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Iron saccharate ferric hydroxide sucrose complex IRON (III) OXIDE, SACCHARATED
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Iron saccharate Usage And Synthesis |
Chemical Properties | Brown solid |
Uses | Semi-synthetic macrolide antibiotic |
Uses | Iron Saccharate has been used to treat iron deficiency and iron deficiency anemia associated with different chronic diseases. |
Brand name | Venofer (Luitpold). |
Clinical Use | Phosphate binder |
Drug interactions | Potentially hazardous interactions with other drugs Antibacterials: reduced absorption of 4-quinolones and tetracyclines. Dimercaprol: avoid concomitant use. Mycophenolate: may significantly reduce absorption of mycophenolate. |
Metabolism | After intravenous infusion, iron sucrose is taken up by the cells of the reticuloendothelial cells, particularly in the liver and spleen. The reticuloendothelial cells gradually separate iron from the iron-sucrose complex. Most absorbed iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin; the remainder is contained within the storage forms, ferritin or haemosiderin, or as myoglobin, with smaller amounts occurring in haem-containing enzymes or in plasma bound to transferrin. Only very small amounts of iron are excreted as the majority released after the destruction of the haemoglobin molecule is re-used. |
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