h; Inert atmosphere;	79.78%
With bromopentacarbonylmanganese(I); oxygen In benzene at 20℃; for 2h; UV-irradiation; chemoselective reaction;	36%

: 558439-79-5
2-[4-(pent-4-enoxy)phenylcarbamatomethyl]-18-crown-6

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 4-(3-trimethoxysilylpropylthiopentyloxy)phenylcarbamatomethyl-18-crown-6

Conditions

Conditions	Yield
With dibenzoyl peroxide In chloroform for 120h; Heating / reflux;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 77075-58-2
allyl choline phosphate

: C14H34NO7PSSi

Conditions

Conditions	Yield
With benzophenone In ethanol at 20℃; for 0.25h; UV-irradiation; Inert atmosphere;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 1025-15-6
triallyl isocyanurate

: 1,3,5-tris [3-[[3-(trimethoxysilyl)propyl]thio]propyl]isocyanurate

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) at 110℃; for 5h;	100%

: 1005757-37-8
1-allyl-2,3-dimethylimidazolium bis(trifluoromethanesulfonyl)imide

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 1-{3-[(3-(Trimethoxysilyl)propyl)thio]propyl}-2,3-dimethylimidazolium bis(trifluoromethanesulfonyl)amide

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone for 1h; Inert atmosphere; UV-irradiation;	100%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 344303-41-9
4'-but-3-enyl-4-methyl-2,2'-bipyridinyl

: 4'-{4-[3-(trimethoxysilanyl)propylsulfanyl]butyl}-4-methyl-2,2'-bipyridinyl

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) In chloroform for 12h; Heating;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 1443919-53-6
2-methylene-2,3-dihydrothieno[3,4-b][1,4]dioxine

: 1443919-61-6
(3-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methylthio)propyl)trimethoxysilane

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol at 90℃; UV-irradiation;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 106928-50-1
methyl 2-[(tert-butoxycarbonyl)amino]pent-4-enoate

: methyl 3,3-dimethoxy-15,15-dimethyl-13-oxo-2,14-dioxa-7-thia-12-aza-3-silahexadecane-11-carboxylate

Conditions

Conditions	Yield
In ethanol at 60 - 70℃; for 6h; Irradiation;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 655249-87-9
1-allyl-3-methylimidazol-3-ium N-bis(trifluoromethanesulfonyl)imidate

: C13H27N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 1206823-78-0
1-(3-buten-1-yl)-3-methylimidazolium bis(trifluoromethanesulfonyl)imide

: C14H29N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: C10H17N2(1+)*C2F6NO4S2(1-)

: C16H33N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: C11H19N2(1+)*C2F6NO4S2(1-)

: C17H35N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 229162-26-9
1,3,4,6-tetraallyl glycoluril

: 1,3,4,6-tetrakis[3-[[3-(trimethoxysilyl)propyl]thio]propyl]glycoluril

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) at 60℃; for 3h;	99%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 107-13-1
acrylonitrile

: C9H19NO3SSi*C9H19NO3SSi

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In tetrahydrofuran for 0.5h; UV-irradiation;	99%

: 1484-13-5
9-vinyl-9H-carbazole

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 9-(2-((3-(trimethoxysilyl)propyl)thio)ethyl)-9H-carbazole

Conditions

Conditions	Yield
With 1-hydroxycyclohexyl phenyl ketone In tetrahydrofuran for 4h; UV-irradiation;	98%
In neat (no solvent) at 20℃; for 0.5h; UV-irradiation;

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: C9H15N2(1+)*C2F6NO4S2(1-)

: C15H31N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	98%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: allyltriethylammonium bis(trifluoromethanesulfonyl)amide

: C15H36NO3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	98%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 1506-76-9
cyclotricatechylene

: 121-44-8
triethylamine

: C102H90O24S6Si6(6-)*6C6H15N*6H(1+)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; acetonitrile at 100℃; for 24h; Inert atmosphere;	98%

...Expand

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 693-02-7
hex-1-yne

: 1,2-bis[3-(trimethoxysilyl)propylthio]hexane

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone for 0.333333h; Inert atmosphere; UV-irradiation;	97%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: C13H23N2(1+)*C2F6NO4S2(1-)

: C19H39N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	97%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: C14H25N2(1+)*C2F6NO4S2(1-)

: C20H41N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	97%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: C15H27N2(1+)*C2F6NO4S2(1-)

: C21H43N2O3SSi(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	97%

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 1,3-bis(allyl)imidazolium bis(trifluoromethanesulfonyl)imide

: C21H45N2O6S2Si2(1+)*C2F6NO4S2(1-)

Conditions

Conditions	Yield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; dichloromethane at 20℃; for 8h; Inert atmosphere; Sealed tube; UV-irradiation;	97%

