Au nanoparticles are known to be efficient CO oxidation catalysts under ambient conditions. Investigation of the interaction of CO with Au is difficult particularly using Raman spectroscopy. Although indirect, we demonstrate the transfer of electrons from Au to CO by means of surface-enhanced Ra...

SummaryTwo N-(2,6-dimethylphenyl)pyridinedicarboximides were synthesized and evaluated for anticonvulsant properties and neurotoxicity. These compounds were mainly active against maximal electroshock (MES) induced seizures in animal models. In rats dosed orally, N-(2,6-dimethylphenyl-2,3-pyridin...

A series of 2-[(2,6)-dimethylphenyl]benzimidazole analogs displayed strong potential for mutagenicity following metabolic activation in either TA98 or TA100 Salmonella typhimurium strains. The number of revertants was significantly reduced by replacing the 2,6-dimethylphenyl group with a 2,6-dic...

Tris(4-amino-2,6-dimethylphenyl)borane (1), a triarylborane bearing an unsubstituted amino group on all of its aryl substituents, and related triarylboranes were synthesized via Ullmann condensation. The facile dehydration reactions of 1 with benzaldehyde and nitrosobenzene gave tris[4-(benzylid...

Based on the nonlinear Schrödinger equation, we discuss the variation dynamics of the peak intensity of high-order rogue wave with shift parameters theoretically, and reveal a non-derivable transformation point in it. The critical behavior of rogue waves shows that the ultimate cause of the tran...

Density Peak (DPeak) clustering algorithm is not applicable for large scale data, due to two quantities, i.e, ρ and δ, are both obtained by brute force algorithm with complexity O(n2). Thus, a simple but fast DPeak, namely FastDPeak,1  is proposed, which runs in about O(nlog(n)) expected time ...

Approaches to simulate peak time and intensity profiles of compounds in comprehensive two dimensional gas chromatography (GC × GC) were developed, and which are demonstrated for separation of a mixture of saturated and unsaturated fatty acid methyl esters (FAME) using a range of column sets. Th...

Peak capacity (PC) is a key concept in chromatographic analysis, nowadays of great importance for characterising complex separations as a criterion to find the most promising conditions. A theoretical expression for PC estimation can be easily deduced in isocratic elution, provided that the colu...

Gas chromatography–mass spectrometry (GCMS) has been extensively used in complex sample analysis for the high-throughput characterization of volatile and semivolatile compounds. However, the accurate extraction of compound information remains challenging. Here, we present a combined algorithm s...

It is a challenge for peak detection algorithms to detect some low-amplitude peaks and overlapped peaks contaminated by noise. Among of existing peak detection algorithms, the continuous wavelet transform (CWT)-based algorithm is the best. When the Mexican Hat wavelet is selected as the mother w...

Encouraging residential electricity consumers switch from the flat-rate electricity tariff to the peak and off-peak pricing is an important task for demand response management. But are consumers willing to accept the peak and off-peak pricing?-This paper presents the results of a national survey...

The study evaluated the relationship between participants’ abilities to derive mutually entailed relations across arbitrary stimuli and the function of their challenging behavior as indicated in the Questions About Behavior Function (QABF) indirect assessment. Entailed relational abilities were...

Let Ω⊂RN, N≥2, be a bounded domain with an outward power-like peak which is assumed not too sharp in a suitable sense. We consider the Laplacian u↦−Δu in Ω with the Robin boundary condition ∂nu=αu on ∂Ω with ∂n being the outward normal derivative and α>0 being a parameter. We show that fo...

The effect of NPC-14686, a potential anti-inflammatory drug, on cytosolic free Ca2+ levels ([Ca2+]i) in HA22/VGH human hepatoma cells was explored by using fura-2 as a fluorescent Ca2+ indicator. NPC-14686 at concentrations above 10 μM increased [Ca2+]i in a concentration-dependent manner with ...

The effect of NPC-14686, a potential anti-inflammatory drug, on cytosolic free Ca2+ levels ([Ca2+]i) and growth in PC3 human prostate cancer cells was examined by using fura-2 as a fluorescent Ca2+ indicator and WST-1 as a fluorescent growth dye. NPC-14686 at concentrations above 10 μM increase...

The attachment energy (AE) calculations were performed to predict the growth morphology of 2,6-diamino-3,5-dinitropyridine-1-oxide (ANPyO) in vacuum. The molecular dynamics (MD) method was applied to simulate the interaction of trifluoroacetic acid solvent with the habit faces and the corrected ...

The activity of glufosfamide (β-d-glucopyranosyl-N,N′-di-(2-chloroethyl)-phosphoric acid diamide) against pancreatic cancer was investigated in a multicentre, phase II clinical study. Chemotherapy-naı̈ve patients with advanced or metastatic disease were treated with glufosfamide (5 g/m2) using...

The activity of glufosfamide (β-d-glucosylisophosphoramide mustard) was tested in a multicentre phase II clinical trial in patients with advanced non-small cell lung cancer (NSCLC) who had received one prior line of platinum-based chemotherapy. Patients were treated with 5000 mg/m2 glufosfamide...

Glycoconjugates represent a recent trend in cancer chemotherapy that adopts the concept of selective prodrug/drug targeting of tumor cells by binding to specific transmembrane glucose transporters. Following preferential uptake of sugar conjugates into cancer cells, they are presumably subject t...

Glufosfamide is an alkylating agent consisting of iphosphoramide mustard conjugated to glucose that is currently included in clinical studies of pancreatic cancer. We studied the effects of glufosfamide, in combination with gemcitabine, on in vitro, in vivo models of pancreatic cancer. In prolif...