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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Ethoxycaybonyl-3-Ethoxyphenyiaceticacid supplier in China

Cas:99469-99-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Nanjing Yuance Industry&Trade Co., Ltd.

White powder Purity 99% with competitive price Fast delivery Prompt shipment Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical Intermediates / Medicine Intermediates Port:Shanghai, Nanjing

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid, 99469-99-5

Cas:99469-99-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl 2-ethoxy-4-carboxymethylbenzoate

Cas:99469-99-5

Min.Order:1

Negotiable

Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Ethoxy-4-(ethoxycarbonyl)-benzeneacetic acid

Cas:99469-99-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1506.html Product Name 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid CAS No.

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid 99469-99-5

Cas:99469-99-5

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 99469-99-5 with best quality

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

3-Ethoxy-4-(ethoxycarbonyl)phenylacetic Acid manufacturer/supplier

Cas:99469-99-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:room temperature Package:25kg/drum Application:Repaglinide intermediate. Transportation:Express/Sea/Air Port:any port in china

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid factory price

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1,In No Less 8 years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:white to pale yellow solid Storage:dry and cool

High quality 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid 99%

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid/ LIDE PHARMA- Factory supply / Best price

Cas:99469-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3-Ethoxy-4-ethoxycarbonyl phenylacetic acidCAS: 99469-99-5

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid CAS:99469-99-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hi

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid CAS:99469-99-5

Cas:99469-99-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid

Cas:99469-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

High quality 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid with best price

Cas:99469-99-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid

Cas:99469-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Ethoxy-4-(Ethoxycarbonyl)Benzeneacetic Acid

Cas:99469-99-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3-ethoxy-4-ethoxycarbonyl-phenyl acetic acid

Cas:99469-99-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-ethoxy-4-ethoxycarbonyl-phenyl acetic acid/High quality/Best price

Cas:99469-99-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Ethoxycaybonyl-3-Ethoxyphenyiaceticacid

Cas:99469-99-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-Ethoxy-4-ethoxycarbonyl phenylacetic acid

Cas:99469-99-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate
332347-69-0

ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water pH=3; Large scale;90.5%
Stage #1: ethyl 2-ethoxy-4-ethoxycarbonylmethyl-benzoate With sodium hydroxide; water In methanol at 10 - 15℃; for 1 - 2h;
Stage #2: With hydrogenchloride In water at 0 - 5℃; pH=3 - 4;
77.8%
With sodium hydroxide In ethanol at 23 - 25℃; for 1.5h;59%
With water; sodium hydroxide In ethanol at 30℃; for 1h;
2-ethoxy-4-methylbenzoic acid
88709-18-6

2-ethoxy-4-methylbenzoic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -80 - -70℃; for 4h; Temperature;86.2%
C16H22O5

C16H22O5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water pH=3;78.1%
C17H24O5

C17H24O5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water pH=3;77.7%
carbon dioxide
124-38-9

carbon dioxide

ethyl 2-ethoxy-4-methyl-benzoate
88709-17-5

ethyl 2-ethoxy-4-methyl-benzoate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -30℃; for 0.5h;
Stage #2: ethyl 2-ethoxy-4-methyl-benzoate With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran; hexane at -75℃; for 2h;
Stage #3: carbon dioxide In tetrahydrofuran; hexane at -75 - 10℃; for 0.5h;
72.7%
Stage #1: ethyl 2-ethoxy-4-methyl-benzoate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; Inert atmosphere; Industrial scale;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -75℃; Industrial scale;
67%
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -30℃; for 0.5h;
Stage #2: ethyl 2-ethoxy-4-methyl-benzoate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran; hexane at -75℃; for 2h;
Stage #3: carbon dioxide In tetrahydrofuran; hexane at -75 - 20℃;
59.5%
Stage #1: ethyl 2-ethoxy-4-methyl-benzoate With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 10℃;
23%
ethyl 2-ethoxy-5-(2-oxo-2-(quinolin-8-ylamino)ethyl)benzoate

