Cytosine-specific DNA methyltransferases are important enzymes in most living organisms. In prokaryotes, most DNA methyltransferases are members of the type II restriction-modification system where they methylate host DNA, thereby protecting it from digestion by the accompanying restriction endo...

Electron microscopy of some selected, vacuum-dried and rotary-shadowed, polyelectrolytic polysaccharides and glycoproteins adsorbed to mica indicates that this technique can yield reliable information about polymer conformation for chains with persistence lengths q exceeding about 10 nm. Statist...

The effect of the length and chemical composition of the side-chains in comb-like branched polysaccharides on gelation with trivalent metal ions has been studied using xanthan and xylinan (acetan) with intact and truncated side-chains.Partial or complete removal of the terminal β-d-mannose, or ...

A solids extraction method, using sonication in combination with weak anion exchange solid phase extraction, was created to extract thyroxine (T4) and thyroxine-O-β-d-glucuronide (T4-Glc) simultaneously from wastewaters and sludges, and to quantify these compounds via reversed-phase ultra-high ...

In this paper, the thermal stability of pure l-thyroxine (THY) and l-thyroxine sodium salt hydrate (THYSS) vs. two pharmaceutical solid formulations commercialized on both Romanian and European market (with a content of 100 μg, respectively 200 μg THYSS per tablet) were investigated. In order ...

An efficient synthesis of α-fluorochalcones (1,3-diphenyl-2-fluoroprop-2-en-1-one) based on the Suzuki–Miyaura palladium-catalyzed cross-coupling reaction of arylboronic acids with α-fluorocinnamoyl chlorides in the presence of Cs2CO3 in toluene is described. This approach allows the synthesi...

This paper reports a new method for fabricating two-dimensional ZnO nanorod patterns. A water soluble mixture of poly(vinyl alcohol)-N-methyl-4(4′-formylstyryl)pyridinium methosulfate acetal (PVA-Sbq) and zinc acetate (ZnA) was used as a negative photoresist to produce the desired patterns usin...

Polyphenols like caffeic acid and its phenethyl ester have been associated with potent anti-aggregating activity. Accordingly, we screened a library of polyphenols and synthetic derivatives thereof for their capacity to inhibit tau-aggregation using a thioflavin T-based fluorescence method. Our ...

A series of five 2-(2-hydroxyphenyl)oxazolo [4,5-b]pyridines (HPOP) (3a-e), where four are novel, were synthesized by a mild, one pot, phenylboronic acid-NaCN catalyzed reaction. Spectroscopic characterization and photophysical properties of these compounds are reported. Absorption and excitatio...

The electrochemical behaviour of 5-(nitrophenyl)-1,2-dithiole-3-thiones and 5-(nitrophenyl)-1,2-dithiole-3-ones was studied by cyclic voltammetry in DMF. The standard reduction potentials of 5-(p-nitrophenyl)-dithiolethione and 5-(p-nitrophenyl)-dithiolone entered into a linear correlation invol...

Highly selective and sensitive poly(vinyl chloride) (PVC) membrane electrodes based on 6-methyl-4-{[1-(2-thienyl)methylidene]amino}3-thioxo-3,4-dihydro-1,2,4-triazin-5-(2H)-one (MATDTO) as new carriers for gadolinium ion-selective electrode was reported. The membrane solutions containing PVC, o-...

Currently there are several irreversible BTK inhibitors targeting Cys481 residue under preclinical or clinical development. However, most of these inhibitors also targeted other kinases such as BMX, JAK3, and EGFR that bear the highly similar active cysteine residues. Through a structure-based d...

The molecular structure of a thioamide derivative ethyl 2-{[(Z)3-(4-chlorophenyl)-3-hydroxy-2-propene-1-thione] amino} acetate was determined by X-ray diffraction. The proton NMR (1H NMR), Fourier Transform Infra-Red (FT-IR) and Fourier Transform Raman (FT-Raman) spectra of the compound were rec...

4-(3-(thiophen-2-yl)-9H-carbazol-9-yl)benzaldehyde (TPCBZ) was synthesized under microwave irradiation with auto generated pressure (at 130.0 °C) and characterized by 1H NMR, 13C NMR, Mass and FTIR spectroscopy, thin-layer chromatography (TLC), and elemental analyses. Here, a thin-layer of TPCB...

Nicorandil, an antianginal and potassium channel opener agent, has different useful impacts on cardiovascular and respiratory systems. Its effect against silicosis has not been discussed yet, therefore, this is an attempt to decide whether nicorandil can reduce silica-induced lung injury in rats...

SummaryWe demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice. Treatment with live P. distasonis (LPD) dramatically altered the bile acid profile with elevated lithocholic...

Altered mitochondrial oxidation increases vulnerability to cardiac ischemia/reperfusion (I/R) injury in metabolic disorders. However, the metabolic signaling responsible for the dysfunction remains partly unknown. We sought to test whether or not hypoxic succinate accumulation could inhibit pyru...

α-Tocopheryl succinate (α-TOS) is a very promising anticancer agent; however, the mechanism of its action and the role of the succinic moiety in biological activity still remains unclear. This paper, presents the first determination of the X-ray structure of α-TOS and 2,2,5,7,8-pentamethylchr...

Herein, a renewable and flexible UV-shielding biocomposite film was obtained by poly(butylene succinate) (PBS) and lignin. A strategy of reactive interfacial compatibilization was developed in order to improve the miscibility of lignin with PBS. Firstly, lignin was modified by maleic anhydride, ...

Aspergillus fumigatus strain 76T-3 formed clear zones on agar plates containing emulsified polyhydroxybutyrate (PHB), polyethylene succinate (PES), polybutylene succinate (PBS), polycaprolactone (PCL), or polylactide (PLA). The strain grew well at 40 °C in Sabouraud Dextrose Broth. Solution-cas...