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Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and

Repaglinide CAS135062-02-1

Cas:135062-02-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Repaglinide Manufacturer/High quality/Best price/In stock

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Manufacturer of Repaglinide

Cas:135062-02-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Repaglinide Cas 135062-02-1 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:2-8°C Package:20g/bag, 1kg/foil bag or as you require Applic

Manufacture favorable price Repaglinide Cas 135062-02-1 with good quality

Cas:135062-02-1

Min.Order:20 Gram

FOB Price: $1.0 / 35.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Repaglinide

Cas:135062-02-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Repaglinide manufacturer with low price

Cas:135062-02-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Repaglinide

Cas:135062-02-1

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Repaglinide 135062-02-1 GMP Manufacturer

Cas:135062-02-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Repaglinide

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Repaglinide

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Repaglinide

Cas:135062-02-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Repaglinide

Cas:135062-02-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Repaglinide

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Repaglinide 135062-02-1

Cas:135062-02-1

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 135062-02-1 with best quality

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Repaglinide

Cas:135062-02-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Production Name:Repaglinide CAS NO:135062-02-1 EINECS No.:N/A Molecular Formula:C27H36N2O4 Molecular Weight:452.59 Density: 1.137g/cm3 Melting Point(℃): 129-130℃ Boiling Point(℃): 672.9°C at 760 mmHg Flash Point(℃): 360.8

Repaglinide CAS:135062-02-1

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Repaglinide Manufacturer For Treating Type 2 Diabetes

Cas:135062-02-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of Repaglinide at Factory Price

Cas:135062-02-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

High Purity Powder Pharmaceutical Intermediates Repaglinide CAS 135062-02-1

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less 8years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:dry and cool place Package:1

Topsale Repaglinide

Cas:135062-02-1

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality API Raw Material Repaglinide Pharmaceutical Intermediate Repaglinide Powder

Cas:135062-02-1

Min.Order:10 Gram

FOB Price: $0.6

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Repaglinide/ LIDE PHARMA- Factory supply / Best price

Cas:135062-02-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Repaglinide CAS: 135062-02-1 MF: C27H36N2O4 MW: 452.59 EINECS: 629-921-1 Mol File: 135062-02-1.mol Repaglinide Structure Repaglinide Chemical Properties Melting point 129-130.2 °C alpha D20 +6.97° (c

Repaglinide

Cas:135062-02-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Pharmaceutical drug Repaglinide CAS:135062-02-1

Cas:135062-02-1

Min.Order:1 Gram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Repaglinide CAS: 135062-02-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Repaglinide CAS: 135062-02-1

Cas:135062-02-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d

cas 135062-02-1 Repaglinide Chinese manufacturer

Cas:135062-02-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Prandin

Cas:135062-02-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Factory supply antidiabetic drugs powder Repaglinide

Cas:135062-02-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:135062-02-1

Cas:135062-02-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-(+)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate
147770-06-7

(S)-(+)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
With ethanol; water; sodium hydroxide Reflux;96%
With sodium hydroxide In ethanol at 60℃; for 4h;92%
With methanol; sodium hydroxide for 3h; Reflux;87.6%
C28H38N2O4

C28H38N2O4

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
With potassium hydroxide In acetonitrile for 6h; Reflux;89.9%
C34H42N2O4

C34H42N2O4

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
With ethanol; sodium hydroxide for 5h; Reflux;85.1%
piperidine
110-89-4

piperidine

trityl thiosemicarbazide resin

trityl thiosemicarbazide resin

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 64.5 g / 6 h / 220 - 225 °C
2.1: Mg; I2 / tetrahydrofuran / 1 h / 60 - 65 °C / Heating
2.2: toluene; tetrahydrofuran / 14 h / 98 - 102 °C
3.1: 68.9 g / NaBH4 / methanol / 10 - 15 °C
4.1: N-acetyl-L-glutamic acid / acetone
5.1: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
6.1: aq. NaOH / propan-2-ol / 60 - 65 °C
View Scheme
2-(piperidin-1-yl)benzonitrile
72752-52-4

2-(piperidin-1-yl)benzonitrile

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Mg; I2 / tetrahydrofuran / 1 h / 60 - 65 °C / Heating
1.2: toluene; tetrahydrofuran / 14 h / 98 - 102 °C
2.1: 68.9 g / NaBH4 / methanol / 10 - 15 °C
3.1: N-acetyl-L-glutamic acid / acetone
4.1: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
5.1: aq. NaOH / propan-2-ol / 60 - 65 °C
View Scheme
2-Chlorobenzonitrile
873-32-5

