Product Name

  • Name

    Trisodium nitrilotriacetate

  • EINECS 225-768-6
  • CAS No. 5064-31-3
  • Density 0.56
  • Solubility 457g/L at 20℃
  • Melting Point 69-71°C(lit.)
  • Formula C6H6NNa3O6
  • Boiling Point 498.2 °C at 760 mmHg
  • Molecular Weight 257.086
  • Flash Point 255.1 °C
  • Transport Information
  • Appearance Clear, straw-colored liquid
  • Safety 36
  • Risk Codes 22-40
  • Molecular Structure Molecular Structure of 5064-31-3 (Trisodium nitrilotriacetate)
  • Hazard Symbols HarmfulXn
  • Synonyms Aceticacid, nitrilotri-, trisodium salt (8CI);Glycine, N,N-bis(carboxymethyl)-,trisodium salt (9CI);A 92R;Chelest 70;Chelest 700;Chemcolox 365 Powder;Clewat C 3;Dissolvine A 40;Dissolvine A 92;Hampshire NTA 150;Masquol NP140;NTA sodium salt;NTA trisodium salt;Syntron A;Trilon A;Trilon A 50;Trilon A 92;Trilon A 92R;Trisodium2,2',2''-nitrilotriacetate;Trisodium NTA;VerseneNTA 148;Versene NTA 150;Versene NTA 335;
  • PSA 123.63000
  • LogP -5.46190

Synthetic route

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

silver nitrate

silver nitrate

nitrilotriacetic acid, silver salt

nitrilotriacetic acid, silver salt

Conditions
ConditionsYield
In water95%
fac-bis(tetraethylammonium)tribromidotricarbonylrhenate

fac-bis(tetraethylammonium)tribromidotricarbonylrhenate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

[NEt4]0.3Na1.7[Re(nitrilotriacetato)(CO)3]

[NEt4]0.3Na1.7[Re(nitrilotriacetato)(CO)3]

Conditions
ConditionsYield
In water ligand salt added to a soln. of Re complex, stirred at 80°C for 2.5 h; evapd. (vac.), washed (CH2Cl2, CHCl3); elem. anal.;85.6%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

Cu2(phenanthroline)3(μ-nitrilotriacetate)*2H2O

Cu2(phenanthroline)3(μ-nitrilotriacetate)*2H2O

Conditions
ConditionsYield
In methanol; water to Cu-compd. in H2O Na-compd. and phenanthroline in H2O-CH3OH added, stirred, heated at reflux for 5 h, cooled to room temp.; filtered, stored for one week, elem. anal.;78%
...Expand
copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

samarium(III) chloride hexahydrate

samarium(III) chloride hexahydrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

[CuCl(nitrilotriacetate)Sm(H2O)6]ClO4*H2O

[CuCl(nitrilotriacetate)Sm(H2O)6]ClO4*H2O

Conditions
ConditionsYield
In water aq. soln. of Na-salt (2 equiv.) added to aq. soln. of Cu-salt, aq. soln.of the rare-earth metal salt added dropwise, mixt. refluxed for 1 h; allowed to cool to room temp., soln. filtered, filtrate stored in desiccator over CaCl2 for 2 weeks; elem. anal.;65%
...Expand
fac-[ReBr3(CO)2(NO)]NEt4

fac-[ReBr3(CO)2(NO)]NEt4

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

NEt4[Re(nitrilotriacetato)(CO)(NO)]

NEt4[Re(nitrilotriacetato)(CO)(NO)]

Conditions
ConditionsYield
In methanol; water byproducts: CO; ligand salt added to a soln. of Re complex, stirred at 80°C for 19 h; chromd. (H2O, H2O/MeOH, MeOH), dried (N2), extd. (acetone), evapd. (vac.); elem. anal.;58.6%
...Expand
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

aqua(nitrilotriacetato)(1,10-phenanthroline)iron(III) monohydrate
427884-20-6

aqua(nitrilotriacetato)(1,10-phenanthroline)iron(III) monohydrate

Conditions
ConditionsYield
In methanol; water soln. 1,10-phenanthroline (1 mol) in MeOH added slowly to soln. FeCl3*6H2O (1 mol) in MeOH followed by aq. soln. sodium nitrilotriacetate (1 mol); slow evapn. at room temp. 3 wk; crystals filtered off; washed (H2O); dried in air; elem. anal.;25%
...Expand
trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

