In this study, potential immunological and hematological effects of different concentrations (0, 1, 10, and 50 μg L-l) of waterborne zinc pyrithione (ZnPT) were studied in the blood of the olive flounder Paralichthys olivaceus over 30 days. Reduced alternative complement activity (ACH50) and ly...
Zinc pyrithione (ZPT), a zinc coordination complex, is used as an antimicrobial agent. This study investigated the molecular mechanisms underlying ZPT-induced spermatozoa immobilization by examining plasma membrane integrity, mitochondrial dysfunction, and the cAMP/PKA signaling pathway response...
We demonstrated a simple, fast, reliable quantitative spectrophotometry based approach to estimate ZPT in a suspension as an alternative to conventional HPLC based technique. By appropriately dosing known amount of copper ions, we could displace the “relatively labile” zinc ion from the crysta...
Metal complexation with 2-hydroxy-6-methylpyridine-3-carboxylic acid has been studied. The ligand finds use in detection and determination of iron (III). The order of stability constants of the bivalent transition metal complexes is Cu > Zn > Fe > Ni > Co > Mn. b]¦de¦Die Komplexbildung von Metal...
Fourier transform IR and Raman spectra, XRD studies and DFT quantum chemical calculations have been used to characterize the structural and vibrational properties of 2-hydroxy-5-methylpyridine-3-carboxylic acid. In the unit-cell of this compound two molecules related by the inversion center inte...
The synthesis and characterization of (p-cymene)RuII, Cp*RhIII and Cp*IrIII complexes with N-alkyl and N-aryl substituted 3-hydroxy-2-methyl-4-pyridone ligands is reported. All compounds display an unusually high solubility in water. With the chiral ligand N-(o-C6H4CO2Me)-3-hydroxy-2-methyl-4-py...
Mimosine and 3-hydroxy-4(1 H)-pyridone were extensively degraded in solutions at pH > 9.5 when held at temperatures of 80–120° for 1–2 hr. Mimosine was also degraded at pH 1.
Absorption spectra of ten 5-(4-substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones have been recorded in fifteen solvents in the range 200–600 nm. The substituents at the phenyl nucleus are as follows: OH, OCH3, CH3, C2H5, H, Cl, Br, I, COOH and NO2. The effects of substituents on the a...
The properties and the diazotisation process of 1-ethyl-5-cyano-6-hydroxy-4-methyl-5-amino-2-pyridone were described. The conditions of the coupling reaction were also discussed and a series of new azo dyes using 1-ethyl-5-cyano-6-hydroxy-4-methyl-3-amino-2-pyridone as diazo components were synt...
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to be the key to CEN inhibition. In particular, t...
A range of close analogues of deferiprone have been synthesised. The group includes mono-, di- and tri-methyl-3-hydroxy-4(1H)-pyridones. These compounds were found to possess similar pFe3+ values to that of deferiprone, with the exception of the 2.5-dimethylated derivatives. Surprisingly the NH-...
An efficient in-situ reduction and cyclization reaction was reported from the aromatic aldehydes, 6-nitro-1H-indazole (5-nitrobenzimidazole), and 2,2-dimethyl-1,3-dioxane-4,6-dione (1,3-cyclohexanedione or dimedone) to synthesize 9-aryl-1,6,8,9-tetrahydro-7H-pyrazolo[3,4-f]quinolin-7-one, 11-ary...
(S)-Perillyl alcohol was converted to (R)-cryptone (91.5–93% ee) in six steps, which was then treated with methyllithium to give (1S,4R)-4-isopropyl-1-methyl-2-cyclohexen-1-ol, the aggregation pheromone of the ambrosia beetle Platypus quercivorus. The racemic pheromone was also prepared by meth...
Both the enantiomers of 1-methyl-2-cyclohexen-1-ol, an aggregation pheromone of the female Douglas-fir beetle, were synthesized from the enantiomers of seudenol (3-methyl-2-cyclohexen-1-ol). The enantiomers were less active than the racemate of 1-methyl-2-cyclohexen- 1-ol as an aggregation phero...
The 1,4-addition of the enolate generated from α-methylated acetoacetate incorporated at C-4 of methyl 6-deoxy-2,3-di-O-(tert-butyldimethylsilyl)-α-d-glucopyranoside to methyl vinyl ketone, followed by aldol condensation of the resulting 1,4-addition product under two base-mediated conditions,...
A concise diastereoselective and enantiopure route to the (1S,4R)- and (1S, 4S)-isomers of 4-isopropyl-1-methyl-2-cyclohexen-1-ol via a palladium-catalysed deoxygenation of the enol triflate derived from limonene glycol.
1-Methyl-2-cyclohexen-1-ol has been prepared by a three step synthesis from 1-methylcyclohexene, in greater than 94% e.e., via a ‘merged substitution–elimination reaction’ between NaSePh and 2-methyl-2-hydroxycyclohexyl p-toluenesulphonate.
A toxicologic and dermatologic review of 3-methyl-4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-3-buten-2-one when used as a fragrance ingredient is presented.
In this contribution, we have developed an efficient and recyclable porous organic polymer (POP) supported Pd nanoparticle catalyst (Pd°-PyPPh2@POP) for dehydrogenation of 3-methyl-2-cyclohexen-1-one. This heterogeneous catalytic system represents a totally clean process without using any extra...
Hydrogen bonding is a weak chemical interaction widely existed in the variety of organic and biological molecules. As an important structural motif of pyrimidine bases, the solvent effect of the hydrogen bonding of 2-cyclohexen-1-one (CHO) and 3-methyl- 2-cyclohexen-1-one (3MCHO) and its effect ...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View