An environmentally benign and highly efficient protocol for the transamidation of non-activated carboxamides with amines using heteropolyanion-based ionic liquids as catalysts under microwave-assisted and solvent-free conditions has been developed. As evaluated by the reactions of a structurally...

The Lewis acid-catalyzed regioselective azidolysis of 2,3-three membered heterocyclic amines has been investigated. The results obtained demonstrated that using TMSN3 as a source of azide, the appropriate choice of Lewis acid allowed to obtain different regio- and stereocontrolled precursors of ...

The compound ethyl 4-hydrazinobenzoate hydrochloride (E-4HB), C9H13N2O2Cl, has been synthesized and characterized by FT-IR, 1H and 13C NMR and X-ray diffraction. The compound crystallizes as colourless plates in the triclinic space group P-1, with Z' = 2 and cell parameters a = 5.9566 (4) Å...

The present study investigated the protective effect of L-cysteine on biomarkers and peripheral nervous system in streptozotocin-induced diabetic rats. The experimental groups included sham, control, 0.1 mM cysteine treatment, and 0.2 mM cysteine treatment. Behavioral assessment, fasting glucose...

For a set of 7 selected stable intermediates and derived radicals for the formation of 1,3,6,8- and 1,3,7,9-tetrachlorodibenzo-p-dioxins from 2,4,6-trichlorophenol, energy minimum structures, total atomic spin densities ρ, harmonic vibrational wavenumbers ν˜, principal moments of inertia IA, I...

To examine the bioremediation potential of Phlebia brevispora in dioxin-contaminated soil, the fungus was inoculated into autoclaved soil that was contaminated with 2,7-dichlorodibenzo-p-dioxin (2,7-DCDD) or 1,3,6,8-tetrachlorodibenzo-p-dioxin (1,3,6,8-TCDD). Three types of soils, organic-rich s...

Cordyceps militaris was able to metabolize dichloro-, trichlorodibenzo-p-dioxin, trichlorodibenzofuran, and 3–5 ring polycyclic aromatic hydrocarbons into their corresponding hydroxides. To investigate whether C. militaris has potential for use in soil remediation, fungal mycelia and BSM contai...

The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic polychlorinated dibenzo-p-dioxin. The OH–initiated oxidation of TCDD has been studied using the density functional, canonical transition state, and canonical Rice-Ramsperger-Kassel-Marcus theories. The kinetic data were corrected ...

A recent study reported elevated levels of 1,2,8,9-tetrachlorodibenzo-p-dioxin (1,2,8,9-TCDD) in crustaceans and finfish collected from Newark Bay, New Jersey (Rappe et al., 1989). The authors suggested that the presence of this compound in biota was due to operations at a former 2,4,5-trichloro...

N-Alkyl-N-benzyloxy carbamates, 2, undergo facile intramolecular cyclization with a variety of carbon nucleophiles to give functionalized five- and six-membered protected cyclic hydroxamic acids, 3, in good to excellent yields. This method can be extended to prepare seven-membered cyclic hydroxa...

An efficient, flexible and diastereoselective synthesis of the naturally occurring pyrrolidine amino acid, (+)-morusimic acid B, has been accomplished. Starting from chiral, optically active (+)-(3S)-hydroxy butyric acid methyl ester the key steps of our synthesis are diastereoselective α-alkyl...

Three recombinant mutant hemoglobins (rHbs) of human normal adult hemoglobin (Hb A), rHb (αT67V), rHb (βS72A), and rHb (αT67V, βS72A), have been constructed to test the role of the tertiary intra-subunit H-bonds between α67T and α14W and between β72S and β15W in the cooperative oxygenati...

An increasing hemoglobin A1c (HbA1c) level portends an adverse cardiovascular prognosis; however, the association between glycemic control, platelet reactivity, and outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is unknown. We sought to investigate whether...

FS 205–397 has been designed to mimic or improve the antipyretic/analgesic profile of paracetamol but without inducing hepatic failure. FS 205–397 offers advantages over acetylsalicylic acid since it has caused no gastric lesions in rats and unlike paracetamol it produced no hepatotoxicity in ...

In an attempt to devise new antimicrobial treatments for biofilm infections, the bacterial cell–cell communication system termed quorum sensing has emerged as an attractive target. It has proven possible to intercept the communication system by synthetic non-native ligands and thereby lower the...

The polymer-sypported synthesis of a methionine-functionalized resin for new cleavage strategy and combinatorial library of homoserine lactone analogs is described. The process consists of the coupling of N-Fmoc-methionine followed by deprotection to give a free amine of methionine-functionalize...

The application of natural eutectic solvent (NDDES) in organic synthesis has received more and more attention. In this work, a green protocol for one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-b]pyridines] via three-component reactions of 1H-pyrazol-5-amin, isatin and enolizable CH activ...

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound 13a exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation. Compound ...

Enterococcus faecalis plays an important role as one of the pathogens in polymicrobial infections. We evaluated the efficacy of cefluprenam (CFLP) using a polymicrobial pyometra of a model rat. Rats were infected with a mixed intrauterine inoculation of E. faecalis plus either Bacteroides fragil...

In the present work, we reported a combined experimental and theoretical study on molecular structure and vibrational analysis of 2,6-dichlorotoluene (DCT) and 2-chloro-6-fluorotoluene (CFT). FTIR and FT-Raman spectra of the title compounds in the solid phase are recorded in the region 4000–400...