Publisher SummaryThis chapter provides a compilation of health, chemical compatibility, and fire hazard data for 450 chemicals which are manufactured within the industry sector. The data are compiled from reviewing product Material Safety Data Sheets. This chapter is an illustration of tables, w...

Two tripeptides of the type Boc-Pro-ΔZX-Gly-NHEt (where X = Leu, Phe) have been synthesized and their solution conformations investigated by 270 MHz 1H n.m.r. and i.r. spectroscopy. These conformational studies indicated that ΔZLeu, similar to ΔZPhe, has a strong tendency to stabilize folded ...

-Reaction of 6a–f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a–f in excellent yield. The newly synthesized heterocycles were characterized by IR, 1H NMR, and mass spectral data. Compounds 7a–f was screened for their anti-inflammatory activity and were compared with st...

The effects of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 (a cAMP-dependent protein kinase and protein kinase C inhibitor), n-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 (a cAMP- and cGMP-dependent protein kinase inhibitor) and indomethacin (IND, a cyclooxygenase inhibitor) on ...

Targeting CDK4/6 has been identified as an effective therapeutics for treatment of cancer. We herein reported the discovery of a series of 6-(2-(methylamino)ethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine derivatives as CDK4/6 inhibitors against cancer. Compound 3c, which displayed high poten...

New urea-coordinated dinickel(II) complexes with binucleating ligands—HL1, which contains dimethylaminoethyl arms, and its analogs HL2, which features bis(methoxyethyl) arms, and HL3, which contains one dimethylaminoethyl arm and one bis(methoxyethyl) arm—all of which contain a 2-hydroxytrimet...

We report the synthesis, binding properties and intrinsic activity at MT1 and MT2 melatonin receptors of new dimeric melatonin receptor ligands in which two units of the monomeric agonist N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide (1) are linked together through different anchor points. ...

The Schiff base compound (Z)-4-methyl-N-[2-((2-oxonaphthalen-1(2H)-ylidene)methylamino)ethyl]-benzenesulfonamide has been synthesized and characterized by IR, UV–Vis and single-crystal X-ray diffraction. Molecules of the title compound exist as NH tautomeric form in solid state. Molecular geome...

A single-center, prospective double-blind randomized trial was conducted to compare the efficacy and safety of the calcium channel blocker nisoldipine in a sustained release coat-core formulation (CC), titrated from 10 mg to 40 mg daily, with the angiotensin converting enzyme inhibitor enalapril...

We have studied the O2/O2− redox couple on the HMDE in DMSO aprotic media, obtaining optimal conditions of both oxygen concentration and scan rate in order to avoid oscillatory phenomena. By choosing the oxygen concentration and scan rate appropriately we obtained well-resolved reversible and re...

Nisoldipine, a second-generation dihydropyridine calcium antagonist, is a racemate compound used in the treatment of hypertension and coronary heart disease. This study presents an enantioselective HPLC-GC–MS method for the analysis of nisoldipine in human plasma and establishes confidence limi...

A sensitive and specific liquid chromatography–tandem mass spectrometric (LC–MS–MS) method has been developed to determine m-nisoldipine in rat plasma. Sample was pretreated by a single-step protein precipitation with acetonitrile, in contrast to the liquid–liquid procedure frequently used f...

The excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) plays a critical role in the development of pulmonary arterial hypertension. Recent studies indicate that Ca2+ and reactive oxygen species are critically involved in the process of smooth muscle cell proliferation stimu...

A simple, sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the simultaneous determination of m-nisoldipine and its three metabolites in rat plasma has been developed using nitrendipine as an internal standard (IS). Following liquid–liquid extraction...

Two polymorphic crystal forms of m-nisoldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester) were characterized by X-ray powder diffraction and IR-spectroscopy. The solubility of the two polymorphs in water at 25, 31, 37, 42, and 49 °C wa...

This is a report about the investigation of the metabolic fate of m-nisoldipine in human liver microsomes and the recombinant cytochrome P450 enzymes by using LC–MS/MS. A sensitive and reliable LC–MS/MS method was developed to obtain a rapid and complete characterization of new metabolites and...

A rapid, sensitive and selective liquid chromatography–tandem mass spectrometric (LC/MS/MS) method was developed and validated for the separation and determination of m-nisoldipine enantiomers in beagle dog plasma. Samples were pretreated by a single-step protein precipitation with acetonitrile...

SummaryThe pressure-temperature phase diagram of the dimorphism of racemic m-nisoldipine is constructed using temperatures and enthalpies of fusion of forms A and B. At ordinary pressure, the transition from form B to form A is found to occur around 192 K, which indicates that these polymorphs a...

Poly(2-bromoethyl methacrylate) degrades thermally in three well defined stages to give monomer as the main product together with small proportions of vinyl bromide and carbon dioxide. These products are accounted for in terms of competing reactions of depolymerization and ester decomposition. A...

The crystal structures of the ionic compounds [(CH3)3NCH2CH2Br]Br (1) and [(CH3)3NCH2CH2SC(NH2)2]Br2 (2) as well as the reaction product of 1 with thiourea, [(CH3)3NCH2CH2SC(NH2)2]Br2·4(NH2)2CS (2·4 thiourea) have been determined by single-crystal X-ray diffraction, 273 K for 1 and 2·4 thiour...