: 3194-70-5
2-vinyl-4,6-diamino-S-triazine

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: 2,4-diamino-6-{2-[3-(trimethoxysilyl)propylthio]ethyl}-1,3,5-triazine

Conditions

Conditions	Yield
In methanol at 65℃; for 1h;	97%

: 676257-10-6
N-[2-(methacryloyloxy)ethyl]-N,N,N-trimethylammonium bis(trifluoromethylsulfonyl)imide

: 4420-74-0
3-(trimethoxysilyl)-1-propanethiol

: N-[2-{3-(3-trimethoxysilylpropylthio)-2-methylpropionyloxy}ethyl]-N,N,N-trimethylammonium bis(trifluoromethanesulfonyl)imide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 5h;	96.7%

Trimethoxysilylpropanethiol Chemical Properties

IUPAC Name: 3-Trimethoxysilylpropane-1-thiol
Synonyms of Trimethoxysilylpropanethiol (CAS NO.4420-74-0): (3-Mercaptopropyl)trimethoxysilane ; (gamma-mercaptopropyl)trimethoxysilane ; 3-(Trimethoxysilyl)propyl mercaptan ; Silane, 3-mercaptopropyltrimethoxy-
CAS NO: 4420-74-0
Molecular Formula: C₆H₁₆O₃SSi
Molecular Weight: 196.34
Molecular Structure:
EINECS: 224-588-5
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 7
Polar Surface Area: 52.99 Å²
Index of Refraction: 1.439
Molar Refractivity: 51.69 cm³
Molar Volume: 196.4 cm³
Surface Tension: 25.3 dyne/cm
Density: 0.999 g/cm³
Flash Point: 48.9 °C
Enthalpy of Vaporization: 41.64 kJ/mol
Boiling Point: 198 °C at 760 mmHg
Vapour Pressure: 0.518 mmHg at 25°C
Melting Point: <-50°C
Storage temp: 2-8°C
Water Solubility: decomposes
Sensitive: Air & Moisture Sensitive
Stability: Stable, but moisture sensitive - may decomposes on exposure to moist air. Incompatible with water, alcohols, strong oxidizing agents, strong acids.
Appearance: Water white to light straw liquid clear liquid
Product Categories of Trimethoxysilylpropanethiol (CAS NO.4420-74-0): Industrial/Fine Chemicals;Mercapto;Chloroalkylsilanes, etc. (Silane Coupling Agents);Functional Materials;Si (Classes of Silicon Compounds);Silane Coupling Agents;Si-O Compounds;Trialkoxysilanes;Adhesion Promoters;Coupling Agents;Mecapto Silanes;Surface Modifiers

Trimethoxysilylpropanethiol Uses

Trimethoxysilylpropanethiol (CAS NO.4420-74-0) is used in rubber, plastic, glass fibers, coatings, adhesives and sealants products.

Trimethoxysilylpropanethiol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	633mg/kg (633mg/kg)	Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 229, Pg. 1011, 1976.
rabbit	LD50	skin	2140uL/kg (2.14mL/kg)	Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 15, Pg. 261, 1996.
rat	LD50	oral	730uL/kg (0.73mL/kg)	Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 15, Pg. 261, 1996.

Trimethoxysilylpropanethiol Consensus Reports

Reported in EPA TSCA Inventory.

Trimethoxysilylpropanethiol Safety Profile

Safety Information about Trimethoxysilylpropanethiol (CAS NO.4420-74-0):
Hazard Codes: Harmful Xn, Dangerous N
Risk Statements: 22-43-51/53
R22: Harmful if swallowed.
R43: May cause sensitization by skin contact.
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 24/25-36/37-61-57
S24/25: Avoid contact with skin and eyes.
S36/37: Wear suitable protective clothing and gloves.
S57: Use appropriate container to avoid environmental contamination.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3082 9/PG 3
WGK Germany: 2
RTECS: TZ7800000
F: 1-10-13
TSCA: Yes
HazardClass: 9
PackingGroup: III
HS Code: 29310095
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. A skin irritant. When heated to decomposition it emits toxic fumes of SO_x. See also MERCAPTANS and SILANE.

Trimethoxysilylpropanethiol Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible liquid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage: Keep away from heat and flame. Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container..

Product Name

Trimethoxysilylpropanethiol

Synthetic route

Trimethoxysilylpropanethiol Chemical Properties

Trimethoxysilylpropanethiol Uses

Trimethoxysilylpropanethiol Toxicity Data With Reference

Trimethoxysilylpropanethiol Consensus Reports

Trimethoxysilylpropanethiol Safety Profile

Trimethoxysilylpropanethiol Specification

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