A new methodology was developed for the synthesis of hexahydro-1H-pyrido[2,3-b]indol-2-one scaffolds via a sequential Michael addition/amidation/reductive cyclization process. A wide variety of products bearing a hexahydro-1H-pyrido[2,3-b]indol-2-one core with varying degrees of substitution aro...

The 7-endo Friedel–Crafts cyclization of vinyloxiranes, which have a nitrogen atom at the linker between the aromatic ring and the epoxide, was found to proceed regio- and stereoselectively to afford polyfunctional tetrahydro-1-benzazepine and tetrahydro-2-benzazepine.

Readily available aromatic prolinamides obtained from the acid chloride of proline hydrochloride and anilines induce large enantiomeric excesses in intramolecular aldol condensations. Imidazolidinones derived from the reaction of the catalyst and enamines have been found as intermediates in thes...

Three series of novel 2-benzylthio-4-chloro-5-R1-benzenesulfonamides bearing the N-(benzoxazol-2-yl) (10–19), N-(benzothiazol-2-yl) (20–21) or N-(1,3-dihydro-2H-benzimidazol-2-ylidene) (22–25) moiety were synthesized by reacting N-(2-benzylthio-4-chloro-5-R1-benzenesulfonyl)cyanamide potassiu...

A mild and efficient oxidative synthesis of isoindolinones has been realized by Rh(III)-catalyzed C–H activation of benzamides and [4 + 1] coupling with propargyl alcohols. This coupling system proceeds with broad substrate scope and mild conditions and provides a new approach to access the use...

Soil organic matter (SOM) is important for plant growth and production. Conventional analyses of SOM are expensive and time-consuming. Hyperspectral remote sensing is an alternative approach for SOM estimation. In this study, the diffuse reflectance spectra of soil samples from Qixia City, Shand...

This article first reported that a simple synthesis of carbon dots (UCDs) by pyrolysis of uric acid was proposed. The excitation wavelength was 350 nm and the emission wavelength was 402 nm for the synthesized UCDs. And the corresponding fluorescence quantum yield was 52.06%. The obtained UCDs c...

One of the important features of heavy oil reservoirs is their high viscosity, which reduces the recovery factor of oil in these reservoirs. Thermal methods have traditionally been used for viscosity reduction in enhanced recovery process (EOR). However, these methods are not justifiable due to ...

Enzymes of CYP74 family play the central role in the biosynthesis of physiologically important oxylipins in land plants. Although a broad diversity of oxylipins is known in the algae, no CYP74s or related enzymes have been detected in brown algae yet. Cloning of the first CYP74-related gene CYP5...

Background: TB-402, a human monoclonal antibody that partially inhibits Factor VIII activity (FVIII:C), is being developed as a long-acting antithrombotic agent.Objectives: The primary goal of this study was to investigate the tolerability of TB-402 in healthy male volunteers. Secondary objectiv...

The accumulation of excess white adipose tissue (WAT) has harmful consequences on metabolic health. WAT browning confers beneficial effects on adiposity, insulin resistance and hyperlipidaemia. In this study, it was found out that circNrxn2 sponged miR-103, and enhanced FGF10 levels in HFD mice ...

SummaryBrown adipose tissue (BAT) is rich in mitochondria and plays important roles in energy expenditure, thermogenesis, and glucose homeostasis. We find that levels of mitochondrial protein succinylation and malonylation are high in BAT and subject to physiological and genetic regulation. BAT-...

Dye wastewaters are considered as major pollutants to surface waters. The dye C.I. Direct Black 38 is one of the most important azo dyes used in dying industry and contaminated waters containing this harmful material are produced in large volumes. The purpose of this study is investigation remov...

Because of the lack of function-blocking anti-integrin antibodies that react with nonprimate species, the study of the role of integrins in in vivo animal models of atherosclerosis has been limited. In contrast, peptides or small molecules have shown less species specificity and thus may be bett...

Phenol and its derivatives are highly hazardous chemicals profoundly dangerous even at low levels. Hence the management of phenol polluted wastewater represents major environmental challenges. This study investigates the growth and the phenol utilization behavior of microalga DEE 01 isolated fro...

A series of novel pyrazolo[1,5-a]pyrimidine derivatives bearing nitrogen mustard moiety were designed, synthesized and evaluated for their antiproliferative activities against five human cancer cell lines (A549, SH-SY5Y, HepG2, MCF-7 and DU145) in vitro. Among these compounds, 13b exhibited pote...

(2-Chlorobenzoyloxy)copper(I) exhibited high activity towards the challenging amination of 2-amino pyrimidines with aryl halides. Herein, secondary and tertiary amines were selectively produced by using potassium phosphate and sodium-t-butoxide. Potassium phosphate favored the formation of secon...

Alginate and carrageenan bio-polymers have been proved to be, only, good sorbents of cationic dyes. In this study, we reported the synthesis of [λ‑carrageenan‑calcium phosphate] and [sodium alginate‑calcium phosphate] modified with dimethyl diallyl ammonium chloride and diallylamin co-polymer, ...

To achieve high-performance thermosets, three diallyl-containing main-chain type benzoxazine polymers, (MCBP) were prepared from Mannich condensation of 2,2′-diallyl bisphenol A, paraformaldehyde, and three diamines: 4,4′-diaminodiphenylmethane (DDM), 4,4′-oxydianiline (ODA), and 2,2′-bis(4-...

Complexes of naturally occurring hydroxynaphtho-quinone, lapachol (2-hydroxy-3(3-methyl-2-buthenyl)-1,4-naphthoquinone = HL) with Co(II), Ni(II) and Cu(II) have been prepared by reaction of the corresponding acetates with the ligand (HL) in ethanol. The molecular and crystal structures were dete...