Product Name

  • Name

    alpha-Cyclopentylmandelic acid

  • EINECS 207-047-8
  • CAS No. 427-49-6
  • Article Data15
  • CAS DataBase
  • Density 1.247 g/cm3
  • Solubility
  • Melting Point 144-150 °C
  • Formula C13H16O3
  • Boiling Point 395.6 °C at 760 mmHg
  • Molecular Weight 220.268
  • Flash Point 207.2 °C
  • Transport Information
  • Appearance white to beige powder
  • Safety 45-36/37/39-26
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 427-49-6 (alpha-Cyclopentylmandelic acid)
  • Hazard Symbols CorrosiveC,IrritantXi
  • Synonyms Mandelicacid, a-cyclopentyl- (6CI,7CI,8CI);Mandelic acid, α-cyclopentyl;2-Cyclopentyl-2-hydroxy-2-(phenyl)acetic acid;Cyclopentylphenylglycolic acid;NSC 96637;a-Cyclopentylmandelic acid;Cyclopentyl-hydroxy-phenyl-acetic acid;α-Cyclopentyl-DL-mandelic Acid;
  • PSA 57.53000
  • LogP 2.14900

Synthetic route

glycopyrronium bromide
596-51-0

glycopyrronium bromide

A

3-hydroxy-1,1-dimethyl pyrrolidinium bromide

3-hydroxy-1,1-dimethyl pyrrolidinium bromide

B

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃;A 3.87 g
B 92%
Benzoylformic acid
611-73-4

Benzoylformic acid

cyclopentylmagnesium bromide
33240-34-5

cyclopentylmagnesium bromide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; for 24.5h;36.4%
Stage #1: Benzoylformic acid; cyclopentylmagnesium bromide In diethyl ether at 0 - 20℃; for 24.5h;
Stage #2: With hydrogenchloride In diethyl ether; water		36.4%
2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester
19833-96-6

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; Inert atmosphere;25%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid ethyl ester
16098-80-9

2-cyclopentyl-2-hydroxy-2-phenylacetic acid ethyl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃;
phenylglyoxylic acid ethyl ester
1603-79-8

phenylglyoxylic acid ethyl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0 - 20 °C
2: KOH / methanol / 20 °C
View Scheme
cyclopentylmagnesium bromide
33240-34-5

cyclopentylmagnesium bromide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0 - 20 °C
2: KOH / methanol / 20 °C
View Scheme
methyl 2-oxo-2-phenylacetate
15206-55-0

methyl 2-oxo-2-phenylacetate

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere
1.2: 10 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere
View Scheme
Cyclozil chloromethacryloyloxymethylate
74240-38-3

Cyclozil chloromethacryloyloxymethylate

A

formaldehyd
50-00-0

formaldehyd

B

2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

C

poly(methacrylic acid)
79-41-4

poly(methacrylic acid)

D

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With potassium chloride In methanol at 24.9℃; Rate constant; Kinetics; Mechanism; different pH values from 298-323 K, different ion strength of KCl solution;
...Expand
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid
64471-45-0

(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With D-tyrosine methyl ester In water; acetonitrile at 0℃; for 4h; Reflux;
Stage #2: With hydrogenchloride In water; toluene at 40℃;		83.4%
With L-Tyr-OMe In acetonitrile Reflux;71%
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 12-epi-strychnine In methanol at 20℃;
Stage #2: With (+)-1-phenylethylamine In ethyl acetate		33.3%
N-{[1-(Benzyl)-3-pyrrolidinyl]methyl}-N-methylamine
91189-05-8

N-{[1-(Benzyl)-3-pyrrolidinyl]methyl}-N-methylamine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

N-(l-benzyl-pvrrolidin-3-vlmethvf)-2-cvclopentvl-2-hvdroxv-N-methyl-2-phenyl-acetamide

N-(l-benzyl-pvrrolidin-3-vlmethvf)-2-cvclopentvl-2-hvdroxv-N-methyl-2-phenyl-acetamide

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In N,N-dimethyl-formamide at 15 - 20℃; for 2h;
Stage #2: N-{[1-(Benzyl)-3-pyrrolidinyl]methyl}-N-methylamine With 4-methyl-morpholine In N,N-dimethyl-formamide at 15 - 20℃; for 1 - 14h;
Stage #3: With water for 0.25h;		75.34%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(3S)-1-benzyl-3-pyrrolidinamine
114715-38-7

(3S)-1-benzyl-3-pyrrolidinamine

2-cyclopentyl-2-hydroxy-N-[(3S)-1-benzyl-pyrrolidin-3-yl]-2-phenylacetamide
719278-59-8

