Six coordination complexes were successfully synthesis through self-assembly of multiple components. Here upon ligands and different carboxylates variation, we reported on the assembly of six new organic–inorganic hybrid complexes with different silver nuclei. Four novel complexes based pza lig...
The emergence of multidrug-resistant bacterial strains has heightened the need for new antimicrobial agents based on novel chemical scaffolds that are able to circumvent current modes of resistance. We recently developed a whole-animal drug-screening methodology in pursuit of this goal and now r...
New supramolecular solids whose topologies depend on the counteranion, [Ag(MPCI)(CF3CO2)] (1) and [Ag2(MPCI)2(CH3OH)(CF3SO3)]CF3SO3 (2), have been prepared by the self-assembly of AgX (X=CF3CO2-andCF3SO3-) with pyrazinecarbonitrile (MPCI = methyl pyrazine-2-carboximidate). Both compounds are com...
The ligand 1,6-bis(diphenylphosphino)hexane undergoes a dehydrogenation reaction with M2X2(C8H12)2, C8H12 = cis cis cycloocta-1,5-diene to form MX(BDPH), M Rh and X Cl or Br, or M Ir and X C1, and BDPH 1,6-bis(diphenylphosphino)-trans-hex-3-ene. In the presence of carbon monoxide ...
A thermochemical study of 1,6-bis(diphenylphosphino)hexane(BDPH) has been performed using adiabatic calorimetry, differential scanning calorimetry (DSC) and thermogravimetric analysis (TG). The low-temperature heat capacity of BDPH was determined precisely with a small-sample automated adiabatic...
Background and aimLignosus rhinocerus (LR) is an edible mushroom with a variety of medicinal properties such as neurostimulation, immunomodulation, anti-inflammation, anti-oxidation, anti-proliferation, anti-diabetes and especially antiviral activity. Human immunodeficiency virus type-1 (HIV-1) ...
SummaryDiastereomeric forms of l-(pyrrolidin-1-ylmethyl)-2-(N-methyl)-4-[(3,4-dichloro)phenyl]-1,2,3,4-tetrahydroisoquinol in-3(2H)-ones 3a and its chloro analog 3c were synthesized. Compounds 3a,c are related to the κ-selective opiate ICI 199441 1 by linking the benzylic CH2 to the ortho posit...
The symmetrical octafluoro stilbene trans-1,2-bis(2,3,5,6-tetrafluorophenyl)ethylene (1) undergoes a stereoselective and quantitative [2 + 2] photodimerization in the solid state. The olefin self-assembles via C-H⋯F and face-to-face interactions of the fluorinated phenyl rings into a geometry fo...
The reaction of [PtX2(L)] (X = Cl, Br, I; L = NH2CH2CH2NY2; Y = Et, Me) with thallium(I) carbonate and a polyfluorobenzene (RF) in pyridine (py) yields the platinum(II) complexes, [Pt{N(R)CH2CH2NY2}X(py)] (R = C6F5, 4-HC6F4, 4-BrC6F4, or 4-IC6F4, Y = Et (1), Me (2), X = Cl, Br or I) in an improv...
New potent histamine H3-receptor antagonists containing an ether group were synthesized from 3-(1H-imidazole-4-yl)propanol and various substituted diphenylmethyl chlorides. Some of the designed ethers showed high activity at histamine H3-receptors under in vitro as well as under in vivo conditio...
In this letter, we describe a series of 4-substituted piperidine and piperazine compounds based on tetrahydroquinoline 1, a compound that shows balanced, low nanomolar binding affinity for the mu opioid receptor (MOR) and the delta opioid receptor (DOR). We have shown that by changing the length...
The photophysical behaviour of two carbostyrils used as layer dyes has been investigated. From a study of the solvent polarity dependence of the fluorescence properties we have shown that twisting of the amino or dimethylamino group does not affect the photophysical behaviour of carbostyrils. Th...
Absorption and fluorescence spectra as well as quantum yields of a series of differently substituted carbostyrils (quinolin-2(1H)-ones) are reported. Especially for compounds containing donor substituents in position 6, substantial bathochromic shifts (comparable to analogous coumarins) of both ...
We have used computational chemistry methods to aid the rational design of long-wavelength absorbing and emitting organic materials. For this purpose, the vertical electronic transition energies of 3,4-dicyano carbostyrils (quinolone-2(1H)-ones) substituted by electron-donating substituents (met...
Direct current and differential pulse polarography, linear sweep cyclic voltammetry, UV and fluorescence spectroscopy techniques were employed to study the reduction of 2-hydroxy-3-phenyl-6-methylpyrazine (HPMP), a degradation product of β-lactam antibiotics. The reactions associated with the r...
N-(2-Chloro-phenyl)-2-halo-benzamides (halo=I/Br/Cl) as substrates were used for the one-pot synthesis of 2-arylbenzoxazole derivatives via copper-catalyzed intermolecular C–N/intramolecular C–O couplings with primary amines. This aryl amination offers clean reaction conditions and easy work-u...
A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a 4-phenylthiazol-2-yl group showed highly potent DPP-4 inhibitory activity. Among various derivatives, (3R)-3-amino-N-(4-(4-phenylthiazol-2-yl)-te...
The title compound 4-[N, N-di(4-tolyl)amino] benzaldehyde-2-chloro benzoylhydrazone (C28H24ClN3O, Mr = 453.96) was synthesized by the reaction of 4-[N, N-di(4-tolyl)amino] benzaldehyde with 2-chlorobenzohydrazide, and its structure was characterized by IR, 1H NMR, 13H NMR, high-resolution mass s...
An expanded set of pyridazine-containing benzene sulfonamides was investigated for inhibition of four human carbonic anhydrase isoforms, which revealed a pronounced inhibition trend toward hCA IX, a cancer-related, membrane-bound isoform of the enzyme. Comparison of antiproliferative effects of ...
As a part of our quest for the synthesis of new bioactive heterocyclic compounds, in our present work we have synthesized a series of 4-(4-(arylamino)-6-(piperidin-1-yl)-1,3,5-triazine-2-ylamino)-N-(pyrimidin-2-yl)benzenesulfonamide (3a–o) derivatives. The newly synthesized compounds were scree...
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