ethyl 2-ethoxy-5-(2-oxo-2-(quinolin-8-ylamino)ethyl)benzoate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxy-5-(2-oxo-2-(quinolin-8-ylamino)ethyl)benzoate With ozone In dichloromethane at -78℃; Inert atmosphere;
Stage #2: With copper dichloride In 1,4-dioxane; water at 100℃; for 1h; Inert atmosphere; Microwave irradiation;
42%
ethyl 4-(2-amino-2-oxoethyl)-2-ethoxybenzoate

ethyl 4-(2-amino-2-oxoethyl)-2-ethoxybenzoate

A

2-ethoxy-[4-(carboxymethyl)]benzoic acid
220438-80-2

2-ethoxy-[4-(carboxymethyl)]benzoic acid

B

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite at 35℃; for 2h;A n/a
B 39%
2-hydroxy-p-toluic acid
50-85-1

2-hydroxy-p-toluic acid

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: K2CO3 / diethyl ether / 30 h / 150 °C
2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
4: HCl / Heating
5: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
View Scheme
Multi-step reaction with 5 steps
1: K2CO3 / diethyl ether / 30 h / 150 °C
2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
4: aq. HCl / 1.5 h / 20 - 23 °C
5: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / dimethyl sulfoxide / 10.5 h / 40 °C
2.1: diisopropylamine; n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
2.2: -78 - 10 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / dimethyl sulfoxide / 11 h / 40 °C
2.1: diisopropylamine; n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
2.2: -78 - 10 °C
View Scheme
ethyl 2-ethoxy-4-methyl-benzoate
88709-17-5

ethyl 2-ethoxy-4-methyl-benzoate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
3: HCl / Heating
4: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4
2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
3: aq. HCl / 1.5 h / 20 - 23 °C
4: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
View Scheme
Multi-step reaction with 2 steps
1: dihydrogen peroxide; copper dichloride; bis(diphenylphosphino)ethylamine / tetrahydrofuran / 10 h / 15001.5 Torr / Reflux
2: hydrogenchloride / water / pH 3
View Scheme
Multi-step reaction with 2 steps
1: tert.-butylhydroperoxide; palladium dichloride; depe / tetrahydrofuran / 20 h / 15001.5 Torr / Reflux
2: hydrogenchloride / water / pH 3 / Large scale
View Scheme
ethyl 4-bromomethyl-2-ethoxy-benzoate
110017-07-7

ethyl 4-bromomethyl-2-ethoxy-benzoate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
2: HCl / Heating
3: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C
2: aq. HCl / 1.5 h / 20 - 23 °C
3: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
View Scheme
ethyl 4-cyanomethyl-2-ethoxy-benzoate
99470-01-6

ethyl 4-cyanomethyl-2-ethoxy-benzoate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / Heating
2: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: aq. HCl / 1.5 h / 20 - 23 °C
2: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C
View Scheme
ethyl 3-hydroxyphenylacetate
22446-38-4

ethyl 3-hydroxyphenylacetate

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid / 0.42 h / Reflux
1.2: 0.5 h / 0 °C
1.3: 5 h / 0 - 20 °C
2.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C
2.2: 5 h / Reflux
3.1: sodium hydroxide; water / ethanol / 1 h / 30 °C
View Scheme
3-hydroxyphenylacetic acid
621-37-4

3-hydroxyphenylacetic acid

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / 2 h / Reflux
2.1: acetic acid / 0.42 h / Reflux
2.2: 0.5 h / 0 °C
2.3: 5 h / 0 - 20 °C
3.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C
3.2: 5 h / Reflux
4.1: sodium hydroxide; water / ethanol / 1 h / 30 °C
View Scheme
C13H16O5

C13H16O5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: ozone / dichloromethane / -78 °C / Inert atmosphere
2.2: 1 h / 100 °C / Inert atmosphere; Microwave irradiation
View Scheme
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine
147769-93-5