iminodiacetic acid disodium salt

iminodiacetic acid disodium salt

Conditions
ConditionsYield
With triethanolamine
trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

copper hydroxide
20427-59-2

copper hydroxide

4Na(1+)*{Cu(N(CH2COO)3)2}(4-)*4H2O=Na4{Cu(N(CH2COO)3)2}*4H2O

4Na(1+)*{Cu(N(CH2COO)3)2}(4-)*4H2O=Na4{Cu(N(CH2COO)3)2}*4H2O

Conditions
ConditionsYield
With H2O In water heating of an aq. soln. of Na3N(CH2COO)3 and an excess of Cu(OH)2;; filtration; concn. of filtrate; addn. of alc.;;
iron perchlorate hexahydrate

iron perchlorate hexahydrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

diaqua(nitrilotriacetate)iron(III)
58802-76-9, 67359-33-5

diaqua(nitrilotriacetate)iron(III)

Conditions
ConditionsYield
In water reaction time: 20 min; pptn. washed with water, dried; elem. anal.;
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylenediamine
107-15-3

ethylenediamine

{CoC6H6NO6en}*H2O
148978-64-7

{CoC6H6NO6en}*H2O

Conditions
ConditionsYield
With H2O2 In water
...Expand
lanthanum(III) perchlorate

lanthanum(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

La(nitrilotriacetate)2(3-)

La(nitrilotriacetate)2(3-)

Conditions
ConditionsYield
In perchloric acid La salt in aq. HClO4 mixed with aq. soln. of ligand (molar ratio 1:2, pH9.44); not isolated; detd. by (13)C NMR spectra;
piperidine
110-89-4

piperidine

3,5-Di-tert-butylcatechol
1020-31-1

3,5-Di-tert-butylcatechol

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

iron(III) perchlorate

iron(III) perchlorate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

{piperidinium}2{Fe(N,N-bis(carboxymethyl)glycine)(3,5-di-tert-butylcatecholate)}*DMF
81770-38-9

{piperidinium}2{Fe(N,N-bis(carboxymethyl)glycine)(3,5-di-tert-butylcatecholate)}*DMF

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide stoichiometric mixture of components, anaerobic conditions; elem. anal.;
...Expand
trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

neodymium(III) nitrate
16454-60-7

neodymium(III) nitrate

Nd(nta)*3H2O

Nd(nta)*3H2O

Conditions
ConditionsYield
With water In water reflux; filtration of hot soln.; crystn. by evapn.; washing (hot water); drying in air;
With water In water reflux; filtration of hot soln.; crystn. by evapn.; washing (hot water); drying in air;
trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

lanthanum(III) nitrate

lanthanum(III) nitrate

La(nta)*2H2O

La(nta)*2H2O

Conditions
ConditionsYield
With water In water reflux; filtration of hot soln.; crystn. by evapn.; washing (hot water); drying in air;
With water In water reflux; filtration of hot soln.; crystn. by evapn.; washing (hot water); drying in air;
lanthanum(III) perchlorate

lanthanum(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

La(nitrilotriacetate(3-))
15614-58-1

La(nitrilotriacetate(3-))

Conditions
ConditionsYield
In perchloric acid La salt in aq. HClO4 mixed with aq. soln. of ligand (molar ratio 1:1, pH3.66); not isolated; detd. by (13)C NMR spectra;
yttrium(III) perchlorate

yttrium(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

Y(nitrilotriacetate(3-))
857557-44-9, 15414-25-2

Y(nitrilotriacetate(3-))

Conditions
ConditionsYield
In perchloric acid Y salt in aq. HClO4 mixed with aq. soln. of ligand (molar ratio 1:1, pH 9.32); not isolated; detd. by (13)C NMR spectra;
europium(III) perchlorate

europium(III) perchlorate

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

A

Eu(nitrilotriacetate(3-))2(H2O)(3-)

