The present work describes the incorporation of finely divided and well-dispersed Au species into SBA-15 mesoporous silica functionalized with mercaptopropyl groups, and the catalytic activity of the resulting Au-materials in the liquid phase oxidation of cyclohexene with molecular oxygen at atm...
New 4-{2-[3-(diethylamino)phenoxy]ethoxy}phthalonitrile 3 was obtained from 2-[3-(diethylamino)phenoxy]ethanol 1 and 4-nitrophthalonitrile 2 with K2CO3 in DMF at 50 °C. The novel iron(II) and cobalt(II) phthalocyanine complexes 4 and 5 were prepared by the reaction of the phthalonitrile derivat...
Peripherally tetra-substituted cobalt(II) and iron(II) phthalocyanines bearing [2-(4-methoxyphenoxy)ethoxy] groups have been synthesized and their structures have been verified by IR, 1H and 13C NMR, mass and UV–vis spectroscopy techniques. Fe(II) and Co(II) phthalocyanine complexes were tested...
Six new polyoxygenated seco-cyclohexenes, artahongkongenes A–F (1–6), together with six known analogues (7–12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their c...
Silver triflate promotes the 6-exo-dig mode cyclization of the N-(2-ethynylphenyl)thioureas, which were easily obtained from the o-ethynylphenyl isothiocyanates and the primary amines, to provide the 2-imino-4-methylidene-1H-benzo[d][1,3]thiazines as the sole product in excellent yields. The sec...
Rhodium complexes RhH(PPh3)4 and Rh(acac)(CH2CH2)2 catalyze sulfuration of isonitrile with sulfur giving isothiocyanates in high yields. The metal-catalyzed reaction is rapid in refluxing acetone, and completes within 3 h in most cases. The reaction exhibits induction period, which disappeared b...
2-Iminothiazole, an isoform of 2-aminothiazole, is a scaffold of synthetic and medicinal significance. We have reported an efficient method by which alkyl group of 2-alkyliminothiazoles is changed into other alkyl groups by isothiocyanates. In this article, a detailed mechanistic aspect, and the...
Alcohols undergo dehydration in a one-pot procedure when the alkoxide, formed by treating the starting alcohol dissolved in toluene with NaH, reacts with phenyl isothiocyanate and the resulting sodium carbonimidothioate salt is heated overnight at 200 °C. The phenyl isothiocyanate dehydration y...
The cheap, readily available and air stable catalyst was used as the desulfurization agent for the conversion of aniline to isothiocyanates in one pot two step reaction under mild reaction conditions.
The adsorption and structure of cyclohexyl isothiocyanate (CHIT) on gold surfaces has been investigated by surface-enhanced Raman scattering (SERS) and scanning tunneling microscopy (STM). Depending on the concentration, the spectral changes of the NCS stretching vibration on gold nanoparticles ...
2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones...
The 3,5-dichlorobenzoyl-substituted 2-deoxy-d-ribose-1-phosphate derivative, designated Cf2891, was found to inhibit a variety of pyrimidine and purine nucleoside phosphorylases (NPs) with preference for uridine- and inosine-hydrolyzing enzymes [uridine phosphorylase (UP; EC 2.4.2.3), pyrimidine...
A new series of 2-amino, 4-azepanone, 5-aryl substituted derivatives of pyrimidine compounds were synthesized for the first time from the commercially available 2-amino-4-hydroxypyrimidine. The key step in the reaction is a conceptually new single step palladium catalyzed cross coupling along wi...
Based on a previously identified HCV replication (replicase) inhibitor 1, SAR efforts were conducted around the pyrimidine core to improve the potency and pharmacokinetic profile of the inhibitors. A benzothiazole moiety was found to be the optimal substituent at the pyrimidine 5-position. Due t...
The review deals with the pharmaceutically and agrochemically important group of 1,2,4-triazolo[1,5-a]pyrimidines (TPs) and covers relevant literature published from about 2006 through 2018. The synthetic section describes the formation of TPs from both aminotriazoles and pyrimidine derivatives ...
In this paper, three bismuth(III) and diorganotin(IV) complexes based on bis(2-acetylpyridine) thiocarbonohydrazone (H2L) have been fully designed. The tests of the complexes on inhibiting human hepatocellular carcinoma HepG2 cells growth in vitro revealed that the complexes have higher activity...
The syntheses, physico-chemical and microbiological properties of the ligand, 2-acetylpyridine-aminoguanidine dihydrogensulfate monohydrate and its five complexes with Cu(II) are described. The compounds were characterized by single crystal X-ray crystallography. Common fragments encountered in ...
Cobalt(III) complexes [Co(L1)2]Cl·CH3OH·0.5H2O (1), [Co(L2)2]Cl·1.5H2O (2), [Co(L3)2]Cl·2H2O (3) and [Co(L4)2]Cl·3.5H2O (4) were obtained with 2-acetylpyridine-N(4)-phenylthiosemicarbazone (HL1), 2-acetylpyridine-N(4)-para-chlorophenylthiosemicarbazone (HL2), 2-acetylpyridine-phenylhydrazon...
The first employment of 2-acetylpyridine hydrazone in lanthanide(III) chemistry has led to dinuclear complexes with four bridging acetate groups of two different types and chelating 2-acetylpyridine hydrazone ligands.
The reaction of 2-acetylpyridine-aminoguanidine dihydrogenchloride (L·2HCl) with Zn(II) and Cd(II) ions, in the presence of deprotonating agent (LiOAc) and without it, yielded two types of complexes, i.e. neutral [Zn(L)Cl2]·H2O and [Cd(L)Cl2] and anionic complexes [H2L][ZnCl4]·H2O and [H2L]2[...
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