2-Chlorobenzonitrile

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 64.5 g / 6 h / 220 - 225 °C
2.1: Mg; I2 / tetrahydrofuran / 1 h / 60 - 65 °C / Heating
2.2: toluene; tetrahydrofuran / 14 h / 98 - 102 °C
3.1: 68.9 g / NaBH4 / methanol / 10 - 15 °C
4.1: N-acetyl-L-glutamic acid / acetone
5.1: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
6.1: aq. NaOH / propan-2-ol / 60 - 65 °C
View Scheme
(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine
147769-93-5

(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
2: aq. NaOH / propan-2-ol / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
2: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; pivaloyl chloride / dichloromethane / 1 h / 0 - 5 °C
1.2: 15 h / 0 - 20 °C
2.1: sodium hydroxide / ethanol / 1 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: tetramethylorthosilicate / toluene / 10 h / Inert atmosphere; Reflux
2: sodium hydroxide; ethanol / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: tetramethylorthosilicate / toluene / 11 h / Inert atmosphere; Reflux
2: sodium hydroxide; methanol / 3 h / Reflux
View Scheme
(S)-1-(2-piperidino-phenyl)-3-methyl-1-butylamine
108157-52-4

(S)-1-(2-piperidino-phenyl)-3-methyl-1-butylamine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-acetyl-L-glutamic acid / acetone
2: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
3: aq. NaOH / propan-2-ol / 60 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
3-methyl-1-[2-(piperidin-1-yl)phenyl]butan-1-imine
147769-96-8

3-methyl-1-[2-(piperidin-1-yl)phenyl]butan-1-imine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 68.9 g / NaBH4 / methanol / 10 - 15 °C
2: N-acetyl-L-glutamic acid / acetone
3: 80 percent / N,N-dicyclohexylcarbodiimide / CH2Cl2 / 20 °C
4: aq. NaOH / propan-2-ol / 60 - 65 °C
View Scheme
Multi-step reaction with 5 steps
1: 34 percent / toluene / 15 h / Ambient temperature
2: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
3: aq. HCl / 5.5 h / Heating
4: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 6 steps
1: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
2: 63 percent / Et3N, TiCl4 / toluene / Ambient temperature
3: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr
4: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
5: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
6: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
piperidine
110-89-4

piperidine

3.) methyl halide

3.) methyl halide

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 34 percent / toluene / 15 h / Ambient temperature
4: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
5: aq. HCl / 5.5 h / Heating
6: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 8 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
4: 63 percent / Et3N, TiCl4 / toluene / Ambient temperature
5: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr
6: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
7: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
8: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 8 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
4: Et3N, TiCl4 / toluene / Ambient temperature
5: 66 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 160 h / 160 °C / 150012 Torr
6: H2, aq. HCl / 10 percent Pd/C / 10 h / 50 °C / 3750.3 Torr
7: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
8: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
2-(piperidin-1-yl)benzonitrile
72752-52-4

2-(piperidin-1-yl)benzonitrile

cyclohexyl-CH2-MgX

cyclohexyl-CH2-MgX

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tetrahydrofuran; toluene / 3 h / Heating
2: 34 percent / toluene / 15 h / Ambient temperature
3: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
4: aq. HCl / 5.5 h / Heating
5: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
6: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 7 steps
1: tetrahydrofuran; toluene / 3 h / Heating
2: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
3: 63 percent / Et3N, TiCl4 / toluene / Ambient temperature
4: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr
5: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
6: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 7 steps
1: tetrahydrofuran; toluene / 3 h / Heating
2: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
3: Et3N, TiCl4 / toluene / Ambient temperature
4: 66 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 160 h / 160 °C / 150012 Torr
5: H2, aq. HCl / 10 percent Pd/C / 10 h / 50 °C / 3750.3 Torr
6: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
2-Chlorobenzonitrile
873-32-5

2-Chlorobenzonitrile

2-chloro-benzaldehyde seqtrans-oxime

2-chloro-benzaldehyde seqtrans-oxime

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 34 percent / toluene / 15 h / Ambient temperature
4: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
5: aq. HCl / 5.5 h / Heating
6: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 8 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
4: 63 percent / Et3N, TiCl4 / toluene / Ambient temperature
5: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr
6: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
7: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
8: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 8 steps
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C
2: tetrahydrofuran; toluene / 3 h / Heating
3: 4N aq. HCl / toluene; tetrahydrofuran / 20 °C
4: Et3N, TiCl4 / toluene / Ambient temperature
5: 66 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 160 h / 160 °C / 150012 Torr
6: H2, aq. HCl / 10 percent Pd/C / 10 h / 50 °C / 3750.3 Torr
7: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
8: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
2-hydroxy-p-toluic acid
50-85-1