(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine

(S)-(+)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate
147770-06-7

(S)-(+)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
Stage #1: 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid With 1,1'-carbonyldiimidazole In dichloromethane
Stage #2: (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine In dichloromethane Product distribution / selectivity;
93%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate at 0 - 20℃; for 18.5h;89.5%
With phenylboronic acid In toluene for 16 - 18h; Product distribution / selectivity; Heating / reflux;89.6%
3-oxa-8-azabicyclo[3.2.1]octane hydrochloride

3-oxa-8-azabicyclo[3.2.1]octane hydrochloride

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

ethyl 4-(2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl)-2-ethoxybenzoate

ethyl 4-(2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl)-2-ethoxybenzoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;93%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

C10H7NO2

C10H7NO2

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C66H72N6O12

C66H72N6O12

Conditions
ConditionsYield
In methanol at 20℃; for 4.5h; Ugi Condensation;90%
(S)-2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethylamine

(S)-2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethylamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

(S)-2-ethoxy-4-[2-({2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethyl}amino)-2-oxoethyl]benzoic acid ethyl ester

(S)-2-ethoxy-4-[2-({2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethyl}amino)-2-oxoethyl]benzoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid With oxalyl dichloride In toluene for 3h;
Stage #2: (S)-2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethylamine With triethylamine In water; toluene for 2h;
87.2%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

phenyl[2-(piperidin-1-yl)phenyl]methanamine
99469-98-4

phenyl[2-(piperidin-1-yl)phenyl]methanamine

ethyl 2-ethoxy-4-[N-(α-phenyl-2-piperidino-benzyl)aminocarbonylmethyl]-benzoate
99469-91-7

ethyl 2-ethoxy-4-[N-(α-phenyl-2-piperidino-benzyl)aminocarbonylmethyl]-benzoate

Conditions
ConditionsYield
87%
87%
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;77%
77%
77%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C62H74N4O10

C62H74N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 5h; Ugi Condensation;87%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

terephthalaldehyde,
623-27-8

terephthalaldehyde,

p-toluidine
106-49-0

p-toluidine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C62H74N4O10

C62H74N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 5.5h; Ugi Condensation;86%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

(S)-1-(2-piperidino-phenyl)-3-methyl-1-butylamine
108157-52-4

(S)-1-(2-piperidino-phenyl)-3-methyl-1-butylamine

ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate
108175-51-5

ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;85%
With triethylamine; triphenylphosphine In tetrachloromethane; water; ethyl acetate; acetonitrile
1-(6-chloro-2-piperidino-phenyl)-1-butylamine

1-(6-chloro-2-piperidino-phenyl)-1-butylamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

ethyl 2-ethoxy-4-[N-{1-(6-chloro-2-piperidino-phenyl)-1-butyl}-aminocarbonylmethyl]-benzoate

ethyl 2-ethoxy-4-[N-{1-(6-chloro-2-piperidino-phenyl)-1-butyl}-aminocarbonylmethyl]-benzoate

Conditions
ConditionsYield
85%
85%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

terephthalaldehyde,
623-27-8

terephthalaldehyde,

aniline
62-53-3

aniline

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

diethyl-4,4'-(2,2'-(1,1'-(1,4-phenylene)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl))bis (phenylazanediyl)bis(2-oxoethane-2,1-diyl))bis(2-ethoxybenzoate)

diethyl-4,4'-(2,2'-(1,1'-(1,4-phenylene)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl))bis (phenylazanediyl)bis(2-oxoethane-2,1-diyl))bis(2-ethoxybenzoate)

