A novel biocatalytic method for the enantioselective synthesis of (R)-bromo-3-[4-(2-methoxy-ethyl) phenoxy]-2-propanol [(R)-BMEPP], a precursor for the synthesis of (S)-metoprolol, an anti hypertensive drug is described. We have developed kinetic resolution of rac-BMEPP by transesterification us...

Amyl nitrite (CAS: 110-46-3) is a volatile liquid supplied in ampoules that had been historically used as a component in cyanide antidote kits and recreationally as ‘poppers.’ When amyl nitrite is used in this manner it is inhaled or ‘huffed.’ Its toxicity is primarily through its oxidative ...

Inhalable nitrites consist primarily of the volatile alkyl nitrites, amyl nitrite (Chemical s Service Registry Number (CAS) 463-04-07), butyl nitrite (CAS 544-16-1), and isobutyl nitrite (CAS 542-56-3). While amyl nitrite has been used clinically in humans since the late 1800s; other members of ...

Synthesis of silver nanoparticles has the potential to be utilized as a good, eco-friendly approach for the control of mosquito population. In the present study, synthesis of silver nanoparticles using isoamyl acetate isolated from Annona squamosa against mosquito larvae was carried out. The syn...

A new method for the preparation of high concentrations of peroxynitrite (up to 1M) is described. The synthesis uses a two-phase system and involves a displacement reaction by the hydroperoxide anion (in the aqueous phase) on isoamyl nitrite (in the organic phase). The product peroxynitrite rema...

Ketones undergo α-oximation by NOCl formed in situ from Me3SiCl and isoamyl nitrite, either in solution or under solvent-free conditions, to produce 1,2-dione monooximes in excellent yields. The oximation is regiospecific in appropriate cases.

Although alkyl nitrites are used as recreational drugs, there is only little research data regarding their effects on the central nervous system including their neurotoxicity. This study investigated the neurotoxicity of three representative alkyl nitrites (isobutyl nitrite, isoamyl nitrite, and...

A method for the synthesis of peroxynitrite is described. It involves nitrosation of H2O2 at pH ⩾ 12.5 by isoamyl or butyl nitrite in mixed solvents of isopropyl alcohol (IPA) and water at 25 ± 1 °C. Maximum yields of peroxynitrite are obtained after 15 min of incubation at IPA concentrations ...

The abuse of alkyl nitrites is common among adolescents and young adults worldwide. However, the information regarding the effects of alkyl nitrites on the central nervous system and the associated psychological abuse potential is scarce. The abuse potential of 3 representative alkyl nitrites –...

Oxidation of cycloalkanes with molecular oxygen using isoamyl nitrite was examined under mild conditions. Cycloalkanes were easily oxidized with molecular oxygen to give the corresponding cycloalcohols, cycloalkanones and dicarboxylic acids at 120 °C or lower temperatures. The oxidation of the ...

Densities, viscosities and speeds of sound of the binary systems of isopentyl acetate with chlorobenzene, bromobenzene and fluorobenzene have been measured as a function of composition at 303.15 and 313.15 K. Other mixing properties of interest such as excess volumes VE, viscosity deviations ∆η...

Transition metal ion (Cd2+, Co2+, Cu2+, Mn2+, Ni2+, Zn2+) transfer from water to methyl n-amyl ketone (2-heptanone) and methyl n-hexyl ketone (2-octanone) facilitated by nitrogen-containing ligands has been investigated by a.c. and d.c. voltammetry. For Cd2+, Cu2+ and Zn2+ in the presence of ter...

This article describes a newly developed method of gas chromatography (GC) for the rate study of the reduction of organic compounds by samarium iodide. Solvent extraction was used to reduce the interference of GC analysis by inorganic species. Adequate recoveries ranged from 88.3 to 94.5 % and g...

The electron impact ionisation of 2-heptanone between 13 and 78 eV is studied using mass spectrometry. CH3C(O)CH2CH2CH2CH2CH3+ and fragment ions are produced with a total cross-section of 5 × 10−16 cm2 towards 50 eV. Two ions, identified as CH3CO+ (43 amu) and CH3C(OH)CH2+ (58 amu), contribute ...

The concentration of 2-heptanone, derived from decarboxylation of β-ketoacids naturally present in milk, has been shown to be affected by the severity of heat-treatment applied to cows’ milk. In this paper, the influence of microfiltration (MF) coupled with mild pasteurisation, on the developm...

By the gravimetric method, the solubility of sorbic acid in eight solvents including ethanol, 2-propanol, methanol, 1-butanol, ethyl acetate, methyl tert-butyl ether, acetone and acetonitrile was determined over a temperature range from 285.15 to K at atmospheric pressure. For the temperature ra...

This work reports a temperature-dependent vibrational spectroscopic study of the sorbic acid (C6H8O2), as well as the mode assignment at ambient conditions, based on the density functional theory. Temperature-dependent vibrational properties have been performed in polycrystalline sorbic acid thr...

Preservatives in processed meat raise significant concerns associated with bowel cancer and diabetes, and implicate various public health issues. This introduces the need for safer preservatives to uphold public health standards. However, developing safer alternatives to these preservatives pose...

The preservatives benzoic acid and sorbic acid are generally quantified with separation techniques, such as HPLC or GC. Here we describe a new method for determining these compounds in processed food samples based on a narrowness of the UV–visible spectral band width with derivative processing....

The use of organic acids as preservatives in foods is an alternative for restricting the development of moulds in food and subsequently reducing the possibility of mycotoxin contamination. The objective of this study was to investigate the influence of acetic and sorbic acids on the growth of sp...