2-hydroxy-p-toluic acid

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: K2CO3 / diethyl ether / 30 h / 150 °C
2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
4: HCl / Heating
5: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
6: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 8 steps
1: K2CO3 / diethyl ether / 30 h / 150 °C
2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
4: HCl / Heating
5: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
6: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
8: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 7 steps
1: K2CO3 / diethyl ether / 30 h / 150 °C
2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
4: HCl / Heating
5: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
6: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
ethyl 2-ethoxy-4-methyl-benzoate
88709-17-5

ethyl 2-ethoxy-4-methyl-benzoate

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
3: HCl / Heating
4: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
5: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
6: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 7 steps
1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
3: HCl / Heating
4: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
5: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 6 steps
1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
3: HCl / Heating
4: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
5: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
6: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
2-(piperidin-1-yl)benzaldehyde
34595-26-1

2-(piperidin-1-yl)benzaldehyde

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Ambient temperature
2: Ti(OiPr)4 / tetrahydrofuran; toluene / 60 h / 100 °C
3: H2, aq. HCl / 10 percent Pd/C / 5 h / 50 °C / 3750.3 Torr
4: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 - 65 °C
2.1: magnesium / tetrahydrofuran; dichloromethane / 1 h / -50 - 20 °C
3.1: hydrogenchloride / water / 20 °C
4.1: 4-methyl-morpholine; pivaloyl chloride / dichloromethane / 1 h / 0 - 5 °C
4.2: 15 h / 0 - 20 °C
5.1: sodium hydroxide / ethanol / 1 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 - 65 °C
2.1: magnesium / tetrahydrofuran; dichloromethane / 1 h / -50 - 20 °C
3.1: hydrogenchloride / water / 20 °C
4.1: 4-methyl-morpholine; pivaloyl chloride / dichloromethane / 1 h / 0 - 5 °C
4.2: 15 h / 0 - 20 °C
5.1: sodium hydroxide / ethanol / 1 h / 20 °C / Reflux
View Scheme
ethyl 4-bromomethyl-2-ethoxy-benzoate
110017-07-7

ethyl 4-bromomethyl-2-ethoxy-benzoate

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
2: HCl / Heating
3: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
4: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 6 steps
1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
2: HCl / Heating
3: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
4: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
6: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
2: HCl / Heating
3: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
4: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
ethyl 4-cyanomethyl-2-ethoxy-benzoate
99470-01-6

ethyl 4-cyanomethyl-2-ethoxy-benzoate

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: HCl / Heating
2: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
3: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: HCl / Heating
2: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
3: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: HCl / Heating
2: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
3: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
3-methyl-1-(2-piperidin-1-yl-phenyl)-butan-1-one
147770-03-4

3-methyl-1-(2-piperidin-1-yl-phenyl)-butan-1-one

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 63 percent / Et3N, TiCl4 / toluene / Ambient temperature
2: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr
3: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
4: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: Et3N, TiCl4 / toluene / Ambient temperature
2: 66 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 160 h / 160 °C / 150012 Torr
3: H2, aq. HCl / 10 percent Pd/C / 10 h / 50 °C / 3750.3 Torr
4: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
5: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
ethyl 4-(2-amino-2-oxoethyl)-2-ethoxybenzoate

ethyl 4-(2-amino-2-oxoethyl)-2-ethoxybenzoate

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
2: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
2: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
2: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
2: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate
332347-69-0

ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
2: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
2: 59 percent / N,N'-dicyclohexyl-carbodiimide / toluene / 2 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine
147769-98-0

N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. HCl / 5.5 h / Heating
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
N-acetyl-N-<3-methyl-1-(2-(1-piperidinyl)phenyl)-1-(Z)-buten-1-yl>-amine
147769-97-9

N-acetyl-N-<3-methyl-1-(2-(1-piperidinyl)phenyl)-1-(Z)-buten-1-yl>-amine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr
2: aq. HCl / 5.5 h / Heating
3: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
<2-(1-piperidinyl)phenyl>-N-<(R')-1-phenethyl>-aldimine

