A key 1-β-methylcarbapenem intermediate is synthesized from a highly diastereoselective condensation between the titanium enolate of 2′-hydroxypropiophenone with 4-acetoxy-β-lactam followed by ozonolysis of the resulting ketone to the carboxylic acid.

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in hig...

A Schiff base, 2-hydroxy-benzoic acid [1-(2-hydroxy-phenyl)-propylidene]-hydrazide (H2hbpp) and its Mn(II), Cu(II) and Zn(II) complexes have been synthesized. These compounds have been characterized by different physico-chemical and spectroscopic techniques (UV–Vis, IR, NMR and ESI-Mass). The m...

The liquid phase propionylation of phenol (Ph) with propionyl chloride (PC) has been studied over zeolite H-beta, Re-Y, H-Y, mordenite, H-ZSM-5 and AlCl3 at 413 K. H-beta catalyzes the reaction to 4-hydroxypropiophenone (4-HPP), 2-hydroxypropiophenone (2-HPP) and phenylpropionate (PP) as major p...

In this study, alcohol dehydrogenase (EC 1.1.1.2) from Lactobacillus brevis and glycerol dehydrogenase (EC 1.1.1.6) from Cellulomonas sp. were used for the reduction of (S)-2-hydroxypropiophenone to (1S, 2S)- and (1R, 2S)-1-phenylpropane-1,2-diol, respectively. As both dehydrogenases belong to N...

Atroponitrile (α-phenylacrylonitrile) can be synthesized by the direct catalytic ammoxidation of α-methylstyrene. Conversions to atroponitrile of 57% per pass with a selectivity of 85% are attained using a Nb-promoted USb4.6O13.2 catalyst. Several other USboxide catalysts give similar resu...

Novel monolithic supports (MS/BVPE) were prepared by thermally initiated free radical copolymerisation of p-methylstyrene (MS) and 1,2-bis(p-vinylphenyl)ethane (BVPE). The polymer was synthesised in fused silica capillaries (80 mm × 0.2 mm and 80 mm × 0.53 mm) and in borosilicate glass columns...

The catalytic hydrogenation of olefinic aromatic hydrocarbons, such as styrene, α- and β-methylstyrene, o-, m- and p-methylstyrenes and indene in the light-oil fraction was carried out by a selective method, the aromatic rings being kept intact. Gas chromatography was employed to identify the ...

Novel monolithic capillary supports (200 μm I.D.) were prepared by polymerisation of methylstyrene (MS) and 1,2-bis(p-vinylphenyl)ethane (BVPE) as a crosslinker in the presence of inert diluents (porogens). These polymeric reversed-phases (MS/BVPE) showed excellent mechanical stability and mini...

1.1. A study was made of dimerization of styrene and α-methylstyrene with phosphoric acid at 130 to 135° resulting in the formatiion of four theoretically possible cyclic hydrocarbons: 1-methyl-3-phnylindane, 1,3-dimethyl-1-phenylindane, l,l-dimethyl-3-phnylindane and 1,1,3-trimethyl-3-phenyli...

Polystyrene and polyα-methylstyrene are thermally decomposed, and the products are measured by fluorescence spectrometry and multiphoton ionization spectrometry. The monomers are found to be major products from both the polymers, but many other chemical species, including dimers and trimers, ar...

The photocatalytic reaction in the partial oxidation of α-methylstyrene (α-MS) to acetophenone (AP) was investigated for TiO2 supported on H-ZSM-5 (H-MFI), H-mordenite (H-MOR), and H-Y-type (H-FAU) zeolites. XRD results demonstrated that the anatase was the stable phase of TiO2 supported on ze...

High yields of p-methylstyrene (PMS) were obtained by coupling toluene and acetaldehydes, then cracking the resultant 1,1-ditolylethane (DTE) to give equimolar amounts of methylstyrene and toluene. In the first step, a total DTE and ‘trimer’ yield of 98% on toluene and 93% on acetaldehyde was ...

The objective of this study was to investigate the effect of novel antimicrobial packaging materials containing poly-[2-(tertbutylamino) methylstyrene] (poly(TBAMS)) on the growth of typical spoilage and pathogenic bacteria present on meat.The antimicrobial activity of materials containing diffe...

The successful copolymerization of α-methylstyrene with conjugated dienes such as 1,3-butadiene, isoprene and/or styrene was achieved by anionic solution polymerization in hexane using formulated catalyst systems at the ceiling temperature of α-methylstyrene. This polymerization is unique, sin...

An efficient sodium dithionite (Na2S2O4)-mediated method for construction of 3-hydroxyquinolines via in situ Meinwald rearrangement/intramolecular reductive cyclization of o-nitrobenzalacetophenone oxides has been developed. The practical approach is of excellent functional group compatibility w...

Nowadays compounds showing aggregation-induced emission enhancement (AIEE) are extensively studied due to their huge range of applications in material science. AIEE and the anion recognition ability of 2-hydroxyquinoline-3-carbaldehyde (1) were explored. Unique AIEE phenomenon is observed in CH3...

An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of ...

A method for the preparation of 4-hydroxyquinoline-2,3-dicarboxylates has been developed by aza-Michael addition reaction of N-(2-aminobenzoyl)benzotriazoles with dimethyl acetylenedicarboxylate. 4-Hydroxyquinoline-2,3-dicarboxylates were obtained in moderate to good yields (53–87%).

trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil. Esterification was explored as a strategy to increase lipophilicity and biopharmaceutical properties of TAA, a highly polar tricarboxyli...