Parkinson's disease (PD) is characterized by the selective death of dopaminergic neurons. To avoid inconvenience of frequent administration caused by short half life and recurrence of symptoms such as tremor and bradykinesia incurred by drug elimination, a novel long-acting pramipexole tran...

Pramipexole is a dopaminergic agonist used in Parkinson's disease treatment. It is thought to exert its therapeutic and side effects through actions on dopamine D3 receptors. In a recent study, we found that at doses occupying D3 but not D2 receptors pramipexole reduced locomotion and opera...

Tetrahydrobiopterin (BH4) deficiencies are inherited neuro-metabolic disorders leading to monoamine neurotransmitters deficiency. An individualized replacement therapy with neurotransmitters precursors is necessary to restore dopaminergic and serotoninergic homeostasis. The correction of dopamin...

The purpose of the study was to improve transdermal delivery of pramipexole via nanocrystals and investigate the enhancement micro-mechanism. Pramipexole nanocrystals were prepared using wet media milling method and incorporated into carbomer gel. In vitro permeation studies through rabbit ear s...

Herein, we present development of new pH-responsive drug delivery systems for D3-dopamine receptor agonist pramipexole, based on its encapsulation in MCM-41 mesoporous silica particles. Pramipexole loaded particles were further coated with chitosan and/or sodium alginate in order to modify drug ...

A chiral liquid chromatographic method was developed for the enantiomeric resolution of Pramipexole dihydrochloride monohydrate, (S)-2-amino-4,5,6,7-tetra-hydro-6-(propylamino) benzothiazole dihydrochloride monohydrate, a dopamine agonist in bulk drugs. The enantiomers of Pramipexole dihydrochlo...

In the current study, Pramipexole dihydrochloride loaded chitosan nanoparticles (P-CNs) were prepared for Parkinson’s disease via nose to brain pathway by ionic gelation method. Optimized P-CNs with chitosan and sodium tripolyphosphate (6:1 v/v) exhibited particle size and entrapment efficiency...

The biooxidation of benzylic alcohols catalyzed by (5-hydroxymethyl)furfural oxidase (HMFO) to the corresponding benzaldehydes or benzoic acids was investigated in the presence of various organic (co)solvents. Whereas the enzyme activity decreased at elevated concentrations of water-miscible pol...

This work reports a study on the reactivity of polymeric carbon nitride (PCN) and PCN-H2O2 adduct samples for sunlight photocatalytic selective oxidation reactions. The characterization of these materials was reported in a previous paper where the reactivity towards the partial oxidation of 5-hy...

A reaction of (S)-2-benzyl-2-(α-methylbenzyl)amino-1,3-propanediol (S)-4a and 2-chloroethyl chloroformate, and the subsequent addition of DBU gave (4R,αS)-4-benzyl-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone (4R)-5a (92% de) via a diastereoselective asymmetric desymmetrization process....

Girodazole (RP 49532A) or 3-amino-1-[4-(2 amino-1H-imidazolyl]-propanol, 2HCl is an experimental antitumor compound which inhibits protein synthesis in cell cultures and in cell free systems. The compound has been evaluated for its capacity to inhibit specific assays of initiation, elongation an...

Crystal structures of the 50 S ribosomal subunit from Haloarcula marismortui complexed with two antibiotics have identified new sites at which antibiotics interact with the ribosome and inhibit protein synthesis. 13-Deoxytedanolide binds to the E site of the 50 S subunit at the same location as ...

Dechlorane Plus (DP), a chlorinated flame retardant, is increasingly reported in aquatic ecosystems worldwide. But little information is available regarding the toxicity of DP in marine organisms, especially in macroalgae. The objective of this study was to investigate effects of DP exposure on ...

Alkyl phenanthrene (A-Phen) and Dechlorane Plus (DP) are ubiquitous environmental pollutants that widely co-exist in the environment. It has been established that both A-Phen and DP elicit neurotoxicity, but the potential interactive toxicity of these contaminants is not well-known. To determine...

A comprehensive investigation into the occurrence of Dechlorane Plus (DP) in environmental samples around a DP manufacturing plant in East China was performed. The total syn-DP and anti-DP concentrations found in the soil, sediment, active air, and passive air samples were 0.50–2,315 pg/g dry w...

In an attempt to evaluate the behavior of Dechlorane plus (DP) in soil-vegetable systems, this work investigated the uptake and translocation of DP by vegetables and the dissipation of DP in soil under greenhouse and conventional conditions. To address human dietary exposure to DP, estimated die...

The food web composition, assimilation efficiency of Dechlorane Plus (DP) in food web components, and even extrinsic conditions can affect the trophic biomagnification potentials of DP isomers in food webs. Antarctica ecological system is characterized by the presence of few consumers and simple...

While flame retardant Dechlorane Plus (DP) and its dechlorinated analogs have been frequently detected in wildlife, knowledge is limited on their bioaccumulation and maternal transfer in amphibians. In the present study, the occurrence of syn- and anti-DP isomers and a DP dechlorinated compound,...

Dechlorane Plus (DP) has been detected extensively in both biotic and abiotic matrices, and stereoselective enrichment of Dechlorane Plus isomers has also been observed in organisms. In this laboratory study, Ulva pertusa were firstly exposed to known Dechlorane Plus concentrations for 21 d (upt...

Although isomer-specific bioaccumulation of dechlorane plus (DP) has been addressed in many studies, it remains unclear which factors determine this process and whether biotransformation of DP occurs in organisms. Comparative experiments were conducted in both in vivo and in ovo incubation using...