The prognosis and survival rate of prostate cancer are very poor. Previous studies have shown that miR-556-5p have emerged as important regulators in cancer cell biological processes. The role of miR-556-5p in prostate cancer remains unclear. In this study, expression of miR-556-5p in prostate c...

As is known, the employment of molecular imprinting polymer (MIP) as specific sensing materials in sensors, namely MIP-based sensors. In this contribution, we devised a MIP electrochemical sensor for the detection of variable-format conformations protein gp120. The sensor was constructed by usin...

In this study, we have investigated the preparation of rhenium-188 nitridobis(N-ethoxy-N-ethyldithiocarbamate) [188ReN(NOET)2] (NOET = Et(EtO)NCS2), analogous to the known technetium-99m radiopharmaceutical. The new 188Re complex was synthesized in good yield with a satisfactory radiochemical pu...

Reactions of CF3CF2CFCCl2 (1) with various nucleophiles such as MeO−, PhO−, NH3, n-c4H9MgBr and n-C4H9S− were studied. Contrary to a prior report [3], the addition is bidirectional and except for Pho−, nucleophiles would rather attack the CF site (path 1) than the CCL2 site (path 2), no ma...

Liquid–liquid equilibrium (LLE) data for the ternary system water + 2-methyl-1-propanol + butyl acetate and water + 2-methyl-2-propanol + butyl acetate were measured at the temperature T = (298.15 and 323.15) K and under atmospheric pressure, respectively. Both the Othmer–Tobias and Bachman eq...

In this work, densities (ρ), ultrasonic sound velocities (u) and viscosities (η) for binary mixture of tri(butyl)methylphosphonium methyl sulfate ([P4441][CH3SO4]) with N-methyl-2-pyrrolidone (NMP) were measured over the entire composition range at temperatures ranging from 293.15 to 323.15 K ...

The thermal decomposition behaviour of tris(2-methyl butyl) phosphate (T2MBP), a higher branched homologue of tri-n-butyl phosphate (TBP), which possesses the vital characteristics of a potential extractant for the processing of nuclear materials is the subject of the present work. The thermal s...

The two native forms of gonadotropin-releasing hormones (GnRH) present in goldfish, salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate gonadotropin-II (GTH-II) and growth hormone (GH) release both in vivo and in vitro. In our previous study using perifused goldfish pituitary fragments...

Production of the endogenous vasodilator nitric oxide (NO) from l-arginine by NO synthase is modulated by l-homoarginine, l-monomethylargine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Here we report on a stable isotope dilution liquid chromatography tandem m...

BackgroundLow levels of the amino acid homoarginine and parathyroid hormone (PTH) excess are both independently related to an increased risk of cardiovascular morbidity and mortality. Accumulating evidence points to a mutual interplay between homoarginine and PTH. The authors therefore aimed to ...

The cycloaddition of cyclic nitrones to methoxycarbonylmethylenecyclopropane (1) gives adducts having the methoxycarbonyl group on C-4 of the isoxazolidine ring with high regioselectivity. The thermal rearrangement of the adducts gives quinolizidinone 6 and indolizidinones 8 bearing the methoxyc...

A quantitative NMR approach is proposed for the screening of cyclodextrins with regard to their enantioselectivity as chiral mobile phase additives in column reversed-phase chromatography and capillary electrophoresis. Similarities and differences between the mechanism of enantiomeric peak-separ...

The genotoxicity study of two widely used contraceptive synthetic progestins, i.e. norgestrel and norethindrone was carried out on human lymphocyte chromosomes using chromosomal aberrations (CA), sister chromatid exchanges (SCE) and cell growth kinetics as parameters. The study was carried out b...

The chiral separation of norgestrel enantiomers using reversed-phase high-performance liquid chromatography (RP-HPLC) was studied with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as chiral mobile phase additive. The effect of mobile phase composition, concentration of HP-beta-CD and column temp...

The impact of subdermally placed ethinyl estradiol, norgestrel, and the combination of the two on cholesterol metabolism as measured by hepatic acyl:cholesterol-acyltransferase (ACAT) activity was examined in the rat model. A total of 48 rats were assigned to one of 6 groups, receiving either 0....

Nordihydroguaiaretic acid (NDGA) is a phenolic lignan and possesses antioxidant and number of properties potentially useful to man. The effect of NDGA was studied against norgestrel induced genotoxic damage, using sister chromatid exchanges (SCEs), chromosomal aberrations (CAs), mitotic index (M...

Norgestrel (NGT) is a synthetic progestin used in human and veterinary medicine. Adult female mosquitofish were exposed to NGT for 42 d at 377 ng L−1. The fin morphology and the liver transcriptome were assessed. NGT exposure increased ray 4:6 length ratio. As compared to the control, NGT treatm...

The petrogenesis of biotite granites, which may be metaluminous or peraluminous in composition, is a subject of debate. In this study, we present new zircon U-Pb geochronology and O-Hf isotopic, and whole-rock major and trace element, and Sr-Nd isotopic data for biotite granites in the Langla–L...

Shortwave infrared (SWIR, 1000–2500 nm) reflectance spectra of biotite and chlorite were investigated to establish quantitative relationships between spectral metrics and mineral chemistry, determined by electron microprobe analysis (EMPA). Samples spanning a broad range of mineral compositions...

Dating of biotite using the 40Ar/39Ar method is used extensively to determine the timing of cooling and exhumation in metamorphic rocks. Interpretations of 40Ar/39Ar dates commonly assume that 40Ar diffuses out of biotite through temperature-dependent volume diffusion, and therefore that the dat...