Homatropine Hydrobr...

Homatropine Hydrobromide CAS NO.: 51-56-9

Homatropine Hydrobromide CAS NO.: 51-56-9

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1 Gram

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  • Min.Order :1 Gram
  • Purity: 99%
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Keywords

Homatropine Hydrobromide alpha-hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide 1aH,5aH-Tropan-3a-ol, mandelate (ester), hydrobromide

Quick Details

  • Appearance:Colorless liquid
  • Application:Synthetic fragrances
  • PackAge:drum
  • ProductionCapacity:10000|Metric Ton|Month
  • Storage:Room temperature
  • Transportation:By Sea/Air/DHL

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Details:

Homatropine Hydrobromide Usage And Synthesis
Description Homatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 μM. Homatropine (1 μM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 μM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.
Chemical Properties white crystals or crystalline powder
Uses Homatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the pupil.
Uses anticholinergic (opthalmic)
Brand name Isopto Homatropine (Alcon) .
General Description Homatropine hydrobromide,1 H,5 H-tropan-3 -ol mandelate (ester) hydrobromide(Homatrocel), occurs as white crystals or as awhite, crystalline powder that is affected by light. It is solublein water (1:6) and alcohol (1:40), less soluble in chloroform(1:420), and insoluble in ether.
Solutions are incompatible with alkaline substances,which precipitate the free base, and with the commonreagents that precipitate alkaloids. As with atropine, solutionsare sterilized best by filtration through a bacteriologicalfilter.
Clinical Use Homatropine hydrobromide is used topically to paralyzethe ciliary structure of the eye (cycloplegia) and to effectmydriasis. It behaves very much like atropine but is weakerand less toxic. In the eye, it acts more rapidly but less persistentlythan atropine. Dilation of the pupil takes place inabout 15 to 20 minutes, and the action subsides in about24 hours. By using a miotic, such as physostigmine, it ispossible to restore the pupil to normality in a few hours.

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