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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Dimebolin

Cas:3613-73-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dimebone

Cas:3613-73-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

dimebolin

Cas:3613-73-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Dimebolin

Cas:3613-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

dimebolin CAS:3613-73-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

dimebolin CAS:3613-73-8

Cas:3613-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Dimebolin

Cas:3613-73-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Latrepirdine 3613-73-8

Cas:3613-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Dimebolin

Cas:3613-73-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

Dimebolin

Cas:3613-73-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

Dimebolin

Cas:3613-73-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

dimebolin

Cas:3613-73-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Other

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,5-tetra...

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

DiMebon (latrepirdine)

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Dimebolin Synonyms 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-1H-pyrido[4,3-b]indole Molecular Structure

Dimebolin 3613-73-8

Cas:3613-73-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white crystals powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

DimebolinAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

3613-73-8

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Dimebolin

Cas:3613-73-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Dimebolin

Cas:3613-73-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

dimebolin Basic information Product Name: dimebolin Synonym

dimebolin

Cas:3613-73-8

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

Dimebolin

Cas:3613-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Sunsure Chemical Technology Co., Ltd

Nanjing Sunsure Chemical Technology Co., Ltd., established in 2009, has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Sunsure covers whole

Dimebolin 3613-73-8 supplier

Cas:3613-73-8

Min.Order:1 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-methyl-5-vinylpyridine
140-76-1

2-methyl-5-vinylpyridine

2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
19686-05-6

2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
With potassium phosphate In ISOPROPYLAMIDE at 100℃; for 24h; Inert atmosphere;80%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 100℃;55%
With potassium hydroxide In diethylene glycol dimethyl ether at 120℃; for 42h; Product distribution / selectivity;52%
With sodium ethanolate; sodium In dimethyl sulfoxide at 90 - 95℃;
With potassium phosphate In ISOPROPYLAMIDE at 130℃;
tert-butyl 8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate
1227258-81-2

tert-butyl 8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Reflux;70%
1-Methyl-4-piperidone
1445-73-4

1-Methyl-4-piperidone

2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine
21241-08-7

2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
With acetic acid In water at 20℃; for 4h; Inert atmosphere; Reflux;
With hydrogenchloride In isopropyl alcohol for 0.25h;
N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine
1229621-60-6

N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 100℃; for 0.5h;
Stage #1: N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine With hydrogenchloride; water In ethanol at 80℃; for 1.5h;
Stage #2: With sodium hydroxide In ethanol; water pH=14;
Stage #1: N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine With hydrogenchloride In ethanol at 80℃; for 1.5h; Reflux;
Stage #2: With sodium hydroxide In ethanol; water pH=14;
Latrepirdine dihydrochloride

Latrepirdine dihydrochloride

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
With sodium hydroxide In 2-methyltetrahydrofuran; water for 1.25h;
2-methyl-5-vinylpyridine
140-76-1

2-methyl-5-vinylpyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: phosphorus tribromide / diethyl ether / 3 h / 0 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C
2: hydrogenchloride / isopropyl alcohol / 0.25 h
View Scheme
2-(6-methylpyridin-3-yl) ethan-1-ol
100189-17-1

2-(6-methylpyridin-3-yl) ethan-1-ol

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus tribromide / diethyl ether / 3 h / 0 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
3: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Br(1-)*C21H22N3(1+)

Br(1-)*C21H22N3(1+)

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol; water Inert atmosphere;0.046 g
3-(2-azido-5-methylphenyl)pyridine
1296770-62-1

3-(2-azido-5-methylphenyl)pyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dichloromethane / 20 °C / Inert atmosphere
2: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve
3: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
4: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
5: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 20 °C / Inert atmosphere
2: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere
3: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
4: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
5: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
1-methyl-3-(2-azido-5-methylphenyl)pyridinium triflate
1296770-72-3

1-methyl-3-(2-azido-5-methylphenyl)pyridinium triflate

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve
2: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
3: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
4: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere
2: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
3: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
4: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
CF3O3S(1-)*C13H13N2(1+)
1296770-97-2

CF3O3S(1-)*C13H13N2(1+)

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
3: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
3-(2-amino-5-methylphenyl)pyridine
695185-44-5

3-(2-amino-5-methylphenyl)pyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: dichloromethane / 20 °C / Inert atmosphere
3.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve
4.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
6.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: dichloromethane / 20 °C / Inert atmosphere
3.1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere
4.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
6.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
2-bromo-p-toluidine
583-68-6

2-bromo-p-toluidine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere
2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: dichloromethane / 20 °C / Inert atmosphere
4.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve
5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere
2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: dichloromethane / 20 °C / Inert atmosphere
4.1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere
5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere
2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: dichloromethane / 20 °C / Inert atmosphere
4.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve
5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere
2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: dichloromethane / 20 °C / Inert atmosphere
4.1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere
5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere
7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere
View Scheme
2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine
21241-08-7

