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S-2765, Chromogenic Substrate for Factor Xa Heparin diagnostic reagents
Composition:
S-2765 is white lyophized powder, stored in vials.
Each vial contains: S-2765 10 mg (about 15 μmol); mannitol 60 mg.
Physical and Chemical Properties:
Synonyms: S-2765, FXa substrate
CAS Number: 115388-96-0
Molecular formula: Z-D-Arg-Gly-Arg-pNA·2HCl
Molecular weight: 714.6 Da
Purity: ≥ 99% (HPLC)
Absorption coefficient: A405nm ≤ 0.120 [L/(g·cm)]
Solubility: > 10 mg/mL (in pure water)
Standard: 10mg and 25mg.
Usage:
Reconstitute the entire contents of a vial, dissolve it with 5mL distilled water to get a solution with concentration of 3 mmol/mL S-2765.
Stability and Storage:
The lyophilized powder of S-2765 could be preserved at 2 to 8℃ for at least 24 months.
The 3 mmol/mL S-2765 solution could be preserved at 2 to 8 ℃ for about 1 month.
S-2765 which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm.
S-2765 is mainly used in anti-FXa activity assay of heparin.
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