We developed a paper-type electrode for the next-generation wearable devices by complementary hybridization of methyl cellulose and carbon nanotubes (CNTs). The large-scale hybrid paper was fabricated using an incomparably simple and low-cost solution process. Structural features, surface hydrop...

Methylcellulose/cellulose nanocrystal (MC/CNC) nanocomposite fibers showing high ductility and high modulus of toughness were prepared by a simple aqueous wet-spinning from corresponding nanocomposite hydrogels into ethanol coagulation bath followed by drying. The hydrogel MC aq. concentration w...

The effect of carboxyl methyl cellulose (CMC) on the flotation separation of scheelite from calcite using sodium oleate as collector was studied in this work. The results of flotation tests indicated that CMC could selectively depress the flotation of calcite. However, the addition of calcite st...

A small interfering RNA (siRNA) plasmid DNA (pYr-1.1-hU6-EGFP-siVEGF) was constructed and used for suppressing vascular endothelial growth factor (VEGF) expression and inhibiting tumor growth. Then, a (tyrosyl–seryl–leucine)–polyethyleneimine–poly(ethylene glycol) (YSL–PEI–PEG) conjugate w...

This study aimed to observe the effects of tyroserleutide (tyrosyl-seryl-leucine, YSL) on the survival time of mice transplanted with the ascitic fluid-type hepatocarcinoma H22, as well as the inhibitory effect of tyroserleutide on the human hepatocarcinoma Bel-7402 that was transplanted into nu...

Deltorphins show a high affinity and selectivity for δ opioid receptors. Analogs of deltorphins with substitution of Val5,6 residues with more hydrophobic lle5,6 appear to have a higher in vitro activity and selectivity than parent deltorphins. In our study, changes in the nociceptive threshold...

An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicit...

l-(+)-Homophenylalanine hydrochloride was synthesized from N-phthaloyl-l-(−)-asparitc anhydride 2 in three steps in 55% overall yield with 99% ee.

Mur ligases (MurC–MurF), a group of bacterial enzymes that catalyze four consecutive steps in the formation of cytoplasmic peptidoglycan precursor, are becoming increasingly adopted as targets in antibacterial drug design. Based on the crystal structure of MurD cocrystallized with thiazolidine-...

BackgroundThe genus Salmonella contains more than 2600 serovars. While most cause a self-limiting gastroenteritis, four serovars, S. Typhi, S. Paratyphi A, B and C, elicit typhoid, a potentially fatal systemic infection. Because of the prevalence in certain regions, such as South Asia, and the d...

Salmonella enterica serovar Typhimurium produces type 1 fimbriae with binding specificity to mannose residues. Elements involved in fimbrial structural biosynthesis, transport, and regulation are encoded by the fim gene cluster. FimZ, FimY, FimW, STM0551, and an arginine transfer RNA (fimU) were...

During culmination of Dictyostelium fruiting bodies, prespore and prestalk cells undergo terminal differentiation to form spores and a cellular stalk. A genomic fragment was isolated by random cloning that hybridizes to a 1.4-kb mRNA present during culmination. Cell type separations at culminati...

ObjectiveWe investigated effects of salazosulfapyridine (SASP) on the protein profile of cell surface (CS)-proteins of SW982, a human synovial sarcoma cell line, using biotinylation of CS-proteins and 2-dimensional fluorescence difference gel electrophoresis (2D-DIGE).

SummaryThe homeodomain is found in hundreds of transcription factors that play roles in fate determination via cell-autonomous regulation of gene expression. However, some homeodomain-containing proteins (HPs) are thought to be secreted and penetrate neighboring cells to affect the recipient cel...

I-POU, a POU domain nuclear protein that lacks two conserved basic amino acids of the POU homeodomain is coexpressed in the developing Drosophila nervous system with a second POU domain transcription factor, Cf1-a. I-POU does not bind to DNA but forms a POU domain-mediated, high affinity heterod...

In this study the rheological behaviour, air—liquid surface and liquid—liquid interfacial activities of solutions of water-soluble associative copolymers of sodium maleate/1-dodecene and sodium maleate/1-hexadecene are investigated with respect to the polymer concentration, temperature, salini...

Background5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness ...

The metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and r...

Imidazoacridinone C-1311 (Symadex®) is an antitumor agent which has been recommended for Phase II clinical trials a few years ago. Previously, it was shown experimentally that during the initial stage of its action C-1311 forms stable intercalation complexes with DNA duplexes. Herein, a NMR-deri...

In the current study, an efficient method had been developed to acquire the antioxidant hydrolysate of monkfish muscle protein (MPH) using trypsin by an orthogonal (L9(3)4) test. Under the optimum conditions of enzymolysis time 4 h, enzyme-to-substrate ratio (E/S) 2%, enzymolysis temperature 40 ...