Propyl caffeate has the highest antioxidant capacity in the caffeate alkyl esters family, but industrial production of propyl caffeate is hindered by low yields using either the chemical or enzymatic catalysis method. To set up a high-yield process for obtaining propyl caffeate, a novel chemoenz...

The chemopreventive and antineoplastic activities of caffeic acid derivatives are highly dependent on the chemical structures and cancer cell types. The objective of the present study was to investigate the cytotoxicity of bornyl caffeate and the underlying molecular mechanisms in rat pheochromo...

BackgroundCaffeate derivatives have been reported to exhibit antioxidant, anti-inflammatory, and anticancer activities. To reveal the cytotoxic and apoptotic effects of caffeate derivatives, we studied the effects of octyl, phenylpropyl, and decyl caffeates on cell growth and apoptosis in A549 h...

Today, continuous processing is regarded as an effective on-demand production technique of pharmaceuticals. Homemade microreactors packed with immobilized lipase under continuous-flow conditions were first applied to tailor the production of high-value caffeic acid phenethyl ester (CAPE) from me...

AimsPhenethyl caffeate benzoxanthene lignan (PCBL) is a synthetic compound with DNA interacting, antiangiogenic, antiproliferative and tumor cell death inducing abilities. Though PCBL exhibits the qualities of a prospective antitumor agent, the basic mechanism of PCBL induced cell death remains ...

Caffeic acid phenethyl ester (CAPE) is a rare natural ingredient with several biological activity, but the industrial production of CAPE using lipase-catalyzed esterification of caffeic acid (CA) and 2-phenylethanol (PE) in ionic liquids is hindered by low substrate concentrations and a long rea...

A double mutant of rat trypsinogen (Asp189Ser, ΔAsp223) was constructed by site-directed mutagenesis. The recombinant protein was produced in Escherichia coli under the control of a periplasmic expression vector. The purified and enterokinase-activated enzyme was characterized by synthetic fluo...

Several protein transport processes in the cell are mediated by signal sequence peptides located at the N-terminal side of the mature protein sequence. To date, the specific interaction and the stability of these peptides at the amphipathic interface of biological membranes and the relevance of ...

Molecular hybridization is a ligand based drug design approach is well known recent medicinal chemistry to design anti-parasitic agents. In the present study, we have designed a series of (1-phenyl-9H-pyrido [3,4-b]indol-3-yl) (4-phenylpiperazin-1-yl)methanone derivatives using molecular hybridi...

Various diseases are related to epigenetic modifications. Histone deacetylases (HDACs) and histone acetyl transferases (HATs) determine the pattern of histone acetylation, and thus are involved in the regulation of gene expression. First generation histone deacetylase inhibitors (HDACi) are unse...

Various tetrahydro-β-carboline-3-carboxylic acids (THβC-3-COOH) are identified in commercial foods and drinks by GC-MS. Positive identification of 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) is demonstrated in soy and tobasco sauces, wine, beer, wine vinegar, cider, orang...

The acid-catalyzed Pictet–Spengler reaction of d-tryptophan methyl ester with piperonal in acetic acid has been reported, the best stereoselectivity (cis/trans = 92:8) was obtained with benzoic acid as the catalyst. The Pictet–Spengler reaction of d-tryptophan methyl ester hydrochloride with p...

The synthesis and in vitro anticancer activity of novel β-carbolines is reported. New tryptamines have been prepared via hetero-Diels-Alder reaction of nitrosoalkenes with indoles and used to prepare functionalized β-carbolines by the Pictet-Spengler approach. These included 6-substituted-β-c...

2-Deoxy-l-ribose (2-deoxy-l-erythro-pentose) and 2-deoxy-d-xylose (2-deoxy-d-threo-pentose) were synthesized from 2-deoxy-d-galactose (2-deoxy-d-lyxo-hexose) and 2-deoxy-d-glucose (2-deoxy-d-arabino-hexose), respectively. Conversion of the 2-deoxy-d-hexoses to the methyl 2-deoxy-d-hexofuranoside...

To look for a way to improve the fastness properties of disperse dyes on PU fibers, six diurethane/diester tethered azo disperse dyes were prepared and applied to the dyeing of polyurethane fibers. Their detailed adsorption behaviors including the dyeing rate, build-up properties, surface-adsorb...

Low cost activated carbon was prepared from the press-cake residue of Jatropha curcas L. The effectiveness of this activated carbon and its modified forms (chemical and thermal activation) was evaluated for methylene blue (MB) dye removal from aqueous solution. Adsorption experiments were conduc...

Stereoselective synthesis of pseudopeptides 4, 5, 8, 9, 13 and 14, incorporating 2,6-diamino-4-methylen-1,7-heptanedioic acid residue, has been accomplished starting from the l-valine derived chiral synthon 1. The absolute configuration of new stereocentres was assigned on the basis of 1H NMR sp...

The photoaquation of the title compound [cis-Cr(phen)2CL+2] has been studied using high performance liquid chromatography. Both monoaquo [cis-Cr(phen)2Cl(OH2)2+2] and diaquo [cis-Cr(phen)2(OH2)3+2] products are formed, and the quantum efficiency for the loss of starting material in Tris buffer (...

The kinetics of the bromide interchange and base hydrolysis of trans-(Rh(tn)2Cl2)+, (tn=propane-1,3-diamine) have been studied. For the bromide interchange the observed pseudo first order rate constant is independent of bromide ion concentration up to 0.2 mol dm−3, whereas for the base hydrolysi...

Studies on the aquation of dichlorobis(substituted biguanide)rhodium(III) complexes were carried out in aqueous and aqueous methanol media by conductometric method. The release of chlorides in all the complexes takes place in a steppe manner and rates of each step were determined by a graphical ...