Five alk-2-enals - pent-2-enal, hex-2-enal, hept-2-enal, oct-2-enal and non-2-enal - produced by lipid peroxidation were tested for mutagenic activity in V79 Chinese hamster cells. At concentrations ranging from 0.003 to 0.3 mM all 5 alk-2-enals induced a dose-dependent increase in the frequency...

The thieno [3,4:3`,4`] benzo [b] pyranone (3b) and the thieno [3,4-c] quinoline (3c) are prepared via reacting 4-methylcoumarin-3-carbonitrile (9a) and 4-methyl-2-oxo-1,2-dihydroquinolin-3-carbonitrile (9b) with elemental sulphur. Similarly the thieno [3,4:3`,4`] naphtho [1,2-b] pyran (11) is pr...

Some derivatives of 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized using ethyl 2-aminothiophene-3-carboxylates as precursors in order to estimate their cytotoxicity, respectively proliferative activity.Thienopyrimidinones containing thiosemicarbazide as well as 1,3,4-thiad...

1.1. S-135, 2-(5-methylthien-3-y1)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one, binds to benzodiazepine receptors with a high affinity and shows pharmacological actions opposite to those of conventional benzodiazepine drugs.2.2. S-135 induced no convulsion in mice by itself, but selectively pot...

A 9-bit 135 MS/s SAR ADC utilizes a 1.5-bit acceleration method and a binary-scaled recombination weighting method in this paper. These two redundant methods are proposed to alleviate the settling requirement of the DAC circuit and to improve the operation speed of SAR ADC. Meanwhile, no extra c...

Velnacrine maleate (Mentane®) is an aminoacridine drug developed for the treatment of Alzheimer's disease. Although velnacrine maleate has not been observed to cause prominent cytotoxicity in in vitro hepatocyte cultures, this drug was associated with elevated serum levels of hepatic enzyme...

The present study assessed the safety and efficacy of the cholinesterase inhibitor, velnacrine, for treating the cognitive symptoms of Alzheimer's disease. Patients (N = 236) meeting NINCDS-ADRDA criteria for Alzheimer's disease entered a double-blind, placebo-controlled dose-ranging p...

A simple, sensitive and rapid spectrofluorimetric method to determine velnacrine, a cholinesterase inhibitor, has been developed and validated. The influence of pH, temperature, ionic strength, presence of excipients, metal ions and surfactants on the fluorescence intensity has been studied. The...

A self-tuning multi variable predictor algorithm which is capable of providing multi step prediction of a multi variable stochastic time series is presented and applied to the problem of predicting the quality of sinter produced by an iron ore sintering process. Predicted information on strength...

Chitosan was prepared by alkaline N-deacetylation of β-chitin and hydroxypropyl derivatives with different degrees of substitution (DS) were synthesized. It was characterized by Fourier transform infrared (FT-IR) and elemental analysis. The DS of hydroxypropyl chitosan (HPCS) calculated by an e...

In order to ameliorate the biocompatibility of polysulfone (PSf), sulfonated hydroxypropyl chitosan (SHPCS) was grafted from PSf membrane material by Schiff-Base reaction. The original and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectrosco...

Two hydroxypropyl chitosan HPCS samples (HPCS1 Mw 1.6 × 105, HPCS2 Mw 3.5 × 104) were prepared by the reaction of chitosan with propylene oxide under alkali conditions. The median lethal dose of the hydroxypropyl chitosan was greater than 10 g/kg for the laboratory mice. HPCS1 at the 0.1%, 1.0...

Hydroxypropyl methylcellulose (HPMC) was used as a co-emulsifier with chitosan and the whole cells of bacteriocin-producing Lactococcus lactis IO-1 (L. lactis IO-1) for the preparation of bacteria interface Pickering emulsion. The obtained emulsion exhibited a high stability against centrifugati...

Two kinds of water-soluble hydroxypropyl chitosan (HPCS) samples with different weight-average molecular weights (Mw) (HHPCS for higher Mw, 1.43×105 Da; LHPCS for lower Mw, 5.71×103 Da) were used to investigate their absorption and distribution in mice by oral administration after being labele...

Hydroxypropyl chitosan (HPCH), a water soluble derivative of chitosan, is widely considered for tissue engineering and wound healing applications due to its biocompatibility and biodegradability. Graphene oxide (GO) is a carbon-based nanomaterial which is capable of imparting desired properties ...

In this study, a series of hydroxypropyl chitosan (HPCS)/soy protein isolate (SPI) composite films (HCSFs) with different SPI contents were developed via crosslinking, solution casting, and evaporation process. Effects of the SPI content on the structure and physical properties of the HCSFs were...

Hydroxypropyl chitosan (HPCS) has recently attracted increasing attention in biomedical applications because it has enhanced water solubility, excellent biocompatibility, and better antioxidant and antibacterial activities compared with chitosan. However, HPCS doesn't meet the mechanical st...

Collagen peptide (COP) had been grafted to hydroxypropyl chitosan (HPCS) by using microbial transglutaminase (MTGase) as biocatalyst. HPCS was synthesized from chitosan and propylene oxide under alkali condition. The chemical structures of derivative were characterized by FT-IR and 1H NMR spectr...

Nisin had been grafted to hydroxypropyl chitosan (HPCS) using microbial transglutaminase (MTGase) as biocatalyst. HPCS was synthesized from chitosan and propylene oxide under alkali condition. The chemical structures of derivatives were characterized by FT-IR and 1H NMR spectroscopy. The process...

Ullmann-type reactions are becoming a major tool in medicinal chemistry. In this article, we describe the use of these Copper-catalyzed reactions with various precursors, acyl-heteroarylamines or pyrazoles of interest for pharmacomodulation. To the medicinal chemist they offer new, usually untap...