The sex-determining genes are found to be variable among different fish species. Yellow catfish (Pelteobagrus fulvidraco) is an important aquaculture fish species in China with XX/XY sex-determining type. Recently, YY super-male yellow catfish has been successfully produced by combining hormonal...

The artists' pigment zinc yellow is in general described as a complex potassium zinc chromate with the empirical formula 4ZnCrO4·K2O·3H2O. Even though the pigment has been in use since the second half of the 19th century also in large-scale industrial applications, the exact structure had...

Adsorption of basic dyes, basic blue 26 (BB26), basic green 1 (BG1), basic yellow 2 (BY2) and basic red 1 (BR1) onto activated carbon surfaces were investigated. Activated carbons (ACs) were produced by thermal treatment at 800 °C, oxidation with HNO3 6 M and chemical activation with H3PO4 at 4...

Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C...

Saponification occurring in paint layers of artworks represents a serious degradation process affecting the appearance and stability of paintings. Formation of metal soaps is mostly reported as a consequence of the interaction of lead white or zinc white with oil binder. We found the distinct sy...

The aim of this study was to investigate the adsorption of basic yellow, a cationic dye, from aqueous solution by natural stevensite, with 104 m2/g of specific surface area. The kinetics and the effects of several experimental parameters such as the pH of the solution, adsorbent dose and initial...

IntroductionTranslational inhibition of amyloid precursor protein (APP) by Posiphen has been shown to reduce APP and its fragments in cell culture, animal models, and mildly cognitively impaired patients, making it a promising drug candidate for the treatment of Alzheimer's disease.

An efficient approach to chiral α-hydroxy acid esters by Lewis acid-mediated asymmetric [1,5]-hydride shift and isomerization of 2-(3-pyrroline-1-yl)arylketone acid ester has been achieved in up to 96% yield and 94% ee. This protocol would be applied in the synthesis of chiral α-hydroxy acid d...

In order to investigate the biosynthesis of the carbon skeleton of trachelanthic acid a root culture of Eupatorium clematideum (Asteraceae) synthesising pyrrolizidine alkaloids (PAs) of the lycopsamine type was supplied with a mixture of [U-13C6]glucose and unlabelled glucose at a ratio of 1:20 ...

The electrophoretic mobility of an α-hydroxycarboxylic acid in electrolytes containing boric acid is very dependent on the degree of substitution at the α-carbon atom. A study of eighteen α-hydroxy acids shows clearly that the “gem-dialkyl” effect is operating to favour the formation of the...

4-Chloro-, 4-bromo- and 4-iodoserotonin derivatives were synthesized from 4-halo-5-oxyindoles, themselves derived from coumarins. Synthesis of the 4-iodoserotonins involved conjugate addition of an allyl group to a 5-iodocoumarin, followed by conversion of the allyl group into an aminoethyl unit...

Biotransformation of danazol (1) (17β-hydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole) with Cunninghamella blakesleeana yielded three new metabolites 2–4 and a known metabolite 5. These metabolites were identified as 14β,17β-dihydroxy-2-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2), ...

BackgroundAllogeneic stem cell transplantation (ASCT) represents the only option with a potential cure rate of 30% to 50% in myelodysplastic syndrome (MDS); however,

Myelofibrosis is a myeloproliferative neoplasm that is characterized by splenomegaly, profound symptom burden, and cytopenias. JAK inhibitor therapy offers improvements in splenomegaly, symptom burden, and potentially survival; however, cytopenias remain a significant challenge. Danazol has prev...

Fibrocystic Breast Disease (FBD) or Fibrocystic change (FC) affects about 60% of women at some time during their life. Although usually benign, it is often associated with pain and tenderness (mastalgia). The synthetic steroid danazol has been shown to be effective in reducing the pain associate...

Microporous zeolite NaX-FAU has been systemically evaluated for the oral delivery of the poorly water-soluble compound danazol. For this purpose, danazol-loaded zeolitic particles were prepared by the incipient wetness method and were characterized by means of N2 physisorption, X-ray diffraction...

Oral bioavailability of poorly water soluble (BCS II) drugs like danazol can be minimal without the necessary formulation strategies. Availability of in vitro physicochemical and in vivo pharmacokinetic studies can be valuable when designing these strategies but cannot reveal the drug-formulatio...

Claisen-Schmidt condensation of 2,3,4,9-tetrahydro-1H-carbazol-1-one with 3-bromo-4-methoxy benzaldehyde afforded the 2-(3'-bromo-4'-methoxybenzylidene)-2,3,4,9-tetrahydro-1H-carbazol-1-one 3. Compound 3 was allowed to react with different organic reactants, hydroxylamine hydrochloride...

The enantiomers of benzyl-(2-chloroethyl)-[2-(2-methoxyphenoxy)-1-methylethyl]amine hydrochloride (1, CM18) were synthesized and studied pharmacologically for their irreversible antagonism at rat vas deferens α-adrenoceptors. In addition, assignment of the absolute configuration of the two enan...

Corrosion inhibition of carbon steel in 1.0 M HCl was investigated in the absence and the presence of different concentrations of 1-(2-(4-chlorophenyl)-2-oxoethyl)pyridazinium bromide (CPEPB). This inhibitive action against the corrosion of carbon steel in 1.0 M HCl solution was investigated at ...