1-Haloethynyl-2-methylcyclopentanols treated with iodine and HTIB ring expand stereoselectively depending on the relative position of the methyl and the hydroxyl groups. The products are 2-(dihalomethylidene)-3-methylcyclohexanones if the methyls are cis to the hydroxyl groups or 2-(dihalomethyl...
A convenient synthetic route to 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues as 5-LO inhibitors is described. This methodology enabled rapid development of structure–activity relationships (SARs) leading to improvement of pharmacological properties....
Cannabinoid CB1 receptor agonists exhibit potent analgesic effects in rodents and humans, but their clinical utility as analgesic drugs is often limited by centrally mediated side effects. We report herein the preparation of N-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6...
A cascade, composed of (i) oxovanadium(V)-catalyzed oxidation of bromide by tert-butyl hydroperoxide and (ii) stereoselective 6-endo-bromocyclization, affords 3-bromo-2-aryl-2,6,6-trimethyltetrahydropyrans from styrene-type tertiary alkenols in synthetically useful yields. (E)-Alkenols add the b...
Publisher SummaryThe twenty-five carbon backbone of zincophorin contains interesting structural elements, such as a propionic acid unit branched at C2 with a trisubstituted tetrahydropyran (C3–C7), alternate methyl and hydroxyl groups (C8–C13 and C18–C 19), one disubstituted double bond (C16–...
A new series of novel opioid ligands have been designed and synthesized based on the 4-anilidopiperidine scaffold containing a 5-substituted tetrahydronaphthalen-2yl)methyl group with different N-phenyl-N-(piperidin-4-yl)propionamide derivatives to study the biological effects of these substitue...
Constant current electrolysis of 2-(2-propynyloxy)bromobenzenes in DMF using an undivided cell equipped with a Pt cathode and an Mg anode in the presence of carbon dioxide and an electron transfer mediator, methyl 4-tert-butylbenzoate, resulted in aryl radical cyclization with a carbon–carbon t...
Single crystals of L-methionine L-methioninium perchlorate monohydrate (LMMPC) have been achieved from the aqueous solution by slow evaporation technique. The structure of LMMPC has been determined by single crystal X-ray diffraction method. Fourier transform infrared and Raman spectroscopic stu...
Perchlorate (ClO4−) had caused great impacts to human health via inhibiting the uptake of iodide by the thyroid gland and its removal was strongly affected by co-existing anions in aqueous solution. The adsorptive features of perchlorate, co-existing anions and their removal mechanisms on two di...
Two thio-urea based bifunctional probes (H2L1-S and H2L2-S) have been designed and fabricated for the colorimetric and fluorometric detection of mercury(II) and acetate ions respectively in DMSO media. Both the H2L1-S and H2L2-S were fully characterized by various spectroscopic techniques and th...
The present study investigates the electro-oxidation (EO) treatment of urea containing wastewater using mixed metal oxide (MMO) anodes. Box-Behnken design (BBD) was employed to analyze the effects of various operational process parameters like current density (j), NaCl dose (n), treatment time (...
Fresh water is a fundamental source for humans, hence the recent shrinkage in freshwater and increase in water pollution are imperative problems that vigorously affect the people and the environment worldwide. The breakneck industrialization contributes to the procreation of substantial abundanc...
Urea represents a common form of organic nitrogen (N) which is added to agricultural soils in large quantities in both cropping (e.g. fertiliser) and livestock (e.g. urine) systems. In addition, there is a small, dynamic ambient pool of urea in soil associated with metabolic functioning in the m...
In this work, the oxazine 170 perchlorate (O17)-ethyl cellulose (EC) membrane was successfully applied in the fabrication of a urea-sensing membrane. The urea-sensing membrane was a double layer consisting of the O17-EC membrane and a layer of the enzyme urease entrapped into EC matrix. The sens...
Denaturant effect of urea has been interpreted by two mechanisms, the direct interaction of the additive with biomolecules or lyophilic colloidal aggregates or the indirect mechanism via rupture of the water 3D structure. In contrast we focused that urea produces a higher polarity of aqueous mix...
Cobalt substituted nickel spinel ferrites were synthesized in the form of Ni1-xCoxFe2O4(x=0-1,Δx=0.15) via Pechini’s sol–gel citrate method with final sintering at 1000 °C for 6 h. Structural purity of the prepared ferrites is examined by using X-ray diffraction (XRD), Raman spectroscopy, sc...
In this study, the electrodeposition of the ternary Co-Mo-Re alloy from a complex citrate electrolyte has been investigated. The effect of solution pH, temperature and current density on the chemical composition, current efficiency and morphology of the obtained coatings is shown. It has been fo...
The application of potassium promoted Co-ZnO-Al2O3 catalysts prepared by co-precipitation and citrate methods in the steam reforming of ethanol and methanol has been studied. Experimental results of catalytic activity and selectivity of catalysts are reported. The influence of preparation method...
Zn–Co alloy coatings deposited by pulsed current (PC) typically exhibit higher adhesion, lower porosity and smaller grain size than those deposited by direct current (DC). All of these features contribute to the improved anticorrosive performance observed in PC Zn–Co coatings. Additionally, an...
Different cobalt phases are deposited on graphite discs from CoSO4 baths in absence and presence of equimolar concentration of citrate ions, Co/G and Co(cit)/G, respectively. The prepared electrodes are subjected to different electrochemical studies. Benchmark recommends the use of the overpoten...
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