-
Name
viloxazine
- EINECS 256-281-7
- CAS No. 46817-91-8
- Article Data8
- CAS DataBase
- Density 1.061 g/cm3
- Solubility
- Melting Point 185-186 ºC
- Formula C13H19 N O3
- Boiling Point 350.5 ºC at 760 mmHg
- Molecular Weight 237.299
- Flash Point 144.3 ºC
- Transport Information
- Appearance
- Safety Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also VILOXAZINE HYDROCHLORIDE.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms (?à)-2-(o-Ethoxyphenoxymethyl)morpholine;2-(2-Ethoxyphenoxymethyl)morpholine; Emovit; Viloxazin; Viloxazine
- PSA 39.72000
- LogP 1.78130
VILOXAZINE Chemical Properties
Product Name: Viloxazine (CAS NO.46817-91-8)
Molecular Formula: C13H19NO3
Molecular Weight: 237.2949g/mol
Mol File: 46817-91-8.mol
Melting Point: 185-186 ºC
Boiling point: 350.5 °C at 760 mmHg
Flash Point: 144.3 °C
Density: 1.061 g/cm3
Surface Tension: 36.7 dyne/cm
Enthalpy of Vaporization: 59.51 kJ/mol
Vapour Pressure: 4.39E-05 mmHg at 25°C
XLogP3-AA: 1.5
H-Bond Donor: 1
H-Bond Acceptor: 4
Rotatable Bond Count: 5
Topological Polar Surface Area: 39.7
Heavy Atom Count: 17
Complexity: 213
Undefined Atom StereoCenter Count: 1
Covalently-Bonded Unit Count: 1
VILOXAZINE Uses
Viloxazine hydrochloride was approved for the treatment of clinical depression.Viloxazine has also been studied for the treatment of alcoholism, with some success.
VILOXAZINE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 60mg/kg (60mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
| mouse | LD50 | oral | 552mg/kg (552mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 27, Pg. 437, 1992. | |
| rat | LD50 | intravenous | 60mg/kg (60mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
| rat | LD50 | oral | 2gm/kg (2000mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
VILOXAZINE Safety Profile
Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also VILOXAZINE HYDROCHLORIDE.
VILOXAZINE Specification
Viloxazine ,its CAS NO. is 46817-91-8,the synonyms is 2-[(2-Ethoxyphenoxy)methyl]morpholine ; 2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine ; Emovit ; Morpholine, 2-((2-ethoxyphenoxy)methyl)- .
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