Eu(nitrilotriacetate(3-))2(H2O)(3-)

B

Eu(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)
911421-23-3, 30776-74-0

Eu(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)

C

Eu(ethylenediaminetetraacetate(4-))(nitrilodiacetate acetic acid(2-))(H2O)(3-)

Eu(ethylenediaminetetraacetate(4-))(nitrilodiacetate acetic acid(2-))(H2O)(3-)

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetate and nitrilotriacetate (molar ratio 1:1:2, pH 8.99); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
europium(III) perchlorate

europium(III) perchlorate

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

A

Eu(nitrilotriacetate(3-))2(H2O)(3-)

Eu(nitrilotriacetate(3-))2(H2O)(3-)

B

Eu(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)
911421-23-3, 30776-74-0

Eu(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)

C

Eu(ethylenediaminetetraacetate(4-))(ethylenediaminetriacetate acetic acid(3-))(H2O)(4-)

Eu(ethylenediaminetetraacetate(4-))(ethylenediaminetriacetate acetic acid(3-))(H2O)(4-)

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetate and nitrilotriacetate (molar ratio 1:10:10, pH 7.40); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
europium(III) perchlorate

europium(III) perchlorate

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

A

Eu(nitrilotriacetate(3-))2(H2O)(3-)

Eu(nitrilotriacetate(3-))2(H2O)(3-)

B

Eu(ethylenediaminetetraacetate(4-))(nitrilodiacetate acetic acid(2-))(H2O)(3-)

Eu(ethylenediaminetetraacetate(4-))(nitrilodiacetate acetic acid(2-))(H2O)(3-)

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetate and nitrilotriacetate (molar ratio 1:1:20, pH 7.40); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
europium(III) perchlorate

europium(III) perchlorate

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

A

[Eu(ethylenediaminetetraacetate)(H2O)3](1-)

[Eu(ethylenediaminetetraacetate)(H2O)3](1-)

B

Eu(ethylenediaminetetraacetate(4-))(nitrilodiacetate acetic acid(2-))(H2O)(3-)

Eu(ethylenediaminetetraacetate(4-))(nitrilodiacetate acetic acid(2-))(H2O)(3-)

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetate and nitrilotriacetate (molar ratio 1:1:2, pH 7.03); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
europium(III) perchlorate

europium(III) perchlorate

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

Eu(nitrilotriacetate(3-))(H2O)5
76147-77-8

Eu(nitrilotriacetate(3-))(H2O)5

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. soln. of ligand (molar ratio 1:1, pH3.60); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
europium(III) perchlorate

europium(III) perchlorate

water
7732-18-5

water

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

Eu(nitrilotriacetate(3-))2(H2O)(3-)

Eu(nitrilotriacetate(3-))2(H2O)(3-)

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. soln. of ligand (molar ratio 1:50, pH 5.00-9.00); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
lanthanum(III) perchlorate

lanthanum(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

La(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)
11067-45-1, 911421-24-4, 30641-82-8

La(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)

Conditions
ConditionsYield
In perchloric acid La salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetate and nitrilotriacetate (molar ratio 1:1:1, pH 9.64-11.12); not isolated; detd. by (13)C NMR spectra;
...Expand
europium(III) perchlorate

europium(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

Eu(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)
911421-23-3, 30776-74-0

Eu(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)

Conditions
ConditionsYield
In perchloric acid Eu salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetate and nitrilotriacetate (molar ratio 1:1:2, pH 11.50 or molar ratio 1:1:20, pH 9.03-11.50 or molar ratio 1:10:10, pH 8.99-11.50); not isolated; detd. by time-resolved laser fluorescence spectroscopy andEXAFS spectra;
...Expand
yttrium(III) perchlorate

yttrium(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

ethylene diamine tetraacetic acid tetrasodium salt
64-02-8, 139-33-3, 150-38-9, 7379-28-4, 17421-79-3, 71705-16-3, 116229-67-5

ethylene diamine tetraacetic acid tetrasodium salt

Y(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)
911421-25-5, 31714-67-7

Y(ethylenediaminetetraacetate(4-))(nitrilotriacetate(3-))(4-)

