The coirradiated decomposition of barius and strontium azides using high intensity UV light has been studied in the temperature range 190–135°C. Activation energies have been determined for different light intensities. It is proposed that thermal and photolytic decomposition occur concurrently...

The effect of very high intensity UV light on powdered barium and strontium azides in vacuo in the temperature ranges −70° to 100°, and −80° to 90°, has been studied. The photolytic decompositions were characterized by a high percentage decomposition and sigmoid pressure vs time plots simila...

Detailed ab initio studies on the electronic structure and optical properties of crystalline strontium azide and barium azide have been performed using density functional theory (DFT) within the generalized gradient approximation (GGA). Relaxed crystal structures compare well with experimental d...

New dihydropyrimidines bearing various lipophilic pharmacophores and functionalities at position 3 were designed and synthesized. The basic framework of the new compounds was designed to maintain the main structural requirements for calcium channel blocking activity of the known dihydropyridines...

The serine hydrolase inhibitors pyrrophenone and KT195 inhibit cell death induced by A23187 and H2O2 by blocking the release of calcium from the endoplasmic reticulum and mitochondrial calcium uptake. The effect of pyrrophenone and KT195 on these processes is not due to inhibition of their known...

As a prelude to biomolecular incorporation studies, practical routes to a series of four regioisomeric azido-deoxy derivatives of inositol that mimic the natural myo-stereochemistry are described. Starting from commercially available myo-inositol, the regioselective and stereoselective introduct...

An intracellular calcium ([Ca2+]i) increase is involved in sodium azide (NaN3)-induced neurotoxicity, an in vitro model of brain ischemia. In this study the questions of possible additional sources of calcium influx, besides glutamate receptor activation, and of the time-course of NaN3 effects h...

The objective of this study was to evaluate the importance and effects of age, hair color, lactation stage and number of yak, as well as physicochemical properties and composition of yak milk on rennet-induced coagulation characteristics. Results showed that casein micelle size distribution and ...

An ultrasonically-enhanced mechanochemical method was developed to synthesize CaFe-layered double hydroxides (LDHs) with various interlayer anions (CO32−, NO3−, ClO4−, N3−, F−, Cl−, Br− and I−). The duration of pre-milling and ultrasonic irradiation and the variation of synthesis temperature in ...

Degradable elastomers with elastic properties close to those of soft tissues are necessary for tissue engineering. Most degradable elastomers developed so far are based on functional low–molecular-weight prepolymers that are combined with molecular crosslinkers to yield the elastomeric three-di...

Copper azide was successfully prepared by reaction of hollow CuO microspheres with moist HN3 gas. Porous CuO precursor with 200 nm shell was obtained by sintering PS (polystrene)/Cu core-shell structures in air. The PS/Cu composites were synthesized by electroless copper plating using PS as temp...

A variety of allyl acrylates possessing electron-withdrawing groups undergo RCM using the second generation Grubbs’ catalyst in the presence of a Lewis acid resulting in diverse butenolides in high isolated yields. This methodology provides a general route to the natural products of paraconic a...

Ceriporic acids are a class of alk(en)ylitaconic acids produced by a selective lignin-degrading fungus, Ceriporiopsis subvermispora. Their structural units have similarity with biologically important lichen acids, such as chaetomellic and protolichesterinic acids. The unique function of alkylita...

The first Mukaiyama aldol reaction on mucohalic acid (1a/b) has been achieved. Reaction of 1 with various ketene silyl acetals or silyl enol ethers in the presence of a Lewis acid provides the γ-substituted γ-butenolides in good to excellent yield.

Recent studies of diastereoselective conjugate additions of monoorganocuprates, Li[RCuI], to chiral γ-alkoxycrotonates and fumarates are disclosed. This methodology was applied to the shortest total synthesis of (−)-dihydroprotolichesterinic acid to date, but several attempts to prepare other s...

A diastereoselective synthesis of (+)-nephrosterinic acid and (+)-protolichesterinic acid, common members of the paraconic acids is described. The synthesis is based on a diastereoselective orthoester Johnson–Claisen rearrangement of a (Z)-allyl alcohol with a vicinal dioxolane moiety as key st...

(+)- and (−)-Methylenolactocins and phaseolinic acids are synthesized in four steps via asymmetric syn- and anti-aldol reactions of chiral N-succinyl-2-oxazolidinones using the same set of reagents.

A light-fluorous catch and release approach application has been designed to the separation of a mixture of three paraconic acids extracted from the Island moss (Cetraria islandica (L.) Ach.). The (+)-protolichesterinic acid was caught and released via a Michaël/retro-Michaël addition sequence w...

Stereocontrolled syntheses of the title compounds from (R)-2,3-isopropylidene glyceraldehyde, (S)-O-THP-lactaldehyde and 1,2:5,6-Di-O-isopropylidene-α-D-glucofuranose (“diacetone-D-glucose”) are described.

(−)-Roccellaric acid and variously substituted succinates are obtained through direct asymmetric carbolithiation of 2-phenylselenofumarate derivatives, followed by reaction with suitable electrophiles.