trans-1,4-Diaminocyclohexane supplier

Name
trans-1,4-Diaminocyclohexane
EINECS 640-403-4
CAS No. 2615-25-0
Article Data14
CAS DataBase
Density 0.939 g/cm³
Solubility
Melting Point 67-72 °C
Formula C₆H₁₄N₂
Boiling Point 199.4 °C at 760 mmHg
Molecular Weight 114.191
Flash Point 80 °C
Transport Information UN 3259 8/PG 2
Appearance off-white to brown crystals or chunks
Safety 26-36/37/39-45
Risk Codes 22-34-20/21/22
Molecular Structure
Hazard Symbols C
Synonyms trans-1,4-Bisaminocyclohexane;trans-1,4-Cyclohexanediamine;1,4-trans-Diaminocyclohexane;
PSA 52.04000
LogP 1.61560

Synthetic route

: 556-48-9
1,4-Cyclohexanediol

A: 2615-25-0
trans-1,4-cyclohexyldiamine

B: 15827-56-2
cis-1,4-cyclohexanediamine

Conditions

Conditions	Yield
With dodecacarbonyl-triangulo-triruthenium; 4,5-bis((diisopropylphosphanyl)methyl)acridine; ammonia In tert-Amyl alcohol at 170℃; for 21h; Temperature; Inert atmosphere; Schlenk technique; Autoclave;	A 64.4% B 35.6%

: 106-50-3
1,4-phenylenediamine

: 2615-25-0
trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
With nickel; methyl cyclohexane at 180℃; under 73550.8 Torr; Hydrogenation;
With 1,4-dioxane; nickel at 180℃; under 110326 Torr; Hydrogenation;
With nickel; decalin at 180℃; under 110326 Torr; Hydrogenation;

: 54657-09-9
trans-1,4-di(carboxamido)cyclohexane

: 2615-25-0
trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
With sodium hydroxide; bromine

: 32175-29-4
trans-1.4-bis-methoxycarbonylamino-cyclohexane

: 2615-25-0
trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
With hydrogenchloride

: 82166-21-0
methyl cyclohexane

: 106-50-3
1,4-phenylenediamine

nickel /kieselguhr: nickel /kieselguhr

: 2615-25-0
trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
at 180℃; under 73550.8 Torr; Hydrogenation;

...Expand

trans-hexahydro-p-phenylenediurethane: trans-hexahydro-p-phenylenediurethane

: 2615-25-0
trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
With hydrogenchloride at 120℃; 7-stdg. Erhitzen;
With hydrogenchloride at 100℃; 24-stdg. Erhitzen;

trans-hexahydroterephthalic acid diazide: trans-hexahydroterephthalic acid diazide

: 2615-25-0
trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
With water nachfolgendes Behandeln mit Wasser unter Druck bei 120grad und Erhitzen des Reaktionsproduktes mit konz.Salzsaeure unter Druck auf 140grad;

: 106-50-3
1,4-phenylenediamine

A: 2615-25-0
trans-1,4-cyclohexyldiamine

B: 15827-56-2
cis-1,4-cyclohexanediamine

C: 6850-65-3
p-hydroxycyclohexylamine

D: 108-91-8
cyclohexylamine

E: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With Ru/Al2O3; water; hydrogen In isopropyl alcohol at 90℃; under 30003 Torr; for 0.75h; Autoclave; Inert atmosphere;

...Expand

: 106-50-3
1,4-phenylenediamine

A: 2615-25-0
trans-1,4-cyclohexyldiamine

B: 15827-56-2
cis-1,4-cyclohexanediamine

Conditions

Conditions	Yield
With Ru/Al2O3; hydrogen In water; isopropyl alcohol at 90℃; under 30003 Torr; for 4h; Solvent; Temperature; Pressure; Autoclave; Inert atmosphere;

: 106-50-3
1,4-phenylenediamine

A: 2615-25-0
trans-1,4-cyclohexyldiamine

B: 15827-56-2
cis-1,4-cyclohexanediamine

C: 108-91-8
cyclohexylamine

Conditions

Conditions	Yield
With Ru/Al2O3; hydrogen In water; isopropyl alcohol at 90℃; under 30003 Torr; for 4h; Temperature; Autoclave; Inert atmosphere;

...Expand

: 3114-70-3
trans-1,4-diaminocyclohexane

A: 2615-25-0
trans-1,4-cyclohexyldiamine

B: 15827-56-2
cis-1,4-cyclohexanediamine

Conditions

Conditions	Yield
With 1-methoxy-2-propanol; 5% rhodium on activated aluminium oxide; sodium methylate at 200℃; under 90009 Torr; for 2h; Pressure; Temperature; Inert atmosphere; Autoclave;	A n/a B n/a