2-cyclopentyl-2-hydroxy-N-[(3S)-1-benzyl-pyrrolidin-3-yl]-2-phenylacetamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;95%
(R)-N-benzyl-3-hydroxypyrrolidine
101385-90-4, 101930-07-8, 101979-03-7, 775-15-5

(R)-N-benzyl-3-hydroxypyrrolidine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(3S)-1-benzylpyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate
719278-61-2

(3S)-1-benzylpyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran at 20℃; for 20h;91%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

[1α,5α,6α]-6-Aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane
134575-10-3

[1α,5α,6α]-6-Aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane

(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide
646035-40-7

(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0 - 20℃;95%
(1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane
720680-79-5

(1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(1α,5α,6α)-N-(3-benzyl-3-azabicyclo[3.1.0]hex-6-ylmethyl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

(1α,5α,6α)-N-(3-benzyl-3-azabicyclo[3.1.0]hex-6-ylmethyl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0 - 20℃;95%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

methyl iodide
74-88-4

methyl iodide

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester
19833-96-6

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;64%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;35%
l-((R)-α-methyl benzyl)-3-pyrrolidin methanol

l-((R)-α-methyl benzyl)-3-pyrrolidin methanol

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(2R,2S)-[(3'R, 3'S)-1'-((R)-α-methvl-benzvl)-pvrrolidin-3'-vlmethvl]-2-hvdroxv-2-cvcopentvl-2-phenvlacetic acid ester

(2R,2S)-[(3'R, 3'S)-1'-((R)-α-methvl-benzvl)-pvrrolidin-3'-vlmethvl]-2-hvdroxv-2-cvcopentvl-2-phenvlacetic acid ester

Conditions
ConditionsYield
Stage #1: l-((R)-α-methyl benzyl)-3-pyrrolidin methanol; 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 4-methyl-morpholine; benzotriazol-1-ol In N,N-dimethyl-formamide at 0 - 5℃; for 1h;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 30℃; for 16h;		17%
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide
186755-46-4

N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In chloroform at 20℃; for 14h;94%
4-(1,5-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butynol

4-(1,5-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butynol

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

4-[(1R,5S)-1,5-dimethyl-3-aza-bicyclo[3.1.0]hex-3-yl]but-2-ynyl-2-cyclopentyl-2-hydroxy phenylacetate

4-[(1R,5S)-1,5-dimethyl-3-aza-bicyclo[3.1.0]hex-3-yl]but-2-ynyl-2-cyclopentyl-2-hydroxy phenylacetate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 60h;
[1α,5α,6α]-6-(N-Methyl)tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hexane
134575-41-0

[1α,5α,6α]-6-(N-Methyl)tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hexane

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

tert-butyl {3-[cyclopentyl(hydroxy)phenylacetyl]-3-azabicyclo [3.1.0]hex-6-yl}methylcarbamate

tert-butyl {3-[cyclopentyl(hydroxy)phenylacetyl]-3-azabicyclo [3.1.0]hex-6-yl}methylcarbamate

Conditions
ConditionsYield
Stage #1: [1α,5α,6α]-6-(N-Methyl)tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hexane; 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 4-methyl-morpholine; benzotriazol-1-ol In N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃;
2-(1H-imidazol-1-yl)ethanamine hydrochloride
154094-97-0

2-(1H-imidazol-1-yl)ethanamine hydrochloride

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

2-cyclopentyl-2-hydroxy-N-[2-(1H-imidazol-1-yl)ethyl]-2-phenylacetamide

2-cyclopentyl-2-hydroxy-N-[2-(1H-imidazol-1-yl)ethyl]-2-phenylacetamide

Conditions
ConditionsYield
Stage #1: 2-(1H-imidazol-1-yl)ethanamine hydrochloride With 4-methyl-morpholine In chloroform at 20℃; for 0.0833333 - 0.166667h;
Stage #2: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With benzotriazol-1-ol In chloroform at 20℃; for 0.5 - 0.75h;
Stage #3: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-cyclopentylidene-1-phenylacetic acid
126497-27-6

1-cyclopentylidene-1-phenylacetic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 48h; Reflux;81%
With hydrogenchloride In water for 49h; Reflux; Inert atmosphere;63%
With hydrogenchloride In water for 48h; Reflux;
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

C22H32N2O4

C22H32N2O4

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
N,N',N'-trimethylenediamine
142-25-6

N,N',N'-trimethylenediamine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

C18H28N2O2

C18H28N2O2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
benzyl chloride
100-44-7

benzyl chloride

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

C20H22O3

C20H22O3

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With sodium hydroxide In N,N-dimethyl-formamide at 60℃; for 1h;
Stage #2: benzyl chloride In N,N-dimethyl-formamide at 110℃; for 3h;		285 g
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-methylpyrrolidin-3-yl methanesulfonate
91832-73-4

