Publisher SummaryThis chapter focuses on the synthesis and applications of Pyrazol-3-ones. The chapter also highlights the reactions of the ring atoms of pyrazol-3-ones. It explores the reactivity of the ring substituents of pyrazol-3-ones. This chapter illustrates that the majority of pyrazol-3...

Serotonin (5-HT) 5-HT2C receptor agonists have shown promise as novel alcoholism pharmacotherapies, but developing selective agonists has been problematic. Female Sprague Dawley rats were given ethanol in a palatable gel vehicle during operant sessions. 5-HT2C receptor modulators (Ro60-0175, SB2...

The title compound 2, a gem vinyl sulfide ester, has been obtained diastereoselectively (de > 98%) by action of the ethyl thiophenoxyacetate carbanion on the imidazo[1,2-a]pyridinecarbaldehyde 1 in a basic medium, at low temperature. The X-ray crystal structure of 2 (C19H19N2O2S: Mr = 338.43, tr...

The title compound, gem-amidovinylsulfone 3, was synthesized stereoselectively by aldolic condensation of N,N-diethylphenylsulfonylacetamide 1 on imidazo[1,2-a]pyridine-2-carbaldehyde 2 adding Et3N at the end. The X-ray crystal structure of 3 [C20H21N3O3S: Mr=383.5, monoclinic, P21, a=8.191(4) Å...

Organic synthesis in water is a new methodology of green chemistry. AlCl3-catalyzed diazocoupling of 1-(aryl/hetaryl)-3-phenyl-1H-pyrazol-2-in-5-ones (1) in water with different aryl/hetaryldiazonium salts afforded the corresponding hetaryl-azopyrazolones (2) as colored products with high yields...

In a sequence of reactions the activated thiocyanate derivative 2 was used to synthesize new Hansa Yellow dyestuffs embodying two heterocyclic moieties. The structure of the dyes was inferred from spectral and analytical data. Spectral behaviour of the dyes indicated that they existed essentiall...

The pharmacology of lipophilic 4-arylamino- and 4-cycloalkylaminopyrid-3-ylsulfonyl(thio)ureas and their synthesis designed from torasemide are described. These compounds could lead to a method of inhibiting the astrocytic Na+ 2C1− K+ cotransporter and thus treating cerebral edema. Their lipophi...

This paper describes the results obtained in the study of the photobehaviour of heteroanalogs of stilbene bearing oxazole and pyridine rings at the opposite sides of the ethene moiety. The effect of the positional isomerism of the n-pyridyl group (n = 2, 3 and 4) on the competitive relaxation pr...

A full coverage all-inorganic cesium lead halide perovskite CsPbBr3 film is achieved by introducing a small organic molecule material, 1,3,5-tri(m-pyrid-3-yl-phenyl)benzene (TmPyPB), as a solution additive. The light-emitting diode (LED) using this CsPbBr3:TmPyPB perovskite film as light emittin...

Cu nanoparticles were prepared in successive stages: preparation of the Fe3O4 magnetic nanoparticles (Fe3O4 MNPs), coating of the Fe3O4 MNPs with tetraethyl orthosilicate (Fe3O4@SiO2), functionalization of Fe3O4@SiO2 with 3-chloropropyltrimethoxysilane (CPTMS) and 4-amino-1,2,4-triazole (AT) lig...

A total of 24 hybrid compounds containing pyridyl and 1,3-thiazole moieties were screened against HL-60 (leukemia), MCF-7 (breast adenocarcinoma), HepG2 (hepatocellular carcinoma), NCI-H292 (lung carcinoma) human tumor cell lines and non-tumor cells (PBMC, human peripheral blood mononuclear cell...

Xanthine oxidase is an important target for the treatment of hyperuricemia, gout and other related diseases. Analysis of the high-resolution structure of xanthine oxidase with febuxostat identified the existence of a subpocket formed by the residues Leu648, Asn768, Lys771, Leu1014 and Pro1076. I...

Reaction of 1-arylthiomethyl-3,5-dimethylpyrazole [ArSCH2(3,5-Me2Pz), Ar = phenyl or 2-pyridyl, Pz = pyrazol-1-yl] with Mo(CO)6 produces complexes ArSCH2(3,5-Me2Pz)Mo(CO)4, while similar reaction with W(CO)6 yields analogous complexes ArSCH2(3,5-Me2Pz)W(CO)4 and concomitant desulfurized complex ...

The photocycloaddition of 1-(4-R-phenyl)-2-(4-pyridyl)acetylenes (R = H, Br, CH3, Cl) and 1-(4-R-phenyl)-2-(2-pyridyl)acetylenes (R = H, Br, Cl) was carried out in acidic aqueous solution. The unexpected photo-dehydro-Diels–Alder reaction of these monomers was observed, and the results show tha...

A series of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines derivatives have been synthesized using sodium acetate as a catalyst. The spectral characterization and structure of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines are reported. Spectral techniques employe...

2-Phenyl-1,3-di(4-pyridyl)naphthvalene 3a was synthesized by the photoinduced reversible valence isomerization of 2-phenyl-1,3-di(4-pyridyl)naphthalene 2a. Then, 3a was converted into 3-phenyl-1,2-di(4-pyridyl)naphthalene 4a and 2a simultaneously. The t1/2 of 3a in DMSO-d6 at 90 °C was 2 h, whi...

A new chiral binuclear copper(II) complex of (S)-2-(diphenylmethanol)-l-(2-pyridylmethyl)pyrrolidine (S-dmpmpH) was prepared by direct electrochemical oxidation of Cu electrode in acetonitrile solutions. The final product, Cu2(S-dmpmp)2Cl(μ-OH) was crystallized and characterized by microanalysi...

A series of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives were designed as potential anticancer agents. These compounds were conveniently prepared by using Pd/C–Cu mediated Sonogashira type coupling as a key step. Many of these compounds were found to ...

Cirsium yildizianum stalks were liquefied in organic solvents under supercritical conditions with and without catalyst in a cylindrical reactor at temperatures of 260, 280 and 300 °C. The effects of liquefaction temperature, catalyst type and solvent on product yields were investigated. The liq...

The methyl Z-2-acetamido(or benzamido)-3-aryl-2-butenoates (Z-9a-e,Z-10a-e) were obtained by two alternative procedures: stereo-specific opening of Z-2-methyl(or phenyl)-4-|α -arylethylidene|-5(4H)-oxazolones (Z-7a-e,Z-8a-e) and stereospecific homologation of methyl Z-2-acetamido (or benzamido)...