Common carps (Cyprinus carpio) were exposed to syn- and anti-Dechlorane Plus (DP) isomers to investigate absorption, tissue distribution, and stereoselective bioaccumulation of DP isomers. The absorption efficiencies of anti-DP in the gastrointestinal system were higher than those of syn-DP. A l...

Dechlorane plus (DP) is found widely in environmental media. Determining DP concentrations in dust and hair and identifying relationships between the concentrations in dust and hair could improve our understanding of the effects of DP in humans. DP concentrations in 48 hair samples from male and...

RS-1541 is a 13-O-palmitoyl derivative of rhizoxin, an inhibitor of tubulin polymerization. RS-1541 has been shown to bind preferentially to plasma lipoproteins and to exhibit selective uptake by tumors in mice. We demonstrated that: (1) 99% of RS-1541 bound to human lipoproteins after incubatio...

Using the CCSD(T)/cc-pVDZ//B3LYP/6-311G(2d,2p) method, we investigated the detailed potential energy surfaces for the unimolecular dissociation reactions of chloromethyl peroxynitrate (CH2ClO2NO2). The results show that there are four most stable isomers of CH2ClO2NO2, named IS1, IS2, IS3 and IS...

Pulsed molecular beam Fourier transform microwave spectroscopy has been used in order to remove disagreements in previous assignments of the rotational spectra of (chloromethyl)cyclopropane and (chloromethyl)oxirane. For the latter, two rotameric forms have been detected in a supersonic jet. It ...

Three reactions occurring on the C3H4Cl potential energy surface (PES) were studied computationally using quantum chemistry and master equation/RRKM: CH2Cl + C2H2 → Products (1), CH2CHCHCl → Products (2), and CH2ClCHCH → Products (3). The results indicate low importance of the 1,3-Cl shift ch...

Photodynamic antimicrobial chemotherapy (PACT), as a novel and effective modality for the treatment of infection with the advantage of circumventing multidrug resistance, receives great attention in recent years. The photosensitizer is the crucial element in PACT, and cationic porphyrins have be...

Several heteroannulated pyridinones were prepared from the methyl esters of N-Boc-β,β-diheteroaryldehydroalanines by treatment with acetic acid. The latter were obtained by a bis-Suzuki coupling of a β,β-dibromodehydroalanine with heteroarylboronate compounds. The products were obtained in g...

The enantioselective synthesis of several 3-substituted isobenzofuranones has been developed through a new and flexible route. When combined with a catalytic amount of benzoic acid, quinidine thiocarbamate bifunctional catalysts have demonstrated their efficiency for the highly regioselective or...

The cetane number (CN), being related to ignition and combustion behavior, is a prime indicator of the quality of diesel fuels, including those derived from renewable resources such as biodiesel. While many effects of compound structure are known or have been postulated, experimental data have n...

Phthalate esters which are widely used as industrial chemicals have become widespread contaminants in the marine environment. However, little information is available on the interfacial behavior of phthalate esters in the seawater, where contaminants generally occur at elevated concentrations an...

A direct synthesis of 3-(bromomethylene)isobenzofuran-1(3H)-ones from 2-alkynylbenzoic acids is developed through a regioselective 5-exo-dig bromocyclization. The reaction proceeds smoothly with a broad substrate scope. The products can be further elaborated via a palladium-catalyze cross-coupli...

Model studies to develop a tetracyclization approach mimicking the proposed biosynthesis of the secodaphnane-type alkaloid longeracemine are described. These studies have culminated in the successful implementation of a 3H-pyrrole [4+2] cycloaddition that delivers a longeracemine-like azabicycle...

Exposure to high or repeated doses of methamphetamine can cause hyperthermia and neurotoxicity, which are thought to increase the risk of developing a variety of neurological conditions. Sigma receptor antagonism can prevent methamphetamine-induced hyperthermia and neurotoxicity, but the underly...

2-Aminoquinazolin-4(3H)-ones were previously discovered as perspective leads for antimalarial drug development targeting the plasmepsins. Here we report the lead optimization studies with the aim to reduce inhibitor lipophilicity and increase selectivity versus the human aspartic protease Cathep...

6-Butyl-4-hydroxyquinolin-2-(1H)-one (II) was synthesized by heating N, N′-bis (4-butylphenyl) malonamide (I) in polyphosphoric acid at 150–160 °C. This compound was then coupled with ten diazotized p-substituted aniline derivatives to synthesize the corresponding azo disperse dyes 1–10 in s...

The cycloheptyl-fused cobalt(II) chloride complexes, [2,3:5,6-{C4H8C(N(2-R1-4-R2-6-(CHPh2)C6H2))}2C5HN]CoCl2 (R1 = R2 = Me Co1, R1 = Me, R2 = CHPh2 Co2, R1 = Et, R2 = CHPh2 Co3, R1 = i-Pr, R2 = CHPh2 Co4, R1 = Cl, R2 = CHPh2 Co5, R1 = CHPh2, R2 = i-Pr Co6, R1 = CHPh2, R2 = t-Bu Co7, R1 = CHPh2, ...

A short, technically feasible route was developed for the synthesis of (S)2-(4-fluorophenyl)-3-methylbutanoic acid (S)-2 with an overall yield of 80% starting from 4-fluorophenylacetic acid. Asymmetric hydrogenation of the easily accessible unsaturated acid 3 in the presence of ruthenium(II) car...

A new and general one-pot synthetic method for C2-symmetric N,N′-aryl-disubstituted bis(oxazolidin-2-ones) has been developed. Highly regioselective intramolecular cyclization reactions of 2,3-di(methanesulfonyloxy)-1,4-dihydroxybutane with arylisocyanates in the presence of sodium hydride affo...

Diacylglycerol kinases (DGKs) attenuate diacylglycerol-induced protein kinase C activation during stimulated phosphatidylinositol turnover. This reaction also initiates phosphatidylinositol resynthesis. Two agents, 3-{2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2,3-dihydro-2-thioxo...