<2-(1-piperidinyl)phenyl>-N-<(R')-1-phenethyl>-aldimine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Ti(OiPr)4 / tetrahydrofuran; toluene / 60 h / 100 °C
2: H2, aq. HCl / 10 percent Pd/C / 5 h / 50 °C / 3750.3 Torr
3: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
N-<(S)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine
219922-07-3

N-<(S)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2, aq. HCl / 10 percent Pd/C / 5 h / 50 °C / 3750.3 Torr
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
N-<(S)-3-methyl-1-<2-(1-pieridinyl)phenyl>butyl>-N-<(S')-1-phenethyl>-amine
147770-01-2

N-<(S)-3-methyl-1-<2-(1-pieridinyl)phenyl>butyl>-N-<(S')-1-phenethyl>-amine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
N-<(R)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine
219921-97-8

N-<(R)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2, aq. HCl / 10 percent Pd/C / 10 h / 50 °C / 3750.3 Torr
2: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
3: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
isobutyl-(2-piperidino-phenyl)-N-<(R')-1-phenethyl>-ketimine

isobutyl-(2-piperidino-phenyl)-N-<(R')-1-phenethyl>-ketimine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 66 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 160 h / 160 °C / 150012 Torr
2: H2, aq. HCl / 10 percent Pd/C / 10 h / 50 °C / 3750.3 Torr
3: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
isobutyl-(2-piperidino-phenyl)-N-<(S')-1-phenethyl>-ketimine

isobutyl-(2-piperidino-phenyl)-N-<(S')-1-phenethyl>-ketimine

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr
2: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr
3: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
4: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
N-(2-piperidino-benzyl)-2-piperidino-benzaldimine

N-(2-piperidino-benzyl)-2-piperidino-benzaldimine

cycloheptyl-CH2-halide

cycloheptyl-CH2-halide

(S)-repaglinide
135062-02-1

(S)-repaglinide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) LDA / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, hexane, from -70 deg C to RT, overnight
2: HCl / 0.5 h / 0 °C
3: Ambient temperature
4: Ti(OiPr)4 / tetrahydrofuran; toluene / 60 h / 100 °C
5: H2, aq. HCl / 10 percent Pd/C / 5 h / 50 °C / 3750.3 Torr
6: 29 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature
7: 92 percent / 1N NaOH / ethanol / 4 h / 60 °C
View Scheme
1-deoxy-1-(methylamino)-D-glucitol
6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

(S)-repaglinide
135062-02-1

(S)-repaglinide

C27H36N2O4*C7H17NO5

C27H36N2O4*C7H17NO5

Conditions
ConditionsYield
With 3-methyl-1-butyl acetate In chloroform at 65℃; Temperature;95.2%
berberine chloride
633-65-8

berberine chloride

(S)-repaglinide
135062-02-1

(S)-repaglinide

repaglinide berberine

repaglinide berberine

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 60 - 70℃; pH=7 - 8;91%
4-(1-hydroxyethyl)benzyl alcohol
80463-22-5

4-(1-hydroxyethyl)benzyl alcohol

(S)-repaglinide
135062-02-1

(S)-repaglinide

repaglinide 4-[1-(hydroxyethyl)]benzoate

repaglinide 4-[1-(hydroxyethyl)]benzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;90%
1-(3-(hydroxymethyl)phenyl)ethan-1-ol
1013027-15-0

1-(3-(hydroxymethyl)phenyl)ethan-1-ol

(S)-repaglinide
135062-02-1

(S)-repaglinide

repaglinide 3-[1-(hydroxyethyl)]benzoate

repaglinide 3-[1-(hydroxyethyl)]benzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;90%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

benzaldehyde
100-52-7

benzaldehyde

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(1-(4-cyanophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(1-(4-cyanophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;87%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

aniline
62-53-3

aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(1-(4-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(1-(4-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;85%
(S)-repaglinide
135062-02-1

(S)-repaglinide

(S)-2-(3-ethoxy-4-formylphenyl)-N-(3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)acetamide

(S)-2-(3-ethoxy-4-formylphenyl)-N-(3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)acetamide

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; fac-tris(2-phenylpyridinato-N,C2')iridium(III); tris-(trimethylsilyl)silane; dimethyl dicarbonate In acetonitrile at 20℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;84%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(2-(cyclohexylamino)-2-oxo-1-p-tolylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-m-tolylbenzamide

N-(2-(cyclohexylamino)-2-oxo-1-p-tolylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-m-tolylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;83%
manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

