A novel 2-pyridinone scaffold was rationally designed and synthesized based on the active anti-HIV agent 1 (LAM-trans) via an efficient method. The biological results revealed that some target compounds inhibited HIV-1 reverse transcriptase in the lower micromolar concentration range (IC50 0.089...

2(1H)-Pyrazinones were converted into various [3,4-b] sulfolene pyridinones 19–21, serving as precursors for thermolytic conversion into the corresponding 5,6-dimethylene 2(1H)-pyridinone ortho-quinodimethanes. These were trapped in situ by reaction with various dienophiles. Tethering of precur...

The tautomerizm and conformation of the 4-hydroxyquinazoline molecule were investigated, and its three tautomers (4-HQ1, 4-HQ2, 4-HQ3) and conformer of 4-HQ2 (4-HQ2A) were considered. The tautomeric and conformational equilibrium geometry of 4-hydroxyquinazoline have been studied using density f...

In common with other aza-heterocycles, 4-hydroxyquinazoline and their derivatives are important pharmacophores and versatile lead molecule used in several specific biological activities. The potency of these compounds depends on the nature and/or position of their substituents. In this paper, we...

Carboxymethyl hyaluronic acid (CMHA) with degree of substitution of 0.5 was synthesized and crosslinked by gamma-irradiation in paste-like state (highly concentrated solution) at doses of 50–100 kGy without the addition of any initiators and crosslinking agents to obtain hydrogels with differen...

As a contribution to the development of novel coumarin-oxime ether conjugates with therapeutically interesting properties, a series of coumarin-oxime ether (1a–1j) was synthesised using SN2 reaction of bromomethyl coumarins with butane-2,3-dione monoxime. Invitro anti-tuberculosis activityagain...

The investigation of the effect of various degrees of sulfonation (DS) is important for the selection and modification of hydrocarbon type membranes towards ion exchange applications. In this work, twelve kinds of sulfonated poly (ether ether ketone) membranes with different DS were prepared and...

Polymer electrolyte membrane fuel cells (PEMFC) are important in the field of renewable energy resources. Phosphoric acid doped proton conducting polymers are mainly used as polymer electrolytes. But the main problems of such electrolyte are leaching out of the phosphoric acid, flooding, low mec...

Sulfonated graphene oxide (SGO) was synthesized by direct esterification reaction between graphene oxide (GO) and hydroxylated sulfonated poly(ether ether ketone) (SPEEK-OH) and then incorporated into sulfonated polyarylene ether nitrile (SPEN) to explore the effect of varying loading on perform...

Polyoxymethylene dimethyl ethers (H3CO(CH2O)nCH3, PODEn or DMMn, n ≥ 2) with unique physical and chemical properties are a potential additive for diesel fuels, which can effectively enhance the combustion efficiency and reduce the emission of pollutants. In this work, a series of pure PODEn com...

Hydroxymethyl functionalized poly(ether ether ketone) (OHPEEK) was exploited as the separator of lithium ion battery (LIB). The stable OHPEEK backbone endows the membrane with high anti-shrinkage property (0% until 160 °C and only 18.3% at 240 °C) and high thermal stability (degradation temper...

An imidazolium functionalized poly (ether ether ketone ketone) (PEEKK-DImOH) anion exchange membrane (AEM) readily soluble in certain low-boiling-point solvents (isopropanol) is prepared. The solubility results are consistent with the results of molecular dynamics simulations. By varying the chl...

The infrared spectra of solutions of pentafluoroethane, CHF2CF3, and dimethyl ether-d6, acetone-d6, or oxirane-d4 dissolved in liquid krypton were investigated, at temperatures between 118 and 168 K. In all spectra, evidence was found for the formation of C–H⋯O hydrogen bonded complexes that ar...

In this study, poly(ether ether ketone) is first chloromethylated to improve the solubility and is later used for nonwoven membrane fabrication by electrospinning. Finally, the chloromethyl group was converted to the ethyl ether group and dibenzyl ether group in a hot alkaline solution. The abun...

In the present study, a series of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-one derivatives (4a–i) were designed and synthesized to meet the structural requirements essential for antiepileptic activity. Antiepileptic screening was perf...

Nitration of 3,4-diaminofurazan with HNO3, followed by condensation of the di(nitramine) intermediate with N,N-bis(hydroxymethyl)-N-nitroamine or N,N-bis(acetoxymethyl)-N-nitroamine in ionic liquids affords the title compound in good yield.

The novel heterocyclic system, bis[1,2,5]oxadiazolo[3,4-c:3’,4’-e]pyridazine 4,5-dioxide, was obtained along with other products in the course of oxidation of 3,3’-bi-1,2,5-oxadiazole-4,4’-diamine. This compound acts as a synthetic equivalent of 4,4’-dinitroso-3,3’-bifurazan affording bis-...

NiF2 was oxidized at ~20 °C, to NiF62− by sunlight or ultraviolet light-irradiated F2 in liquid anhydrous hydrogen fluoride (aHF) containing alkali hydrofluorides AF(HF)x. Quantitative formation of NiF62 can be achieved with strongly basic solutions (e.g., KF:HF molar ratio ~ 1:4). Li2NiF6, whi...

The hitherto unknown Na2NiF6 is obtained in an impure state by high pressure fluorination of samples prepared by the usual fluorination of “Na2NiO3”. Guinier photographs show the presence of a cubic lattice with a = 7·77 Å, and the existence of a hexagonal form with a = 5·63 Å and c = 9·0...

The infrared and Raman spectra of solid K2NiF6 was studied. All the active frequencies ν1, ν2, ν3, ν4, and ν5 belonging to the isolated ion point group (Oh) were ascertained. Several lattice modes were also found in the Raman spectrum. Force constant calculations were carried out for both t...