In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for ...

MP2 and density functional theory calculations have been carried out on β-d-neocarrabiose and its monohydrate in order to determine the conformational preferences of these molecules in the gas phase and in solvent. Relaxed iso-energetic maps were first obtained using B3LYP/6-31G(d). Then, the l...

An electrochromic thin film of the conducting polymer, poly(5,6-dimethoxyindole-2-carboxylic acid) (PDMICA), was prepared by electropolymerization. The transport phenomena of anions, cations, and water molecules through the film of PDMICA were studied in the electrolytes of lithium bis(trifluoro...

With the rising popularity of fluorescent lighting, simple and efficient methods for the decontamination of discarded lamps are needed. Due to their mercury content end-of-life fluorescent lamps are classified as hazardous waste, requiring special treatment for disposal. A simple wet-based decon...

In recent years, the development of 3D printing in flow analysis has allowed the creation of new systems with various applications. Up to now, 3D printing was mainly used for the manufacture of small units such as flow detection cells, preconcentration units or mixing systems. In the present stu...

In this study, a cloud point extraction (CPE) method for the extraction and preconcentration of cadmium was developed with its determination by slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS). Method developed is based on the reaction of cadmium with diphenylcarbazone to form...

An extensive medicinal chemistry campaign and subsequent SAR studies led to the discovery of the highly potent and selective JAK1/3 inhibitor R545. To support advanced pre-clinical DMPK studies of R545, the isotopically labeled versions of the drug and its metabolite R935 were required. Herein, ...

Higher plants acclimate to various light environments by changing the antenna size of a light-harvesting photosystem. The antenna size of a photosystem is partly determined by the amount of chlorophyll b in the light-harvesting complexes. Chlorophyllide a oxygenase (CAO) converts chlorophyll a t...

Nitric oxide (NO) has a general inhibitory effects on chlorophyll biosynthesis, especially to the step of 5-aminolevulinic acid (ALA) biosynthesis and protochlorophyllide (Pchlide) to chlorophyllide (Chlide) conversion (responsible by the NADPH:Pchlide oxidoreductase POR). Previous study suggest...

In this paper we report the polyallylamine-chlorophyllide (PAH-Chl) derivatized spherical gold and silver nanoparticles (AuNp, AgNp). The TEM micrographs showed that zero-valence Au and Ag nanoparticles are stable and well-dispersed in solution. The AuNp (∼25 nm) are bigger than the AgNp (∼20 ...

Chlorophyllide a oxygenase (CAO) that converts chlorophyllide a to chlorophyllide b was overexpressed in tobacco to increase chlorophyll (Chl) b biosynthesis and alter the Chl a/b ratio. Transgenic plants along with their wild-type cultivars were grown in low and high light intensities. In low l...

A pool of chlorophyllide b has been detected in greening cucumber cotyledons. This pool exhibited the same spectrofluorometric properties as that of Chl b in diethyl ether at 298 and 77 K (Rebeiz, C.A., Belanger, F.C., Freyssinet, G. and Saab, D.G. (1980) Biochim. Biophys. Acta 590, 234–247) bu...

Chlorophyllide a is a metabolite late in the biosynthesis of chlorophylls and bacteriochlorophylls. Isolation procedures for chlorophyllide a from Rhodobacter capsulatus CB1200 and barley (Hordeum vulgare L.) are described and compared. R. capsulatus CB1200 is a double mutant in the bacteriochlo...

Chlorophylls a,b and chlorophyllides a,b were isolated from pea chloroplasts as pheophorbides a,b following the administration of [14C]δ-aminolevulinic acid. Relative pool sizes suggest that chlorophyllide b precedes chlorophyll b and does not arise from the latter by the action of chlorophyllase.

Divinyl-chlorophyllide a (DV-Chlide a) is a universal precursor for chlorophyll or bacteriochlorophyll biosynthesis in all photosynthetic organisms. Previous mutational analyses revealed that BciA works for reduction of the C8-vinyl group of DV-Chlide a. Chlorophyllide oxidoreductase (COR) reduc...

Chlorophyllide b and four chemically different chlorophyll b specieis, chlorophyllide b esterified with geranylgeraniol, dihydrogeranylgeraniol, tetrahydrogeranylgeraniol and phytol have been detected in addition to the same derivatives of chlorophyll a in the greening cotyledons of cucumber. Th...

The chlorophyllide b derivatized polyallylamine (PAAChl) was synthesized. The resulting fluorescent polymer presented a high emission quantum yield, very stable in time. The polymer formed a hydrogel when treated with carbon dioxide that was characterized by Raman spectroscopy and solid-state NM...

The location of the acidic proton and the skeletal conformations of sparteine, α-isosparteine, and β-isosparteine monoperchlorates have been investigated by means of infrared spectroscopy in the 2840–2600 cm−1 and 2400–2000 cm−1 regions.

Four epi N-oxides of sparteine and its derivatives were prepared (13α-hydroxysparteine epi N-oxide (3) and 13α-hydroxylupanine N-oxide (5) for the first time) and their 1H and 13C NMR spectra were assigned using two-dimensional techniques. As sparteine (1) and 13α-hydroxysparteine (10) are co...

The 13C NMR spectra of six sparteine derivatives were analysed. In four of them, the substituent phenyl, methyl or cyano was in the external A ring of the molecule at C(2), while in the other two, the substituent was attached to C(15) in ring D. The analysis was based on a comparison of the spec...