A microbore column liquid chromatographic method for the simultaneous determination of norepinephrine (NE), serotonin (5-HT), and 5-hydroxyindole-3-acetic acid (5HIAA) in microdialysis samples from rat brain is described. The method is based on precolumn derivatization of NE, 5HT, and 5HIAA with...

The concentrations of the serotonin metabolites 5-hydroxyindole-3-acetic acid (5HIAA) and 5-hydroxytryptophol (5HTOL) were determined in spot urine samples of 12 mammalian and one fish species (cat, cow, dog, ferret, golden hamster, guinea pig, horse, monkey, mouse, rabbit, rainbow trout, rat, s...

The urinary excretion patterns of the serotonin (5-hydroxytryptamine; 5-HT) metabolites 5-hydroxyindole-3-acetic acid (5-HIAA) and 5-hydroxytryptophol (5-HTOL) were examined after ingestion of bananas, a food rich in 5-HT. The bananas contained on an average 25 μg 5-HT/g pulp. Both urinary 5-HI...

5-Hydroxyindole-3-acetic acid has been determined at normal and increased levels in urine. The urine samples were filtered or centrifuged and then injected into a liquid Chromatograph containing a reversed phase column with tributyl phosphate as stationary liquid phase and an aqueous buffer + me...

Sensitive methods for the determination of deuterated and non-deuterated indole-3-acetic acid and 5-hydroxyindole-3-acetic acid by combined capillary gas chromatography—negative-ion chemical ionization mass spectrometry were developed. Indole-3-acetic and 5-hydroxyindole-3-acetic acids were con...

Udenfriend's (Sjoerdsma A, Weissbach H, Udenfriend S. J Am Med Assoc 1955; 159: 397) classical screening method for urinary 5-hydroxyindole-3-acetic acid (5-HIAA) is known to be subject to error due to food and drug interferences. Goldenberg (Goldenberg H. Clin Chem 1973; 19: 38–44) introd...

A new device combining microdialysis with electrochemical microsensor was developed. It can be applied to monitor the biomolecules in the brain for biological and pharmaceutical research. In this paper, the device was applied to simultaneously determine ascorbic acid (AA) and 5-hydroxyindole-3-a...

The urinary ratio of 5-hydroxytryptophol to 5-hydroxyindole-3-acetic acid was reported to be elevated for a period of up to 22 h following acute alcohol ingestion. Therefore, the ratio could detect continuous alcohol consumption, in what was considered to be a high-risk surgical group, on the ev...

5-Hydroxyindole-3-acetic acid (5-HIAA), an indole derivative, is the main metabolite of serotonin in the human body. We determined whether or not ultraviolet B (UVB)-activated 5-HIAA (5-HIAAUVB) affects the viability of human prostate (LnCaP and PC-3) and bladder cancer cells (TCCSUP). While 5-H...

A novel approach towards the development of biomimetic electrochemical sensors is presented. It is based on magnetic-core/porous-shell molecularly imprinted composites as recognition phase. The selected substrate is 5-hydroxyindole-3-acetic acid (5-HIAA), an urinary metabolite used as carcinoid ...

Micelle formation is an important property of surfactants. Micellar solutions of cetyltrimethylamonium bromide (CTAB) have been found to accelerate the hydrolysis of α-naphthyl acetate (α-NA) by o-iodosobenzoic acid (IBA), a strong nucleophile. Critical micelle concentration (CMC) of CTAB was ...

We explore the fluorescence quenching of 1-naphthol and 2-naphthol in halocarbon solvents by using time-correlated single-photon-counting, femtosecond IR-spectroscopy and quantum chemistry computations. We find that halocarbon solvents facilitate a de-excitation mechanism via solute-solvent elec...

Naphthols are industrial contaminants occurring widely in soils and waters. Remediation of organic pollutants can be done by chemical oxidation using persulfate. However, most research experiments testing degradation of organic pollutants have been done in ideal conditions, e.g. using a pure com...

Effects of the addition of 2-naphthol and 2-naphthol-7-sulfonate on the dilute acid pretreatment of mixed wood sawdust were investigated, respectively. Compared to 2-naphthol, 2-naphtnol-7-sulfonate was more effective to enhance delignification and facilitate the enzymatic hydrolysis. The 72 h h...

Reduced graphene oxide (rGO) is one of the most widely used carbon nanomaterials. When it is released into the environment, rGO can markedly affect the transformation of many pollutants, and change their fate and risk. In this work, the synergetic effects of rGO and Cu(II) on the oxidation of 2-...

In the present study, 1-naphthol (1-NAP) and 2-naphthol (2-NAP) were extracted from urine by magnetic solid phase extraction (MSPE) based on magnetic graphitized carbon black (M-Fe3O4@C) and analyzed by high performance liquid chromatography with ultraviolet detection (HPLC-UV). M-Fe3O4@C was fa...

A chemoselective domino annulation reaction of β-naphthols with methyl aryldiazoacetate is described. The gold catalyst promoted C–H functionalization of β-naphthols, whereas a rhodium or copper complex led to O–H insertion reactions. Consecutive intramolecular lactonization occurred after s...

Determination of free and conjugated cis-3,3,5-trimethylcyclohexanol in plasma and urineA gas chromatographic procedure was developed to determine free and conjugated cis-3,3,5-trimethylcyclohexanol in plasma and urine.The sample is extracted with dichloromethane when free cis-3,3,5-trimethylcyc...

The preparation of stable Lewis base adducts of CuL (H2L=Schiff base derived from the condensation of o-hydroxypropiophenone (OHP) and salicylhydrazide (SHZ)) is described. The N-donors bipy and bipyam ligands (bipy=2,2′-bipyridyl; bipyam=2,2′-bipyridylamine) give the complexes [Cu(OHP-SHZ)(bi...

The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are important precursors in the synthesis of ...