: 100-02-7
4-nitro-phenol

A: 2615-25-0
trans-1,4-cyclohexyldiamine

B: 15827-56-2
cis-1,4-cyclohexanediamine

C: 27489-62-9
trans-4-hydroxycyclohexylamine

D: 6850-65-3, 27489-62-9, 40525-78-8
cis-4-aminocyclohexanol

Conditions

Conditions	Yield
With methanol; 5% Rh/C; ammonia; hydrogen; isopropyl alcohol In Hexadecane at 140℃; under 4500.45 Torr; for 3h; Autoclave;	A n/a B n/a C n/a D n/a

...Expand

: 1426953-21-0
[(3R,5S,7R,8R)-7-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(acetyloxy)pent-2-enoyl]amino}-3,6-di-methyltetrahydro-2H-pyran-2-yl]-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro[2.5]oct-5-yl]acetic acid

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 1609106-72-0
(2S,3Z)-5-{[(2R,3R,5S,6S)-6-{(2E,4E)-5-[(3R,4R,5R,7S)-7-{2-[(trans-4-aminocyclohexyl)amino]-2-oxoethyl}-4-hydroxy-1,6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2,4-dien-1-yl}-2,5-dimethyltetrahydro-2H-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate

Conditions

Conditions	Yield
Stage #1: [(3R,5S,7R,8R)-7-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(acetyloxy)pent-2-enoyl]amino}-3,6-di-methyltetrahydro-2H-pyran-2-yl]-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro[2.5]oct-5-yl]acetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: trans-1,4-cyclohexyldiamine With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16.5h;	100%

Yield

Stage #1: [(3R,5S,7R,8R)-7-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(acetyloxy)pent-2-enoyl]amino}-3,6-di-methyltetrahydro-2H-pyran-2-yl]-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro[2.5]oct-5-yl]acetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: trans-1,4-cyclohexyldiamine With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16.5h;

100%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 107-13-1
acrylonitrile

: 3-(4-[(2-cyanoethyl)amino]cyclohexylamino)propanenitrile

Conditions

Conditions	Yield
In methanol at 20℃;	99%
In ethanol at 20℃; for 20h; Michael addition;	82%

: copper(II) choride dihydrate

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 67-68-5
dimethyl sulfoxide

: [CuCl2(trans-1,4-diaminocyclohexane)]*2(dimethylsulfoxide)]

Conditions

Conditions	Yield
In dimethyl sulfoxide mixt. of CuCl2*H2O, C6H10(NH2)2 and small amt. of (CH3)2SO kneaded;	99%
In dimethyl sulfoxide soln. of C6H10(NH2)2 in DMSO added dropwise to soln. of CuCl2*2H2O;	92%

...Expand

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 331-41-9
2-(4-chloro-3-fluorophenoxy)acetic acid

: 2-(4-chloro-3-fluorophenoxy)-N-[(1R,4R)-4-[2-(4-chloro-3-fluorophenoxy)acetamido]cyclohexyl]acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	99%

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 2615-25-0
trans-1,4-cyclohexyldiamine

: C20H22N2O4

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	98%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 3-(2-pyridyl)-2,6,7-trichloroquinoxaline

: N-(6,7-dichloro-3-(pyridin-2-yl)-quinoxalin-2-yl)-cyclohexane-1,4-diamine

Conditions

Conditions	Yield
In toluene for 16h; Heating;	98%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 7517-19-3
methyl (L)-leucinate hydrochloride

: N,N'-di{4-chloro-6-[(2S)-methoxycarbonyl-4-methylbutylamino]-1,3,5-triazine-2-yl}1,4-cyclohexanediamine

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; methyl (L)-leucinate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.5h; Stage #2: trans-1,4-cyclohexyldiamine at 20℃;	98%

...Expand

: 75-15-0
carbon disulfide

: 18937-79-6
methyl 2-hexynoate

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 2,3-dihydro-3-((1r,4r)-4-(4-oxo-6-propyl-2-thioxo-2H-1,3-thiazin-3(4H)-yl)cyclohexyl)-6-propyl-2-thioxo-1,3-thiazin-4-one

Conditions

Conditions	Yield
In water at 20℃; for 0.166667h; Sonication; Green chemistry;	98%

...Expand

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 622-78-6
Benzyl isothiocyanate

