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Cialis,99% Cialis manufacture 171596-29-5
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of production and life science. Our company is mainly engaged in Phosphorus ligands, Pesticide intermediate, medical intermediate, development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. Our products have been exported to Japan, South Korea, Europe, America and other countries and regions, well received by customers.
The objective of the company is to put quality first and put our customer’s needs first –the satisfaction of our customers is the company’s ultimate goal. Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Wentao a leading chemical supplier, and hope to create a better future with you. Innovation and honesty, we will make common development with the masses of customers at home and abroad hand in hand by our best service.
Drug interactions | Potentially hazardous interactions with other drugs Alpha-blockers: enhanced hypotensive effect - avoid concomitant use. Antibacterials: concentration possibly increased by clarithromycin and erythromycin; concentration reduced by rifampicin - avoid. Antifungals: concentration increased by ketoconazole - avoid; concentration possibly increased by itraconazole. Antivirals: concentration possibly increased by fosamprenavir and indinavir; increased by ritonavir - avoid; increased risk of ventricular arrhythmias with saquinavir - avoid; avoid high doses of tadalafil with telaprevir. Cobicistat: concentration of tadalafil possibly increased - reduce dose of tadalafil. Nicorandil: possibly enhanced hypotensive effect - avoid concomitant use. Nitrates: enhanced hypotensive effect - avoid concomitant use. Riociguat: enhanced hypotensive effect - avoid concomitant use. |
Metabolism | Tadalafil is metabolised in the liver mainly by the cytochrome P450 isoenzyme CYP3A4. The major metabolite, the methylcatechol glucuronide, is inactive. Tadalafil is excreted, mainly as metabolites, in the faeces (61% of the dose), and to a lesser extent the urine (36% of the dose). |
References | # # Roehrborn, C. G., et al. "Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study." Journal of Urology 180.4(2008):1228. Rosano, Giuseppe M. C., et al. "Chronic Treatment with Tadalafil Improves Endothelial Function in Men with Increased Cardiovascular Risk." European Urology 47.2(2005):214-222. |
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