Ioxynil, a phenolic herbicide, is known to exert thyroid hormone (TH) disrupting activity by interfering with TH-binding to plasma proteins and a step of the cellular TH-signaling pathway in restricted animal species. However, comparative studies are still lacking on the TH disruption. We invest...
The reduction mechanism of ioxynil (3,5-diiodo-4-hydroxy-benzonitrile) was studied in dimethylsulfoxide using the electrochemical methods (tast polarography, cyclic voltammetry and controlled potential electrolysis) combined with GC/MS identification of products. The reduction is accompanied by ...
Gap junctions are intercellular plasma membrane domains containing channels that mediate transport of ions, metabolites and small signaling molecules between adjacent cells. Gap junctions play important roles in a variety of cellular processes, including regulation of cell growth and differentia...
BackgroundEndocrine disruption is one of the consequences of industrialization and chemicals released into the environment have a profound impact on organisms. Waterborne micromolar concentrations of ioxynil (IOX) and diethylstilbestrol (DES) in fish affect the development of the heart, vasculat...
This paper describes the biodegradation of the ioxynil octanoate herbicide by indigenous microorganisms isolated from herbicide impacted soil-enrichment cultures. Eleven positive hits out of twenty-nine microorganisms screened for nitrile hydratase, nitrilase and amidase activity were further ev...
Herein, microwave-assisted direct coupling of Graphene Nanoplatelets (GNP) with polymers including hydroxyl (OH) groups such as poly ethylene glycol (PEG) and bio-molecules like 4-phenylazophenol (Azo) are investigated. Among different water-soluble polymers, PEG has received unique consideratio...
The reaction of 3,4-di-tert-butylthiophene (2) with N-[(p-tolylsulfonyl)imino]-phenyliodinane (TsN=IPh) in the presence of Cu(MeCN)4PF6 in MeCN at room temperature provided 3,4-di-tert-butyl-1-[(p-tolylsulfonyl)imino]-1,1-dihydrothiophene (3), 3,4-di-tert-butyl-1,1-bis[(p-tolylsulfonyl)imino]-1,...
Penning ionization electron spectroscopy and CNDO/S calculations have been successfully applied to the analyses of the UV photoelectron spectra of 2- and 2,5-bistrimethylsilylthiophene and 2-t-butylthiophene. The relative intensities of the π type bands are greatly enhanced in the Penning spect...
When |8|(2,5)thiophenophane (4) is treated with an excess of t-BuCl/SnCl4 in CS2 at room temperature, a deepseated rearrangement occurs, t-butyl groups are introduced into the 2- and 5-position of the thiophene nucleus with a concomitant migration of the octamethylene bridge to the 3- and 4-posi...
3,4-Di-t-butylthiophene (1) was surprisingly easily synthesized from readily accessible bis(2-t-butyl-2-oxoethyl) sulfide (2). Reactions of 1 with a variety of electrophiles were examined.
3,4-Di-t-butylfuran (1), pyrrole (2), and selenophene (4) were first synthesized using 3,4-di-t-butylthiophene (3) as the starting material and these overcrowded five-membered hetarenes including 3 were characterized by NMR and MMP2 calculations.
Treatment of 3,4-di-t-butylthiophene 1-oxide with (CF3CO)2O or (CF3SO2)2O, followed by reaction with RSO2NH2, ROC(O)NH2, or RCONH2 furnished a series of 1-imino derivatives of 3,4-di-t-butylthiophene, which carry an electron-withdrawing substituent on the imino nitrogen atom. Treatment of an i...
The ratio of isomeric σ-complexes formed, from thiophene, t-butyl chloride and AlCl3 was found to be changed while keeping at room temperature within 1–2 days. This allows to obtain after deprotonation 2-t-butylthiophene containing only 3% of 3-isomer. Transformations of σ-complexes formed by...
Catalytic activity of Mn(III) and Fe(III) complexes of meso-tetra(n-propyl)porphyrin, MnT(n-Pr)P(X) and FeT(n-Pr)P(X) (X = Cl, SCN, OAc) in oxidation of olefins with tetra-n-butylammonium periodate at room temperature has been studied. The influence of different parameters including the molar ra...
Fluorescence excitation spectra of cis-stilbene in n-hexane monitored at 350 nm and 404 nm, are resolved into cis-stilbene and trans-stilbene contributions using principal component analysis with self-modeling. The results confirm that both trans and cis fluorescence originating from excitation ...
SummaryStereochemistry in the hydrolysis of isomeric cis- and trans-olefin oxides by hepatic microsomal epoxide hydrolase has been described. cis- and trans-Stilbene oxides used as model substrates for this purpose were hydrolyzed with a strict stereos electivity by rabbit liver microsomes to d-...
A series of new stilbenes 4a–e, 5 were synthesized through a novel one-pot Perkin-like reaction between 6,7-dimethoxyhomophthalic anhydride and aromatic aldehydes, followed by treatment with BBr3. This synthesis is straightforward and allows polyhydroxylated cis-stilbenes gathering two well-kno...
Vanadium-containing faujasite zeolite catalysts were synthesized by a facile ion-exchange method in such a way that the collapse of zeolite long-range order structure did not occur. The vanadium loadings and the degrees of ion exchange can be controlled by changing the concentrations of vanadium...
To investigate the relationship between glutathione (GSH) depletion and metallothionein (MT) synthesis, the effects of substrates and an inhibitor of GSH S-transferases on concentrations of hepatic GSH, zinc (Zn) and MT were studied in rats. Trans-stilbene oxide (TSO) is an inducer of drug metab...
cis-Stilbenes were synthesized stereospecifically in high yields from the cuprous oxide-catalyzed decarboxylation of α-aryl-trans-cinnamic acids that were prepared from the Perkin condensation of benzaldehydes and phenylacetic acids.
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