Electrical transport of pure and tetrafluoro-tetracyano-quinodimethane doped 4,4′,4″-tris(N-3-methylphenyl-N-phenylamino)triphenylamine (m-MTDATA) films have been studied at various temperatures and doping concentrations. Pure films show space charge limited conduction with field and temperatu...

ObjectiveE-cigarettes are the most prevalent tobacco product used by adolescents. We sought to determine whether the presence of flavoring and/or the presence of nicotine at the first e-cigarette exposure predicted progression to current e-cigarette use (use in past 30 days) as well as escalatio...

Neoplastic metastasis is a major process where tumor cells migrate from the primary tumor and colonize at other parts of our body to form secondary tumor. Cancer incidences are rising and novel anti-neoplastic compounds with new mechanism of actions are essential for preventing cancer related de...

Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In this work, a series of cis- and trans-pyrrolidine bisarylethenesul...

Duloxetine is a new antidepressant candidate drug with inhibitory effects on norepinephrine and serotonin (5-HT) uptake. In the present study, simultaneous monitoring of the inhibition of 5-HT uptake by platelets and plasma drug concentrations was carried out in healthy volunteers during and aft...

Depressed patients suffer from cognitive dysfunction, including memory deficits. Acute serotonin (5-HT) depletion impairs memory and mood in vulnerable patients. The investigational multimodal acting antidepressant vortioxetine is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor pa...

The purpose of this study was to compare the cost-effectiveness of duloxetine versus routine treatment in management of diabetic peripheral neuropathic pain (DPNP). Two hundred thirty-three patients with DPNP who completed a 12-week, double-blind, placebo-controlled, randomized, multicenter dulo...

Cecropin 3 (Ccrp3) is an antimicrobial peptide from Anopheles albimanus, which is expressed during Plasmodium berghei infection. Here, we report that synthetic Ccrp3, aside from antibacterial activity, also shows cardio regulatory functions. In rats, Ccrp3 significantly diminishes blood pressure...

This study was conducted to determine the effects of the antimicrobial peptide cecropin on performance and intestinal health in piglets. Newly weaned barrows were randomly assigned to one of three treatments (n = 8), including a corn-soybean basal diet or similar diets supplemented with antibiot...

Cationic elastin-like polypeptides (CELP) are thermally responsive polypeptides that undergo an inverse temperature phase transition, and the recombinant CELP fusion proteins may be purified by inverse transition cycling (ITC). To obtain high-purity antimicrobial peptide cecropin AD (CAD), CELP ...

A sensitive and selective method for the determination of alcohol ethoxylates (AEOs) and alkylphenol ethoxylates (APEOs) using solid-phase extraction (SPE) and LC–MS/MS was developed and applied to the analysis of water samples. All AEO and APEO homologues, a total of 152 analytes, were analyze...

The human placental JEG-3 and JAR choriocarcinoma cell lines have been used as placental models for the study of aromatase (CYP19) activity and endocrine functions. In the present study, 21 organochlorines (OCs) mediated decreases in aromatase activity and protein and DNA content and increases i...

Non-enzymatic reactions of the 3,4-oxide of 2,2′,5,5′-tetrachlorobiphenyl (TCB) with methionine or N-acetylmethionine in ethanol/neutral buffer at 37°C proceeded very slowly to yield an approx. 1 : 1 ratio of 3- and 4-methylthio-TCB. Under similar conditions reaction of TCB 3,4-oxide with cys...

High-pressure Raman spectra of l-tyrosine hydrochloride crystal were obtained from 1.0 atm to 7.0 GPa in the 90-1800 cm−1 spectral region. At atmospheric pressure, the Raman spectrum was obtained in the 50-3200 cm−1 spectral range and the assignment of the normal modes based on density functiona...

DL-lysine hydrochloride crystals were studied by Raman spectroscopy under hydrostatic pressure using a diamond anvil cell from ambient pressure up to 9.8 GPa in the spectral range from 1150 to 40 cm−1. Changes in the Raman spectrum were observed in all spectral regions analyzed. In particular, m...

Single-crystals of l-histidine hydrochloride monohydrate, C6H9N3O2·HCl·H2O, were studied by Raman spectroscopy as a function of pressure in a diamond anvil cell up to 7.5 GPa at room temperature over the spectral range 3450–30 cm−1. The effect of changing pressure on the vibrational spectrum ...

Because of the complex biological networks, many pathologic disorders fail to be treated with a molecule directed towards a single target. Thus, combination therapies are often necessary, but they have many drawbacks. An alternative consists in building molecules intended to interact with multip...

A series of titanium (IV) complexes (2, 5-7) stabilized by a substituted 2-hydroxybenzyl alcohols (1, 4) – were synthesized. Structures of complexes 6-7 were determined by X-ray diffraction. Titanium atom in the tetrameric complex 6 has an octahedral environment created by chlorine atom and fiv...

A chiral phosphoric acid-catalyzed Friedel–Crafts alkylation of o-hydroxybenzyl alcohols with 3-alkylindoles has been established, which was used to construct a biologically important diarylindol-2-ylmethane scaffold in high yields and with good enantioselectivities (up to 99% yield, 90:10 er)....

A simple route to polysubstituted benzofurans based on the domino reaction of commercial or easily available salicyl alcohols with N-protected furfurylamine has been designed and developed. The reaction was found to proceed with reasonable yields under heating of substrates in acetic acid in the...