1-methylpyrrolidin-3-yl methanesulfonate

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine
13118-11-1

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 75 - 80℃;30 g
toluene-4-sulfonic acid 1-methylpyrrolidin-3-yl ester
60499-30-1

toluene-4-sulfonic acid 1-methylpyrrolidin-3-yl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine
13118-11-1

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 75 - 80℃;11.5 g
metoclopramide
364-62-5

metoclopramide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

2-chloro-4-{[2-(diethylamino)ethyl]carbamoyl}-5-methoxyanilinium-2-cyclopentyl-2-hydroxy-2-phenylacetate

2-chloro-4-{[2-(diethylamino)ethyl]carbamoyl}-5-methoxyanilinium-2-cyclopentyl-2-hydroxy-2-phenylacetate

Conditions
ConditionsYield
In acetone for 6h; Inert atmosphere; Reflux;80%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide
185030-18-6

N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CHCl3 / 14 h / 20 °C
2: 74 percent / H2 / 20percent Pd(OH)2 / ethanol / 8 h / 760.05 Torr
View Scheme
With sodium hydroxide In ethyl acetate
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone
1246930-41-5

2-cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone

Conditions
ConditionsYield
In acetonitrile at 0 - 20℃; for 2h;
In acetonitrile at 0 - 20℃; for 2h; Inert atmosphere;7.3 g
1-methyl-3-pyrrolidinol
13220-33-2

1-methyl-3-pyrrolidinol

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine
13118-11-1

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole In toluene at 20℃; for 0.5h;
Stage #2: 1-methyl-3-pyrrolidinol In toluene at 20℃;		71%
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 18℃;
Stage #2: 1-methyl-3-pyrrolidinol In N,N-dimethyl-formamide at 18 - 60℃; for 19h; Product distribution / selectivity;
With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 18 - 60℃; for 19h; Inert atmosphere;
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: 1-methyl-3-pyrrolidinol In N,N-dimethyl-formamide at 60℃;		Ca.580 g
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

phenyl cyclopentyl ketone
5422-88-8

phenyl cyclopentyl ketone

Conditions
ConditionsYield
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;93%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

cyclopentylphenylmethanol
110480-94-9, 4397-01-7

cyclopentylphenylmethanol

Conditions
ConditionsYield
With sodium tetrahydroborate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; oxygen; caesium carbonate In dichloromethane at 40℃; for 40h; Irradiation;92%
3-benzyl-1-methanesulphonyl-3-azabicyclo[3.1.0]hexane

3-benzyl-1-methanesulphonyl-3-azabicyclo[3.1.0]hexane

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(1α,5α)-[3-benzyl-3-azabicyclo[3.1.0]hex-1-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylcarboxylic ester

(1α,5α)-[3-benzyl-3-azabicyclo[3.1.0]hex-1-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylcarboxylic ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene for 2h; Heating / reflux;

alpha-Cyclopentylmandelic acid Specification

The Benzeneacetic acid, a-cyclopentyl-a-hydroxy-, with the CAS registry number 427-49-6, is also known as α-Cyclopentylmandelic acid. Its EINECS number is 207-047-8. This chemical's molecular formula is C13H16O3 and formula weight is 220.26. What's more, its IUPAC name is 2-cyclopentyl-2-hydroxy-2-phenylacetic acid. Its systematic name is Cyclopentylphenylglycolic acid.

Physical properties of Benzeneacetic acid, a-cyclopentyl-a-hydroxy- are: (1)ACD/LogP: 2.77 ; (2)ACD/LogD (pH 5.5): 0.34; (3)ACD/LogD (pH 7.4): -0.89; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 2.84; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 35.53 Å2; (12)Index of Refraction: 1.589; (13)Molar Refractivity: 59.52 cm3; (14)Molar Volume: 176.5 cm3; (15)Surface Tension: 55.3 dyne/cm; (16)Density: 1.247 g/cm3; (17)Flash Point: 207.2 °C; (18)Enthalpy of Vaporization: 68.11 kJ/mol; (19)Boiling Point: 395.6 °C at 760 mmHg; (20)Vapour Pressure: 5.73E-07 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
It can cause burns. In case of contact with eyes, you need rinse immediately with plenty of water and seek medical advice. When using it, you should wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CCC(C1)C(C2=CC=CC=C2)(C(=O)O)O
(2)InChI: InChI=1S/C13H16O3/c14-12(15)13(16,11-8-4-5-9-11)10-6-2-1-3-7-10/h1-3,6-7,11,16H,4-5,8-9H2,(H,14,15)
(3)InChIKey: WFLUEQCOAQCQLP-UHFFFAOYSA-N

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