2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / 24 h / 120 °C
2.1: hydrogenchloride; water / ethanol / 1.5 h / 80 °C
2.2: pH 14
View Scheme
Multi-step reaction with 2 steps
1.1: toluene / 24 h / 120 °C
2.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
2.2: pH 14
View Scheme
2-methyl-5-(2-[N-nitroso-(2-methylphenyl)amino]ethyl)pyridine

2-methyl-5-(2-[N-nitroso-(2-methylphenyl)amino]ethyl)pyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
1.2: 12 h / 60 °C / Inert atmosphere
2.1: toluene / 24 h / 120 °C
3.1: hydrogenchloride; water / ethanol / 1.5 h / 80 °C
3.2: pH 14
View Scheme
Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium hydride / N,N-dimethyl-formamide; toluene / 10 h / 80 °C
1.2: 2 h / 110 °C
1.3: pH 9
2.1: sulfur / 7 h / 110 °C
3.1: sodium hydroxide; water / ethanol / 17 h / 80 °C
3.2: pH 2
4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C
5.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C
6.1: hydrogenchloride / water / 30 °C
6.2: 1 h / 0 - 20 °C
6.3: 1 h
7.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
7.2: 12 h / 60 °C / Inert atmosphere
8.1: toluene / 24 h / 120 °C
9.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
9.2: pH 14
View Scheme
p-toluidine
106-49-0

p-toluidine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C
2.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C
3.1: hydrogenchloride / water / 30 °C
3.2: 1 h / 0 - 20 °C
3.3: 1 h
4.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
4.2: 12 h / 60 °C / Inert atmosphere
5.1: toluene / 24 h / 120 °C
6.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
6.2: pH 14
View Scheme
2-(6-methylpyridin-3-yl)acetic acid
19733-96-1

2-(6-methylpyridin-3-yl)acetic acid

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C
2.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C
3.1: hydrogenchloride / water / 30 °C
3.2: 1 h / 0 - 20 °C
3.3: 1 h
4.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
4.2: 12 h / 60 °C / Inert atmosphere
5.1: toluene / 24 h / 120 °C
6.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
6.2: pH 14
View Scheme
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulfur / 7 h / 110 °C
2.1: sodium hydroxide; water / ethanol / 17 h / 80 °C
2.2: pH 2
3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C
4.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C
5.1: hydrogenchloride / water / 30 °C
5.2: 1 h / 0 - 20 °C
5.3: 1 h
6.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
6.2: 12 h / 60 °C / Inert atmosphere
7.1: toluene / 24 h / 120 °C
8.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
8.2: pH 14
View Scheme
N-(4-methylphenyl)-2-(6-methylpyridin-3-yl)acetamide
1229621-59-3

N-(4-methylphenyl)-2-(6-methylpyridin-3-yl)acetamide

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C
2.1: hydrogenchloride / water / 30 °C
2.2: 1 h / 0 - 20 °C
2.3: 1 h
3.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
3.2: 12 h / 60 °C / Inert atmosphere
4.1: toluene / 24 h / 120 °C
5.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
5.2: pH 14
View Scheme
4-methyl-N-(2-(6-methylpyridin-3-yl)ethyl)aniline
21241-10-1

4-methyl-N-(2-(6-methylpyridin-3-yl)ethyl)aniline

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 30 °C
1.2: 1 h / 0 - 20 °C
1.3: 1 h
2.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
2.2: 12 h / 60 °C / Inert atmosphere
3.1: toluene / 24 h / 120 °C
4.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
4.2: pH 14
View Scheme
4-methyl-N-[2-(6-methylpyridin-3-yl)ethyl]-N-nitrosoaniline
21241-09-8

4-methyl-N-[2-(6-methylpyridin-3-yl)ethyl]-N-nitrosoaniline

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
1.2: 12 h / 60 °C / Inert atmosphere
2.1: toluene / 24 h / 120 °C
3.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
3.2: pH 14
View Scheme
4-[(6-methyl-pyridin-3-yl)-thioacetyl]-morpholine
19733-95-0

4-[(6-methyl-pyridin-3-yl)-thioacetyl]-morpholine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / ethanol / 17 h / 80 °C
1.2: pH 2
2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C
3.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C
4.1: hydrogenchloride / water / 30 °C
4.2: 1 h / 0 - 20 °C
4.3: 1 h
5.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere
5.2: 12 h / 60 °C / Inert atmosphere
6.1: toluene / 24 h / 120 °C
7.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux
7.2: pH 14
View Scheme
1-Methyl-4-piperidone
1445-73-4

1-Methyl-4-piperidone

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 20 - 55 °C / Industry scale
1.2: 2.5 h / 5 - 45 °C / pH 12.4 / Industry scale
2.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C
View Scheme
p-tolylhydrazine hydrochloride
637-60-5

p-tolylhydrazine hydrochloride

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 20 - 55 °C / Industry scale
1.2: 2.5 h / 5 - 45 °C / pH 12.4 / Industry scale
2.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C
View Scheme
N-4-methylphenylhydrazine
539-44-6

N-4-methylphenylhydrazine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C
2: hydrogenchloride / isopropyl alcohol / 0.25 h
View Scheme
5-bromo-2-methylpyridine
3430-13-5