: 1,1'-[(1R,4R)-cyclohexane-1,4-diyl]bis(3-benzylthiourea)

Conditions

Conditions	Yield
In neat (no solvent) at 23℃; for 0.0833333h; Time; Irradiation; Green chemistry;	97.21%

: 37942-07-7
3,5-di-tert-butyl-2-hydroxybenzaldehyde

: 2615-25-0
trans-1,4-cyclohexyldiamine

: C36H54N2O2

Conditions

Conditions	Yield
In methanol for 4h; Inert atmosphere;	97%

: 75-15-0
carbon disulfide

: 24342-04-9
methyl pent-2-ynoate

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 6-ethyl-3-((1r,4r)-4-(6-ethyl-4-oxo-2-thioxo-2H-1,3-thiazin-3(4H)-yl)cyclohexyl)-2,3-dihydro-2-thioxo-1,3-thiazin-4-one

Conditions

Conditions	Yield
In water at 20℃; for 0.166667h; Sonication; Green chemistry;	97%

...Expand

: 15601-44-2, 57427-77-7, 57427-86-8
(Z)-2-phenyl-4-(4-chlorobenzylidene)-5(4H)-oxazolone

: 2615-25-0
trans-1,4-cyclohexyldiamine

: (Z)-3,3'-((1R,4R)-cyclohexane-1,4-diyl)bis[5-((Z)-4-chlorobenzylidene)-2-phenyl-3,5-dihydro-4H-imidazol-4-one]

Conditions

Conditions	Yield
With sodium acetate In ethanol at 80℃; for 0.166667h; Temperature;	97%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 2-([1,1'-biphenyl]-4-yl)-4-methyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazole

: N-{4-[2-((1,1'-biphenyl)-4-yl)-4-methylthiazol-5-yl]-pyrimidin-2-yl}cyclohexane-trans-1,4-diamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃;	97%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 306271-99-8
methyl 4’-(bromomethyl)-[1,1’-biphenyl]-4-carboxylate

: C66H62N2O8

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 90℃; for 24h;	97%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 140633-58-5
3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid

: 1186397-03-4
trans-1,4-di[3β-(4-chlorophenyl)tropane-2β-carbonylamino]cyclohexane

Conditions

Conditions	Yield
Stage #1: 3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 0℃; Inert atmosphere; Stage #2: trans-1,4-cyclohexyldiamine In dichloromethane at 0 - 20℃; Inert atmosphere;	96%

: 41715-31-5
3-tert-butyl-5-methylsalicylaldehyde

: 2615-25-0
trans-1,4-cyclohexyldiamine

: C30H42N2O2

Conditions

Conditions	Yield
In methanol for 4h; Inert atmosphere;	96%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 57-06-7
N-allyl isothiocyanate

: C14H24N4S2

Conditions

Conditions	Yield
In neat (no solvent) at 23℃; for 0.0833333h; Irradiation; Green chemistry;	96%

: 57427-79-9, 57427-88-0, 82309-33-9
(Z)-4-(4-methylbenzylidene)-2-phenyloxazol-5(4H)-one

: 2615-25-0
trans-1,4-cyclohexyldiamine

: (Z)-3,3'-((1R,4R)-cyclohexane-1,4-diyl)bis[5-((Z)-4-methylbenzylidene)-2-phenyl-3,5-dihydro-4H-imidazol-4-one]

Conditions

Conditions	Yield
With sodium acetate In ethanol at 80℃; for 0.166667h; Temperature;	96%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: C17H24Cl2N4OSi

: C23H37ClN6OSi

Conditions

Conditions	Yield
In butan-1-ol at 140℃; for 4h;	96%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 181760-12-3
5-chloro-2-cyanoaminopyrimidine

: N-(5-Chloro-pyrimidin-2-yl)-N'-{4-[N'-(5-chloro-pyrimidin-2-yl)-guanidino]-cyclohexyl}-guanidine

Conditions

Conditions	Yield
In butan-1-ol at 90℃; for 4h;	95%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 295796-57-5
9,9’-dihexylfluorene-2,7-dicarbaldehyde

polymer, MW = 4216 g mol-1, degree of polymerization DPn = 9, DPmax = 14; monomer(s): 9,9-dihexyl-9H-fluorene-2,7-dicarbaldehyde; trans-1,4-cyclohexyldiamine: polymer, MW = 4216 g mol-1, degree of polymerization DPn = 9, DPmax = 14; monomer(s): 9,9-dihexyl-9H-fluorene-2,7-dicarbaldehyde; trans-1,4-cyclohexyldiamine

