2-Amino-N′-phenylbenzamidine (1a) reacts with tetracyanoethene (TCNE) to give 2-[2-(2-aminophenyl)-5-imino-1-phenyl-1H-imidazol-4(5H)-ylidene]malononitrile (11a), 4-(phenylamino)quinazoline-2-carbonitrile (5a) and 4-imino-3-phenyl-3,4-dihydroquinazoline-2-carbonitrile (9a). By optimizing the re...

(2Z,5Z) 2-[(5-Arylidene-4-oxo-3-phenyl)-thiazolidin-2-ylidine]-2-cyano-N-arylacetamides 4a–l were stereoselectively prepared via condensation of aromatic aldehydes with 4-thiazolidinones 3a–c. The latters were obtained via electrophilic attack of phenylisothiocyanate on 2-cyano-N-arylacetamide...

The binding sites for papaverine in human intestine were studied with the radioiodinated papaverine derivative, 6,7-dimethoxy-4-(4′-amino,3′-[125I]iodobenzyl)isoquinoline ([125I]DMABI) as a probe. This drug was shown to bind to two specific binding sites in human colon membranes; one with a lo...

In rat tissues, the specific binding of 6,7-dimethoxy 4-(4'-amino, 3'(125I)iodobenzyl)-isoquinoline is distributed as follows: aorta > pancreas > liver > intestine > stomach > lung > skeletal muscle > heart > brain. In aorta and intestine 125I-DMABI is specifically covalently incorpora...

Flotation has been used in industry for more than a half century as the primary technique for upgrading phosphate. While the flotation of phosphate was inefficient when oleic acid was used alone as a collector, therefore a mixed collector of oleic acid (HOl), linoleic acid (LA) and linolenic aci...

In the basic therapy of chronic skin diseases characterized by xerosis, the local treatment is an essential strategy to reach ideal therapeutic effects. Suitable active ingredients for this aim are fatty acids, in particular linoleic acid, which is an essential component for the organization and...

The role of reagents utilised in igneous phosphate ores flotation is reviewed. Fatty acids soaps derived from different vegetable species are utilised as collectors. Less expensive species, such as rice and soybean bran oils replaced successfully the more expensive tall oil as the source for the...

Achieving high yields of 5-hydroxymethylfurfural (HMF) from carbohydrates remains a challenge today. With the aim of developing an efficient and inexpensive catalyst for the production of HMF, manganese phosphate (MnPO4) was used as the sole catalyst for the catalytic conversion of biomass-deriv...

Hydrated manganese oxide (HMO) nanoparticles were impregnated into a peanut shell-derived biochar (BC) to obtain a remarkable nanocomposite adsorbent, HMO-BC, which overcomes the technical barriers of singly applying either HMO or BC in practical heavy metal-containing wastewater treatment. HMO-...

The utilization of electrolytic manganese residue (EMR) in synergy with red mud (RM) and other solid wastes as road base materials (RBM) was investigated in this research. The chemical composition, mechanical properties, the hydration behavior, pore structure and environmental friendliness perfo...

A natural clinoptilolite in its potassium form (KNC) was modified by impregnation of hydrated metal oxides (HMO) of aluminium (III) (KAlC), iron (III) (KFeC) and manganese (IV) (KMnC) for the simultaneous ammonium and phosphate recovery from urban wastewaters. The resulting pHpzc of the HMOs on ...

We report the preparation of a porous and hierarchical manganese(III) oxide tiny nanostructures (Mn2O3 TNS) by a simple sonochemical approach. The nanocatalyst was synthesized by a bath-type ultrasound washer (Honda Electronics, W-118T) at 700 W and 300 kHz frequency. The morphology and chemical...

Comparative studies of the electrochemical reduction of 2-(o-nitrophenylthio)-acetic acid and its methyl ester in aqueous media of different acidity show that reduction of the ester in an ammoniacal buffer is the best adapted for electrosynthesis of 4-hydroxy-2H-1,4-benzothiazin-3(4H)-one. The e...

A series of compounds derived from 7-acyl-(2H)-1, 4-benzoxazin-3-(4H)-one was synthesized and evaluated for its lipid lowering actions in animal models. These of three 7-(2-methylene butyryl) 4-methyl and 2, 4 dimethyl or 2,2,4 trimethyl benzoxazinone showed very potent activity. Their hypochole...

A novel glycosyl donor, methyl (3,4,5-tri-O-acetyl-β-d-arabino-hex-2-ulopyranosyl)onate bromide, obtained in two steps from methyl β-d-arabino-hex-2-ulopyranosonate, was converted into its α-nitrophenyl glycoside, which in turn was reductively cyclized to form acetylated benzoxazinoid spirans...

2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one (8), the hitherto undescribed free hemiacetalic aglycone of a benzoxazinoid acetal glucoside naturally occurring in wheat, has been synthesized following two pathways, independently. This cyclic hydroxamic acid methyl ester proved to be very un...

Two new and efficient synthetic routes towards substituted 4H-1,4-benzoxazine derivatives were reported. The first one involves the synthesis in four steps of the 4-Boc-4H-1,4-benzoxazine and its regioselective substitution on C-3 following a lithiation–electrophilic substitution sequence. The ...

A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.

A series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones were synthesized using 2-amino-5-nitrophenol as a starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES test) and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox.). T...

A cyclic hydroxamate, 2,4-dihydroxy-7-methoxy-2H- 1,4-benzoxazin-3(4H)-one (DIMBOA), was isolated and identified from shoots of 6-day-old corn seedlings grown in the dark. From 100 g of plant tissue 100 mg of DIMBOA were isolated. This hydroxamate was very effective in catalysing the hydrolysis ...