(S)-repaglinide
135062-02-1

(S)-repaglinide

C54H74MnN4O10*2H2O

C54H74MnN4O10*2H2O

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 2h; pH=9;82%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

aniline
62-53-3

aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(2-(cyclohexylamino)-2-oxo-1-p-tolylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(2-(cyclohexylamino)-2-oxo-1-p-tolylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;82%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

(S)-repaglinide
135062-02-1

(S)-repaglinide

diethyl (2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)amino)-2-oxoethyl)phenyl)phosphonate

diethyl (2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)amino)-2-oxoethyl)phenyl)phosphonate

Conditions
ConditionsYield
With palladium diacetate; 2,2-dimethylpropanoic anhydride; triethylamine; 1,4-di(diphenylphosphino)-butane In 1,4-dioxane at 160℃; for 15h; Inert atmosphere; Schlenk technique;80%
(S)-repaglinide
135062-02-1

(S)-repaglinide

C27H35(2)HN2O4

C27H35(2)HN2O4

Conditions
ConditionsYield
With 2C11H15O2(1-)*C10H14*Ru(2+); water-d2 In 1,4-dioxane at 100℃; for 16h;80%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-chloro-aniline
106-47-8

4-chloro-aniline

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(4-chlorophenyl)-N-(1-(4-cyanophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)benzamide

N-(4-chlorophenyl)-N-(1-(4-cyanophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)benzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;80%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

benzaldehyde
100-52-7

benzaldehyde

aniline
62-53-3

aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;78%
(S)-repaglinide
135062-02-1

(S)-repaglinide

phenol
108-95-2

phenol

(S)-phenyl 4-(2-((1-(2-cyclohexylphenyl)-3-methylbutyl)amino)-2-oxoethyl)-2-ethoxybenzoate

(S)-phenyl 4-(2-((1-(2-cyclohexylphenyl)-3-methylbutyl)amino)-2-oxoethyl)-2-ethoxybenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 50℃; Inert atmosphere;77%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

aniline
62-53-3

aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(2-(cyclohexylamino)-1-(4-nitrophenyl)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(2-(cyclohexylamino)-1-(4-nitrophenyl)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;77%
(S)-1-(1-(4-isobutylphenyl)ethyl)cyclopropan-1-ol

(S)-1-(1-(4-isobutylphenyl)ethyl)cyclopropan-1-ol

(S)-repaglinide
135062-02-1

(S)-repaglinide

2-(7-ethoxy-3-((S)-3-(4-isobutylphenyl)-2-oxobutyl)-1-oxo-1,3-dihydroisobenzofuran-5-yl)-N-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)acetamide

2-(7-ethoxy-3-((S)-3-(4-isobutylphenyl)-2-oxobutyl)-1-oxo-1,3-dihydroisobenzofuran-5-yl)-N-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)acetamide

Conditions
ConditionsYield
With potassium phosphate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate In acetonitrile at 80℃; for 24h; Sealed tube; Molecular sieve;77%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

4-chloro-aniline
106-47-8

4-chloro-aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(4-chlorophenyl)-N-(2-(cyclohexylamino)-2-oxo-1-p-tolylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)benzamide

N-(4-chlorophenyl)-N-(2-(cyclohexylamino)-2-oxo-1-p-tolylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)benzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;76%
ethanethiol
75-08-1

ethanethiol

(S)-repaglinide
135062-02-1

(S)-repaglinide

repaglinide S-ethyl thioester

repaglinide S-ethyl thioester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h; Inert atmosphere;75%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

aniline
62-53-3

aniline

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(1-(4-cyanophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(1-(4-cyanophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;75%
water
7732-18-5

water

zinc(II) chloride
7646-85-7

zinc(II) chloride

(S)-repaglinide
135062-02-1

(S)-repaglinide

C54H74N4O10Zn*H2O

C54H74N4O10Zn*H2O

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 3h; pH=8;74%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

aniline
62-53-3

aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(2-(cyclohexylamino)-1-(4-methoxyphenyl)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(2-(cyclohexylamino)-1-(4-methoxyphenyl)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;74%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

benzaldehyde
100-52-7

benzaldehyde

4-chloro-aniline
106-47-8

4-chloro-aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(4-chlorophenyl)-N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)benzamide

N-(4-chlorophenyl)-N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)benzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;73%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

aniline
62-53-3

aniline

(S)-repaglinide
135062-02-1

(S)-repaglinide

N-(2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

N-(2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl)-2-ethoxy-4-(2-((S)-3-methyl-1-(2-(piperidin-1-yl)phenyl)butylamino)-2-oxoethyl)-N-phenylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;72%
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