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;85%
pyrrolidine
123-75-1

pyrrolidine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

ethyl 2-ethoxy-4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)benzoate

ethyl 2-ethoxy-4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)benzoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;83%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

benzaldehyde
100-52-7

benzaldehyde

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

diethyl-4,4'-(2,2'-(1,4-phenylenebis((2-(cyclohexylamino)-2-oxo-1-sphenylethyl)azanediyl)) bis(2-oxoethane-2,1-diyl))bis(2-ethoxybenzoate)

diethyl-4,4'-(2,2'-(1,4-phenylenebis((2-(cyclohexylamino)-2-oxo-1-sphenylethyl)azanediyl)) bis(2-oxoethane-2,1-diyl))bis(2-ethoxybenzoate)

Conditions
ConditionsYield
In methanol at 20℃; for 5.15h; Ugi Condensation;83%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

terephthalaldehyde,
623-27-8

terephthalaldehyde,

4-chloro-aniline
106-47-8

4-chloro-aniline

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C60H68Cl2N4O10

C60H68Cl2N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 5h; Ugi Condensation;82%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C62H74N4O10

C62H74N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;82%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

1-(2-piperidino-phenyl)-butylamine
99469-97-3

1-(2-piperidino-phenyl)-butylamine

ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate
99469-89-3

ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;81%
With triethylamine; triphenylphosphine In tetrachloromethane; water; ethyl acetate; acetonitrile
With 1,1'-carbonyldiimidazole In tetrahydrofuran
With 1,1'-carbonyldiimidazole In tetrahydrofuran
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C60H68Cl2N4O10

C60H68Cl2N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 5.5h; Ugi Condensation;81%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

1-(5-chloro-2-piperidino-phenyl)-propylamine

1-(5-chloro-2-piperidino-phenyl)-propylamine

ethyl 2-ethoxy-4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>propyl>amino>-2-oxoethyl>-benzoate
219922-19-7

ethyl 2-ethoxy-4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>propyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
80%
80%
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;51%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

2-(5-chloro-2-piperidino-phenyl)-2-propylamine

2-(5-chloro-2-piperidino-phenyl)-2-propylamine

ethyl 2-ethoxy-4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>propyl>amino>-2-oxoethyl>-benzoate

ethyl 2-ethoxy-4-<2-<<1-<5-chloro-2-(1-piperidinyl)phenyl>propyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;80%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

1-(2-piperidino-phenyl)-heptylamine
219921-62-7

1-(2-piperidino-phenyl)-heptylamine

ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate
219922-26-6

ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>heptyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;80%
79%
79%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

terephthalaldehyde,
623-27-8

terephthalaldehyde,

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C62H74N4O10

C62H74N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;78%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C12H15(2)HO3

C12H15(2)HO3

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; 2,4,6-Triisopropylthiophenol; water-d2; 9-(2-mesityl)-10-methylacridinium perchlorate In dichloromethane at 20℃; Irradiation;78%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

(±)-2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethylamine
107362-46-9

(±)-2-phenyl-1-[2-(piperidin-1-yl)phenyl]ethylamine

ethyl 2-ethoxy-4-<2-<<2-phenyl-1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate
107362-11-8

ethyl 2-ethoxy-4-<2-<<2-phenyl-1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;72%
1-(2-piperidino-phenyl)-ethylamine
89606-11-1, 767583-77-7, 779992-28-8

1-(2-piperidino-phenyl)-ethylamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate
219922-18-6

ethyl 2-ethoxy-4-<2-<<1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile for 15h; Ambient temperature;70%
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

3-methyl-1-(2-piperidino-phenyl)-3-butenylamine glutarate

3-methyl-1-(2-piperidino-phenyl)-3-butenylamine glutarate

ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>3-buten-1-yl>amino>-2-oxoethyl>-benzoate
219922-24-4

ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>3-buten-1-yl>amino>-2-oxoethyl>-benzoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In toluene for 2h; Ambient temperature;70%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

1,4-phenylenediamine
106-50-3

1,4-phenylenediamine

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid
99469-99-5

2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

C60H68F2N4O10

C60H68F2N4O10

Conditions
ConditionsYield
In methanol at 20℃; for 6h; Ugi Condensation;70%

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