Aldose reductase (ALR2), a NADPH-dependent reductase, is the first and rate-limiting enzyme of the polyol pathway of glucose metabolism and is implicated in the pathogenesis of secondary diabetic complications. In the last decades, this enzyme has been targeted for inhibition but despite the num...

Binding sites for t-[35S]butylbicyclophosphorothionate ([35S]TBPS) were detected in well-washed membranes from the brain of trout; γ-aminobutyric acid (GABA) acted as an uncompetitive inhibitor of the binding of [35S]TBPS, decreasing both the number of binding sites and the affinity of TBPS. In...

GABAA receptors (GABAARs) are ligand-gated ion channels that mediate inhibitory neurotransmission in the central nervous system (CNS). They are members of the Cys-loop receptor family and display marked structural and functional heterogeneity. Many GABAARs receptor subtypes are allosterically mo...

Neurosteroids and micronutrient are known to possess neuromodulator and neuroprotective activities. The present study was designed to investigate the effect of 4′-chlorodiazepam (4CD) or ascorbic acid (Vit C) on phosphamidon (PM) induced modulation of cognitive function and oxidative stress in ...

BackgroundThe Translocator Protein (TSPO) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. Administration of 4-chlorodiazepam (4-CLD), a TSPO ligand, has been shown to confer acute cardioprotective effec...

The translocator protein of 18 kDa (TSPO) is located in the outer mitochondrial membrane and is involved in the cholesterol transport into the mitochondria and in the regulation of steroidogenesis, mitochondrial permeability transition pore opening and apoptosis. TSPO ligands have been investiga...

The translocator protein 18 kDa (TSPO) is located in the outer mitochondrial membrane and is involved in the cholesterol transport into the mitochondria and in the regulation of steroidogenesis and other mitochondrial functions. It is known that steroid hormones, such as estradiol, testosterone ...

The translocator protein (TSPO) is an outer mitochondrial membrane protein involved in the transport of cholesterol into the mitochondria, which is the first step for the synthesis of steroid hormones, as well as in the regulation of mitochondrial permeability transition pore opening and apoptos...

BackgroundThe present study evaluated the antioxidant, antinociceptive and anti-edematogenic effects of Se-[(2,2-dimethyl-1,3-dioxolan-4-yl) methyl] 4-chlorobenzoselenolate (Se-DMC).

Pd2+-catalyzed aminocarbonylation of O-2,3-butadienyl 1 and O-3,4-pentadienyl carbamates 5 stereoselectively provides 4-(1-methoxycarbonylviny])-1,3-oxazolidin-2-ones 2 and 4-(1-methoxy-carbonylvinyl)-1,3-oxazin-2-ones 6, respectively, in high yields.

The palladium Pd(PPh3)4-catalyzed coupling reaction of allenyl N-tosylcarbamates with hypervalent iodonium salts afforded the cyclized trans-5-substituted oxazolidinones, 3-oxazin-2-ones, and higher membered carbamates under mild conditions.

Lithiated anions derived from (alkenyl)pentamethyl phosphoric triamides as homoenolate equivalents are used in the reaction with halogenated acetal and ketal giving regioselectively the γ-alkylation adducts. Chemoselective acidic hydrolysis of the enephosphoramide moiety in the presence of acet...

Reaction of five N,N′-bis(aryl)pyridine-2,6-dicarboxamides (H2L-R, where H2 denotes the two acidic protons and R (R = OCH3, CH3, H, Cl and NO2) the para substituent in the aryl fragment) with [Ru(trpy)Cl3](trpy = 2,2′,2″-terpyridine) in refluxing ethanol in the presence of a base (NEt3) affor...

Vapor phase synthesis of 2,6-bis(4-methylpheny)pyridine (2,6-BP), an important drug intermediate, was carried out by the cyclization of 4-methyl acetophenone (4-MAP), ethanol, formaldehyde and ammonia over different classes of molecular sieves, viz. HY, HZSM-5, Hβ and Al-MCM-41. The predominant...

Charge transport in 5,5′-(2,6-di-tert-butylanthracene-9,10-diyl)bis(2-p-tolyl-1,3,4-oxadiazole) is investigated as a function of temperature and organic layer thickness. The thickness dependence of the current indicates towards the trap charge limited conduction (TCLC) with a field and temperat...

Three ruthenium(II) complex catalysts bearing 2,6-bis(tetrazolyl)pyridine were synthesized, structurally characterized, and applied in the transfer hydrogenation of ketones. Their different catalytic activities were attributed to the different phosphine ligands on the 4-chloro-2,6-bis(1-(p-tolyl...

In this study, the methyl ester production and characterization from safflower oil (SO) was examined. The seed were collected from Yozgat-Turkey and SO was obtained from safflower seeds using screw press. SO was transesterified with methanol and NaOH to obtain safflower oil methyl ester (SOME). ...

A new vacuum ultraviolet (VUV) detector for gas chromatography was recently developed and applied to fatty acid methyl ester (FAME) analysis. VUV detection features full spectral acquisition in a wavelength range of 115–240 nm, where virtually all chemical species absorb. VUV absorption spectra...

The analysis of the total methyl esters of fatty acids from the extracts of Gracilaria birdiae, Gracilaria caudata, Gracilaria cerviconis, Gracilaria domingensis collected in the coast of Paraíba, Northeast Brazil, as well as their chemotaxonomic significance are herein reported for the first t...

Castor oil has been widely used as raw material to obtain compounds such as paints, solvents, rubbers, polyurethane polymers and chemical inputs. Then, one highlighted route is thermal cracking of castor oil to produce bio-oil, mainly composed of heptaldehyde and methyl undecenoate, which are us...