Conditions

Conditions	Yield
In ethanol for 12h; Heating;	95%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 17606-70-1
(4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one

: (Z)-3,3'-((1R,4R)-cyclohexane-1,4-diyl)bis-[5-((Z)-benzylidene)-2-phenyl-3,5-dihydro-4H-imidazol-4-one]

Conditions

Conditions	Yield
With sodium acetate In ethanol at 80℃; for 0.166667h; Temperature;	95%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 2615-25-0
trans-1,4-cyclohexyldiamine

: C42H46N2O8

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 90℃; for 24h;	95%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 4-O-[(2,4,6-triisopropylphenyl)sulfonyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine

: 776297-85-9
N4-(trans-4-aminocyclohexyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxycytidine

Conditions

Conditions	Yield
In ethanol at 60℃; for 1h;	94%

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 81136-42-7
4-chloro-6-ethylthieno<2,3-d>pyrimidine

: 1388891-97-1
C14H20N4S

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 30℃; Product distribution / selectivity;	94%

: 588-20-5
4-chloro-3-methylphenoxyacetic acid

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 2-(4-chloro-3-methylphenoxy)-N-[(1R,4R)-4-[2-(4-chloro-3-methylphenoxy)acetamido]cyclohexyl]acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	94%

: 588-22-7
(3,4-dichlorophenoxy)acetic acid

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 2-(3,4-dichlorophenoxy)-N-[(1R,4R)-4-[2-(3,4-dichlorophenoxy)-acetamido]cyclohexyl]acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	94%

: 119-61-9
benzophenone

: 2615-25-0
trans-1,4-cyclohexyldiamine

: N-benzylidenecyclohexane-1,4-diamine

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate; orthoformic acid triethyl ester In 5,5-dimethyl-1,3-cyclohexadiene for 7h; Reagent/catalyst; Solvent; Reflux;	93.1%

: 5497-67-6
2,2-dimethyl-4-pentenal

: 2615-25-0
trans-1,4-cyclohexyldiamine

: trans-N1,N4-bis(2,2-dimethylpent-4-enylidene)cyclohexane-1,4-diamine

Conditions

Conditions	Yield
With sodium sulfate In dichloromethane at 0 - 20℃; for 24h; Inert atmosphere; Schlenk technique;	93%

trans-1,4-Diaminocyclohexane Chemical Properties

Molecular Structure of Trans-1,4-Diaminocyclohexane (CAS NO.2615-25-0):

IUPAC Name: Cyclohexane-1,4-diamine
CAS Registry Number: 2615-25-0
Molecular formula: C₆H₁₄N₂
Molecular Weight: 114.19
Melting Point: 67-72 °C
Density: 0.939 g/cm³
Flash Point: 80 °C
Boiling Point: 199.4 °C at 760 mmHg
Index of Refraction: 1.483
Molar Refractivity: 34.77 cm³
Molar Volume: 121.5 cm³
Polarizability: 13.78×10^-24cm³
Surface Tension: 37 dyne/cm
Enthalpy of Vaporization: 43.56 kJ/mol
Vapour Pressure: 0.342 mmHg at 25°C
Appearance: Off-white to brown crystals or chunks
Product Categories: Heterocycles series.

trans-1,4-Diaminocyclohexane Safety Profile

Hazard Codes:
C:
Risk Statements about Trans-1,4-Diaminocyclohexane (CAS NO.2615-25-0):
R22: Harmful if swallowed.
R34: Causes burns.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
F10: Keep under argon.
F34: Sensitive to CO₂.
RIDADR: UN 3259 8/PG 2
WGK Germany: 2
HazardClass: 8
PackingGroup: II

trans-1,4-Diaminocyclohexane Specification

Trans-1,4-Diaminocyclohexane with CAS number of 2615-25-0 is also called for Timtec-bb sbb008553 ; Trans-1,4-cyclohexyldiamine ; Trans-1,4-cyclohexanediamine ; Trans-1,4-diaminocyclohexane ; Trans-hexahydro-1,4-phenylenediamine ; Tran(s)-cyclohexane-1,4-diamine ; Trans-1,4-diaminocyclohexane,99% ; 1,4-Cyclohexanediamine . Some useful information: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

trans-1,4-Diaminocyclohexane

Synthetic route

trans-1,4-Diaminocyclohexane Chemical Properties

trans-1,4-Diaminocyclohexane Safety Profile

trans-1,4-Diaminocyclohexane Specification

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