A new diketopyrrolopyrrole-based fluorescent dye 1,4-diketo-2,5-dibutyl-3,6-bis(4- (carbazol-N-yl)phenyl)pyrrolo[3,4-c]pyrrole (DPPCZ) was synthesized and characterized. DPPCZ with donor–π–acceptor–π–donor motif exhibited large and solvent-dependent two-photon absorption cross sections (δ...

A regioselective synthesis of the title 1-bromo-4-phenyl-tetrahydro-7-amino-benzocyclohepten-6-one 2 has been pursued and develop in order to allow a large scale synthesis of this highly potent and selective APN inhibitor (Ki 60 pM). The pivotal step in this approach was the desymmetrization of ...

A simple synthesis of novel mono-, bis- and poly{6-(1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines} is reported. The formation of the target compounds was achieved by the reaction of 2-bromo-1-(5-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone with the appropriate aminotriazolethiol or by t...

The N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. ...

A new aroyl hydrazone, N-2-hydroxy-4-methoxybenzaldehyde-N′-4-nitrobenzoyl hydrazone (H2L) and its mixed ligand Cu(II) complex [CuLpy] [py, pyridine] have been prepared. The ligand is characterized by elemental analysis, electronic, infrared and NMR spectral studies and the complex by electroni...

Enantiospecific syntheses of (6R,7S,8aR)-6,7-dihydroxy-indolizidine (3) and (6R,7R,8S,8aR)-6,7,8-trihydroxy-indolizidine (4) from methyl 2-azido-4,6-O-benzylidene-2-deoxy-α-D-altropyranoside (7) are reported. The two synthetic indolizidines (3) and (4) have been tested against a wide range of e...

The structure of 1-formyl-3-phenyl-5-(4-isopropylphenyl)-2-pyrazoline synthesized as single crystal was investigated by FTIR, NMR, XRD. Experimental data were complemented by quantum mechanical calculations. XRD data show that the compound crystallizes in the triclinic system (P−1) via trans iso...

A novel electrochemical sensor has been developed for levofloxacin (LEV), by coating a glassy carbon electrode (GCE) with a film of poly (L-Cysteine)@Au [email protected] graphene oxide. Cyclic voltammetry, electrochemical impedance spectroscopy, UV–Vis spectroscopy, FT-IR spectroscopy and elec...

Levofloxacin (LF) is a frequently detected fluoroquinolone in surface water, and permanganate (MnO4−) is a commonly used oxidant in drinking water treatment. This study investigated the impact of humic acid (HA) on LF degradation by aqueous MnO4− from both kinetic and mechanistic aspects. In the...

Levofloxacin (LVFX), a broad-spectrum antibacterial agent from the fluoroquinolone family, is universally prescribed with antipyretics, including paracetamol (APAP) analogs. In this study, a new drug-drug cocrystal of LVFX and an APAP analog was developed using a grinding and heating approach. A...

Adsorption of antibiotic levofloxacin from aqueous solution to humic acid treated zeolite has been studied. The equilibrium isotherm model was calculated and the site energy distribution was determined. Within the test range (initial concentration 5.5–67 mg/L, pH 2–12), adsorption performance ...

The phytotoxicity and degradation of ofloxacin (OFX) in duckweed Spirodela polyrhiza based system was estimated in this study. For that, OFX was added in an environmentally relevant range (0.01–1.0 mg L−1) in medium (Hoagland nutrient) and toxicity biomarkers, i.e. changes in plant biomass, rel...

A hydrodynamic cavitation mixer (HCM) was introduced in the supercritical fluid assisted atomization (SAA) process to improve mass transfer. SAA-HCM resulted in a more homogenous primary droplet and, as a consequence, narrower particle size distributions. Levofloxacin hydrochloride (LH) being se...

The present work represents synthesis of a novel Bi3O4Cl/BiOCl heterostructure using precipitation method and detailed characterization of the composite using FT-IR, XRD, FESEM, TEM, BET and EDX techniques. The photocatalytic activity of as-prepared Bi3O4Cl/BiOCl heterostructure was evaluated un...

A kind of Co-Fe Prussian blue analogues (Co-Fe PBAs), cobalt hexacyanoferrate Co3[Fe(CN)6]2, and graphene oxide (GO) were combined to synthesize magnetically separable Co-Fe [email protected] nanocomposites through a simple two-step hydrothermal method. The crystalline structure, morphology and ...

Three novel acetate and formate ammonium salts of N-(2-hydroxyethyl)-ethylenediamine (Hydeten) were synthesized as room temperature ionic liquids (RTILs) {2-(2-hydroxy ethylamino)-ethanaminium formate (IL1a), 2-amino-N-(2-hydroxyethyl)-ethanaminium formate (IL1b), and 2-(2-hydroxyethylamino)-eth...

SummaryObjectiveThe Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) was developed to assess voice quality. The aim of this study was to develop a Turkish adaptation of CAPE-V and to evaluate the reliability and validity of the Turkish version.

The defining feature of the Cape Cod algorithm in current literature is its assumption of a constant loss ratio over accident periods. This is a highly simplifying assumption relative to the chain ladder model which, in effect, allows loss ratio to vary freely over accident period.Much of the li...

Facing acute water challenges, the City of Cape Town has to reconcile the goal of building resilience to increasingly pronounced climate change impacts, including drought, with the persistent need to deliver equitable services and to achieve socially and environmentally just outcomes. In so doin...

SummarySummary objectiveThe purpose of this study was to assure a reliable and valid European Portuguese (EP) version of Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V). This resulted in the second EP version of CAPE-V (II EP CAPE-V), with permission granted by American Speech-Languag...