Yttria stabilized zirconia (YSZ) particles were used for the replacement of amalgam alloy in Miracle Mix. The mechanical properties of YSZ–glass ionomer cements were investigated after 1 day, 1 week and 1 month storage in distilled water. Miracle Mix was used as a control and Fuji IX GP acted a...

Moringa oleifera and Moringa stenopetala are grown in Malawi in different agro-ecological zones. Moringa oleifera is the most widely cultivated pan-tropical species of a monogeneric family, the Moringaceae, regarded as versatile because of its ability to provide edible food, oil and purify water...

The recognition of vegetation changes induced by volcanic eruption is particularly important for paleoenvironmental studies in volcanic regions. In this study, we examined the molecular and stable carbon isotopic compositions (δ13C) of sedimentary leaf wax n-alkanoic acids from Lake Yamanaka at...

Cardiovascular disease imposes substantial burdens of morbidity and mortality that increase with population aging. Estimating cardiometabolic risk accurately and expediently is challenging, and no single biomarker is satisfactory; hence, we investigated the potential of serum activin A for this ...

Understanding regulators of folliculogenesis remains limited in the domestic dog (Canis familiaris), which challenges our ability to develop in vitro follicle culture systems for canid genome rescue efforts. Here, we investigated the influence of activin on dog follicle development and survival,...

As one of the members of the transforming growth factor-β (TGF-β) superfamily, activin A plays an important role in regulating follicular development and oocyte maturation. Pentraxin 3 (PTX3) is the key component that promotes the process of cumulus expansion during mammalian ovulation. At pre...

Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Fox...

The highly invasive and metastatic properties of ovarian cancer make it the leading cause of death among gynecological cancers. Elevated levels of activin A and its receptors have been found in ovarian tumors and are associated with reduced survival in ovarian cancer patients. The role of activi...

The synthesis and pharmacological characterisation of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in PtII complexes are described. Six out of eleven new PtII complexes showed a significant cytotoxic effect on NCI-H460 lung cancer cell line with EC50 values between 1.1 and 0.115 m...

Schistosomiasis is a major public health problem worldwide, especially in poor communities. Praziquantel is currently the only drug available to treat schistosomiasis and it shows low efficacy against schistosomula and juveniles stages of Schistosoma mansoni, allowing lower cure rate in areas wi...

[n-Bu4N]VO3 or a combination of vanadium complexes with some additives, as chloride salts or amines, are attractive and effective co-catalysts for aerobic oxidation of alcohols with dioxygen catalyzed by N-hydroxyphthalimide (NHPI). The role of the additives relates to the formation of more labi...

The design, synthesis and biological activity of a series of novel non-covalent D-Phe-Pro-Arg motif-based thrombin inhibitors incorporating 4,5,6,7-tetrahydrobenzothiazol-2-amine as a novel arginine surrogate are described. Compound 9, the most potent in the series of thrombin inhibitors, exhibi...

Recently we have reported the effect of (S)-6-aryl urea/thiourea substituted-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent anti-leukemic agents. To elucidate further the Structure Activity Relationship (SAR) studies on the anti-leukemic activity of (S)-2,6-diamino-4,5,6,7-tetr...

A series of mono and dicationic new 2-anilinobenzimidazole carboxamidines were prepared in a four step process starting from 4-amino-3-nitrobenzonitrile and corresponding o-phenylenediamines. Their antiparasitic activity against Plasmodium falciparum (P. falciparum) and Trypanosoma brucei rhodes...

CGS 15943 (0.1–10 mg/kg, IP) dose-dependently increased the locomotor activity of rats to the same extent as caffeine (1.0–100 mg/kg, IP) did and was approximately 26 times more potent than caffeine. N-Ethylcarboxamidoadenosine (0.001–0.01 mg/kg, SC), an analog of adenosine, dose-dependently ...

The adenosine A2 receptor antagonist CGS 15943 (0.1 mg/kg, i.p.) was tested for cerebroprotective activity in a gerbil stroke model. CGS 15943 markedly reduced stroke injury assessed by locomotor activity monitoring and by histopathological measurement of hippocampal CA1 pyramidal cell injury. I...

9-Chloro-2-(2-furyl)[1,2,4]triazolol[1,5-c]quinazolin-5-amine (CGS 15943), like caffeine, is an antagonist at adenosine A1 and A2A receptors and a behavioral stimulant in animals. The two drugs have overlapping discriminative effects. Enhancement of dopamine-mediated neurotransmission appears to...

1.1. 2-Fluoroputrescine has a high affinity for spermidine synthase (Km 12μ M) and obeys normal Michaelis-Menten kinetics.2.2. The only product of the spermidine synthase-catalysed aminopropylation of 2-fluoroputrescine is 6-fluorospermidine. Formation of the isomerie 7-fluorospermidine could n...

A new radiolabeled analog of putrescine, 18F labeled 2-fluoroputrescine, has been prepared as a potential in vivo imaging agent for prostate and prostate derived tumors. The radiosynthesis yielded 1.5–4.5 mCi amounts of the 18F labeled putrescine analog (1–3% yields at end-of-synthesis), with ...

O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is the most promising radio-labeled amino acid tracer for brain tumor imaging due to the limitation of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and L-methyl-[11C]methionine (11C-MET). However, it has some limitations in radiosynthesis and related qu...