HOMATROPINE METHYL ...

HOMATROPINE METHYL BROMIDE CAS NO.: 80-49-9

HOMATROPINE METHYL BROMIDE CAS NO.: 80-49-9

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1 Gram

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  • Min.Order :1 Gram
  • Purity: 99%
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Keywords

HOMATROPINE METHYL BROMIDE HOMOLONE 8-METHYLHOMATROPINIUM BROMIDE

Quick Details

  • Appearance:Colorless liquid
  • Application:Synthetic fragrances
  • PackAge:drum
  • ProductionCapacity:10000|Metric Ton|Month
  • Storage:Room temperature
  • Transportation:By Sea/Air/DHL

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HOMATROPINE METHYL BROMIDE Basic information
Product Name: HOMATROPINE METHYL BROMIDE
Synonyms: HOMOLONE;HOMATROPINE METHYL BROMIDE;ESOPIN;DL-HOMATROPINE METHYL BROMIDE;ARKITROPIN;8-METHYLHOMATROPINIUM BROMIDE;N-METHYLHOMATROPINIUM BROMIDE;TROPINIUM METHOBROMIDE MANDELATE
CAS: 80-49-9
MF: C17H24BrNO3
MW: 370.28
EINECS: 201-284-0
Product Categories: Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Alkaloids;Biochemistry;Tropane Alkaloids;EQUIPIN;Other APIs
Mol File: 80-49-9.mol
HOMATROPINE METHYL BROMIDE Structure
 
HOMATROPINE METHYL BROMIDE Chemical Properties
Melting point  192°C
storage temp.  -20°C Freezer
solubility  Freely soluble in water, soluble in ethanol 96 per cent
form  neat
color  White to Off-White
Merck  14,4730
CAS DataBase Reference 80-49-9(CAS DataBase Reference)
EPA Substance Registry System Homatropine methylbromide (80-49-9)
 
Safety Information
Risk Statements  20/21/22
Safety Statements  22-26-36
RIDADR  1544
WGK Germany  3
RTECS  MS9000000
HazardClass  6.1
PackingGroup  III
HS Code  29399990
Toxicity LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)
MSDS Information
 
HOMATROPINE METHYL BROMIDE Usage And Synthesis
Chemical Properties White or almost white, crystalline powder or colourless crystals
Uses Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.
Uses anticholinergic (opthalmic)
Brand name Equipin (Mission); Homapin (Mission).
General Description Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).
Clinical Use Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.

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