Conditions
ConditionsYield
In perchloric acid Y salt in aq. HClO4 mixed with aq. solns. of ethylenediaminetetraacetateand nitrilotriacetate (molar ratio 1:1:1, pH 9.60-11.12); not isolated; detd. by (13)C NMR spectra;
...Expand
gallium(III) nitrate

gallium(III) nitrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

Ga(N(CH2COO)3)(H2O)2=Ga(N(CH2COO)3)*2H2O
66035-18-5

Ga(N(CH2COO)3)(H2O)2=Ga(N(CH2COO)3)*2H2O

Conditions
ConditionsYield
In water mixing solns. of Ga-salt and org. compd., mixed soln. heating (water bath), pptn.; ppt. sepn., washing (water slightly acidified to pH 3 with nitric acid),drying to const. weight in thermostat at 50-60°C; elem. anal.; d erivatographic anal.;
indium(III) perchlorate

indium(III) perchlorate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

{In(NTA)2}(3-)

{In(NTA)2}(3-)

Conditions
ConditionsYield
In water In(ClO4)3 mixed with Na3N(CH2COO)3 (1:2);
cerium(III) nitrate hexahydrate

cerium(III) nitrate hexahydrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

cerium nitrilotriacetate cerous nitrilotriacetate

cerium nitrilotriacetate cerous nitrilotriacetate

Conditions
ConditionsYield
In water
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

trisodium nitrilotriacetate
5064-31-3

trisodium nitrilotriacetate

C6H6NO6(3-)*Co(2+)*Na(1+)*5H2O

C6H6NO6(3-)*Co(2+)*Na(1+)*5H2O

Conditions
ConditionsYield
In water at 80℃; for 0.5h;

Trisodium nitrilotriacetate Chemical Properties

MF: C6H6NNa3O6
MW: 257.08
EINECS: 225-768-6 
Mol File: 5064-31-3.mol
CAS DataBase Reference： 5064-31-3(CAS DataBase Reference)
NIST Chemistry Reference： 5064-31-3(NIST)
Synonyms:NITRILOTRIACETIC ACID, TRI NA SALT;NITRILOTRIACETIC ACID TRISODIUM SALT;N,N-BIS[CARBOXYMETHYL]GLYCINE TRISODIUM SALT;NTA TRISODIUM SALT;TRIGLYCOLLAMIC ACID TRISODIUM SALT;TRISODIUM NITRILOTRIACETATE;cheeloxnta-14,-na3;chemcolox365powder
The structure of SODIUM NITRILOTRIACETATE(5064-31-3)  is:

            

Trisodium nitrilotriacetate Uses

SODIUM NITRILOTRIACETATE(5064-31-3) is mainly used as chelating and sequestering agent and builder in synthetic detergents and cleaners.

Trisodium nitrilotriacetate Toxicity Data With Reference

1.   

or-rat:emb 495 µg/plate

   JJATDK    JAT, Journal of Applied Toxicology. 1 (1981),190.
2.   

orl-rat LD50:1100 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),398.
3.   

ipr-rat LD50:254 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),398.
4.   

orl-mus LD50:681 mg/kg

   NCILB*    Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) NIH-NCI-E-C-72-3252 .
5.   

orl-mky LD50:750 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),398.

Trisodium nitrilotriacetate Consensus Reports

SODIUM NITRILOTRIACETATE(5064-31-3)  is reported in EPA TSCA Inventory.

Trisodium nitrilotriacetate Safety Profile

Hazard Codes：  Xn
WGK Germany：  2
RTECS：  MB8400000
Risk Statements：  Toxic in contact with skin；Limited evidence of a carcinogenic effect
Safety Statements：Wear suitable protective clothing
Hazardous Substances Data： 5064-31-3(Hazardous Substances Data)
Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Trisodium nitrilotriacetate Specification

1、Handling and Storage
Storage：Keep containers tightly sealed. Store in a cool dry area. Take precautionary measures against static discharges. Ensure all storage areas are well ventilated.
Handling：Avoid inhalation of dust. Avoid contact with the eyes. Wash hands and face thoroughly after handling and before work breaks, eating, drinking, smoking and using toilet facilities. Avoid dust formation and accumulation.
2、Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

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