A variety of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline were obtained by the refluxing of 1-N-thiocarbamoyl 3,5-diphenyl-2-pyrazoline with 2,3-dichloroquinoxaline. The chemical structures of the compounds were elucidated by UV, IR, 1H NMR, and 13C NMR spectros...

An unprecedented base promoted domino approach has been developed for the synthesis of pyridin-2-yl urea derivatives via the reaction of 2-aminopyridinium salts and arylamines. The developed strategy tolerated a wide range of functional groups and afforded pyridin-2-yl ureas in moderate to good ...

The first generation of 2-bromo-3-lithioquinolines can be achieved and they are utilized for the preparation of 3-substituted 2-bromoquinolines. Thus, 2-(2,2-dibromoethenyl)phenyl isocyanides are treated with butyllithium in THF at −78 °C to generate these novel lithium compounds, which are all...

The homogeneous partial oxidation of methane is an interesting approach to obtain useful chemicals like synthesis gas, higher hydrocarbons, aldehydes or alcohols. Because of the low reactivity of methane, the homogeneous conversion needs high temperatures to proceed at reasonable reaction rates....

In this study, we synthesized dimer acid (DA) esters, having short to long alkyl chains, (DA-Cn) by the Diels–Alder reaction and subsequent esterification reaction of fatty acids that were prepared by the hydrolysis of waste vegetable oil. It was found that the DA-Cn were thermally more stable ...

This study investigates the autoignition behavior of two gasoline surrogates doped with an alkyl nitrate cetane enhancer, 2-ethyl-hexyl nitrate (2EHN) to better understand dopant interactions with the fuels, including influences of accelerating kinetic pathways and enhanced exothermicity. A prim...

The pyrolysis of n-pentane, n-hexane and n-heptane have been studied behind reflected shock waves at pressures of 1.0–2.5 atm and at temperatures of 1000–1500 K. A single-pulse shock tube (SPST) was used to measure reactant, intermediate, and product species profiles using GC samplings at diff...

In this paper, we describe the synthesis of (+)-(1R∗,2R∗)-2-[(1S∗)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid (+)-16a, a compound, that is, fluorinated at the alpha position of the carboxylic acid in the cyclopropane ring of a group II mGluRs antagonist, 1 (...

A 4-week oral study was conducted in male rats to characterize and compare the toxicity of four aliphatic ethers (butyl ether, BE; ethyl hexyl ether, EHxE; methyl heptyl ether, MHpE; and 1,6-dimethoxyhexane, DMH) which have been proposed as high-cetane diesel additives. Male Sprague-Dawley rats ...

N-decane decomposition with plasma to obtain prone detonation gaseous fuel is investigated by adopting fuel liquid film feeding mode at applied voltage of 10 kV and 15 kV, discharge frequency of 300–3000 Hz with interval 100 Hz. The result shows that the discharge parameters can regulate the co...

Enzymes play many roles in the advancement of biotechnology, discovery of new therapeutic agents and industrial processes. In this perspective, aminolysis reactions using lipase from Candida antarctica (CAL-B) were performed from ethyl (S)-mandelate and several aliphatic amines (45 °C, hexane, ...

We would like to introduce seven analogues of 2-(n-alkylamino)-1,4-napthoquinone (where n-alkyl is methyl in LH-1, ethyl in LH-2, propyl in LH-3, butyl in LH-4, pentyl in LH-5, hexyl in LH-6 and heptyl in LH-7). All the said analogues have been successfully synthesized from 1,4-naphthoquinone an...

The Michael cyanoethylation of 1-(2-aminoethyl)piperazine, 4,4′-methylenebis(cyclohexylamine) and bis(3-aminopropylamine)amine, leading to acrylonitrile free (

Dimethyl sulfoxide ruthenium(II) complexes of N-heterocyclic carbenes derived from cycloalkylamines (cycloalkyl = cyclopentyl (1a), cyclohexyl (1b), cycloheptyl (1c), and cyclooctyl (1d)) were synthesized: [RuCl2(S-dmso)2(IPent)] (2a), [RuCl2(S-dmso)2(IHex)] (2b), [RuCl2(S-dmso)2(IHept)] (2c), a...

The reaction of Pd(CH3CN)2Cl2 and NaClO4 with the ancillary ligands N,N-di(2-picolyl)cyclopentylamine (L1), N,N-di(2-picolyl)cyclohexylamine (L2) and N,N-di(2-picolyl)cycloheptylamine (L3) in ethanol yielded a new series of [(N,N′,N)-PdCl]ClO4 complexes, i.e., [PdL1]ClO4, [PdL2]ClO4 and [PdL3]C...

Anilines and cyclohexylamines are currently produced from fossil feedstocks. Phenol would be an attractive alternative feedstock that can be obtained from renewable resources. We herein clarify the influence of the amine on the course of the amination of phenol using a hydrogen borrowing strateg...

Anionic annulation of nonactivated phthalides (phthalides without a nucleofuge at C3), also referred to as Sammes annulation is a unique reaction for regiospecific synthesis of α-naphthols. It typically involves the reaction between a phthalide without a C3 nucleofuge and a α,β-unsaturated es...

Synaptic pathology occurs early in Alzheimer's disease (AD) development, and cerebrospinal fluid biomarkers for synaptic damage may be altered early in the disease process. In the present study we examined cerebrospinal fluid levels of the postsynaptic protein neurogranin in patients with m...

The N-Methyl-d-Aspartate receptor (NMDAR) antagonist kynurenic acid (KYNA) and the post-synaptic calmodulin binding protein neurogranin (Nrgn) have been implicated in neurological and neuropsychiatric conditions including Alzheimer's disease and schizophrenia. This study indicates that syst...

Neurogranin is capable of regulating protein kinase C and Ca2+/calmodulin-dependent protein kinase II. In this study, we examined the role of neurogranin in opioid tolerance. Increased phosphorylation of neurogranin was found in opioid tolerance. Opioid tolerance was absent in morphine (100 mg/k...