5-bromo-2-methylpyridine

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: butyl magnesium bromide; methyllithium / tetrahydrofuran / 0.5 h / -10 - 0 °C
1.2: 1 h
1.3: 1 h / 40 °C
2.1: thionyl chloride; sodium hydroxide / Isopropyl acetate
2.2: 4 h / 50 °C
3.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C
View Scheme
Multi-step reaction with 4 steps
1.1: butyl magnesium bromide; methyllithium / tetrahydrofuran / 0.5 h / -10 - 0 °C
1.2: 1 h
1.3: 1 h / 40 °C
2.1: thionyl chloride; sodium hydroxide / Isopropyl acetate
2.2: 4 h / 50 °C
3.1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C
4.1: hydrogenchloride / isopropyl alcohol / 0.25 h
View Scheme
1-(6-methylpyridin-3-yl)ethanol maleate

1-(6-methylpyridin-3-yl)ethanol maleate

dimebon
3613-73-8

dimebon

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride; sodium hydroxide / Isopropyl acetate
1.2: 4 h / 50 °C
2.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride; sodium hydroxide / Isopropyl acetate
1.2: 4 h / 50 °C
2.1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C
3.1: hydrogenchloride / isopropyl alcohol / 0.25 h
View Scheme
Conditions
ConditionsYield
In ethanol at 45 - 50℃;93.9%
dimebon
3613-73-8

dimebon

Latrepirdine dihydrochloride

Latrepirdine dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In acetone at 45 - 65℃; for 0.666667h; Inert atmosphere;84%
With hydrogenchloride In methanol; water at 0℃; for 2h; pH=2 - 3;83%
With hydrogenchloride In methanol at 0℃; for 2h; pH=2 - 3;83%
With hydrogenchloride In methanol; water at 20℃; for 2h;70%
iodomethyl diisopropylcarbamate
353736-55-7

iodomethyl diisopropylcarbamate

dimebon
3613-73-8

dimebon

2-(((diisopropylcarbamoyl)oxy)methyl)-5-(2-(1-(((diisopropylcarbamoyl)oxy)methyl)-6-methylpyridin-1-ium-3-yl)ethyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium diiodide

2-(((diisopropylcarbamoyl)oxy)methyl)-5-(2-(1-(((diisopropylcarbamoyl)oxy)methyl)-6-methylpyridin-1-ium-3-yl)ethyl)-2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium diiodide

Conditions
ConditionsYield
In ethyl acetate at 20℃;39%
iodomethyl diisopropylcarbamate
353736-55-7

iodomethyl diisopropylcarbamate

dimebon
3613-73-8

dimebon

2-(((diisopropylcarbamoyl)oxy)methyl)-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium iodide
1402916-48-6

2-(((diisopropylcarbamoyl)oxy)methyl)-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium iodide

Conditions
ConditionsYield
In ethyl acetate at 20℃;15%
dimebon
3613-73-8

dimebon

2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-1H-pyrido[4,3-b]indole N,N'-dioxide
1147893-49-9

2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-1H-pyrido[4,3-b]indole N,N'-dioxide

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid In water at 65 - 70℃; for 20h;
dimebon
3613-73-8

dimebon

C21H21N3O3
1147893-75-1

C21H21N3O3

Conditions
ConditionsYield
With selenium(IV) oxide In pyridine at 80℃; for 48h;
dimebon
3613-73-8

dimebon

2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2-oxide
1147893-84-2

2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 25℃; for 24h;
dimebon
3613-73-8

dimebon

C21H31B2N3

C21H31B2N3

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 20℃;
dimebon
3613-73-8

dimebon

(4aRS,9bSR)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole trihydrobromide

(4aRS,9bSR)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole trihydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate; trifluoroacetic acid / 3 h / 20 °C
1.2: pH 10 - 10.5
2.1: hydrogen bromide / ethanol; water / 0.5 h
View Scheme
dimebon
3613-73-8

dimebon

(4aRS,9bSR)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

(4aRS,9bSR)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

Conditions
ConditionsYield
Stage #1: dimebon With sodium tetrahydroborate; trifluoroacetic acid at 20℃; for 3h;
Stage #2: With sodium hydroxide In water pH=10 - 10.5; stereoselective reaction;
dimebon
3613-73-8

dimebon

(4aRS,9bRS)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole trihydrobromide

(4aRS,9bRS)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole trihydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: borane-THF / tetrahydrofuran / 20 °C
2.1: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux
2.2: pH 10 - 10.5
3.1: hydrogen bromide / ethanol; water / 0.5 h
View Scheme
dimebon
3613-73-8

dimebon

(4aRS,9bRS)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

(4aRS,9bRS)-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: borane-THF / tetrahydrofuran / 20 °C
2.1: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux
2.2: pH 10 - 10.5
View Scheme
dimebon
3613-73-8

dimebon

2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrobromide

2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate; trifluoroacetic acid / 3 h / 20 °C
1.2: pH 10 - 10.5
2.1: hydrogen bromide / ethanol; water / 0.5 h
3.1: oxygen / ethanol
View Scheme
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