This study investigates the influence of PM10 from remote sources on PM10 episodes over the city of Cape Town. For the study, we analysed observation data from Cape Town's air quality monitoring stations as well as high-resolution simulation data from the Weather Research and Forecasting mo...

The Permian Cape Fold Belt (CFB) of South Africa forms part of a major orogenic belt that originally extended from Argentina, across southern Africa and into Antarctica. The CFB is dominated by complexly folded and faulted rocks of the siliciclastic Cape Supergroup that were deposited in the Cap...

Although the parcel method and the convective available potential energy (CAPE) are widely used to predict the strength and height of convection, they ignore the pressure perturbation and fail to explain strong updrafts observed in tropical cyclones and hurricanes without CAPE, or deep, strong w...

This study describes the application of capillary electrophoresis (CE) to the analysis of ebrotidine and its metabolites as an alternative analytical technique to liquid chromatography. Comparison between UV–diode array spectroscopy and mass spectrometry (MS) using an ion-trap system with elect...

1.1. The effect of a new antiulcer agent, ebrotidine, on the synthesis and secretion of sulfomucin in gastric mucosa was investigated. Rat gastric mucosal segments were incubated in DMEM containing [3H]proline, [3H]glucosamine and [35S]Na2SO4 as markers for mucin synthesis, glycosylation and sul...

1.1. H. pylori infection causes the loss of mucus coat continuity and its patchy appearance. Here, we present evidence that the bacterium, through its cell wall lipopolysaccharide, disrupts the interaction between mucin and its mucosal receptor, and that ebrotidine is capable of counteracting th...

1.1. Gastric mucus from duodenal ulcer patients before and following therapy with a new antiulcer agent, ebrotidine, at 400, 600 and 800 mg dose was examined for changes in the physicochemical qualities and anti-H. pylori activity.2.2. The results of physical measurements revealed that successfu...

Ebrotidine is a new H2-receptor antagonist with powerful antisecretory activity, demonstrated gastroprotection and the ability to inhibit protease and lipase activities of Helicobacter pylori. As a tool in the clinical pharmacokinetic study of ebrotidine, an analytical method for the simultaneou...

1.1. The effect of ebrotidine, a new antiulcer agent, on the activity of mucus degrading of protease and lipase enzymes elaborated by Helicobacter pylori was investigated.2.2. In the absence of ebrotidine, the H. pylori protease caused extensive degradation of gastric mucus protein, while free f...

1.1. The effect of antiulcer agent, ebrotidine, on the expression of gastric mucosal laminin receptor during ulcer healing was investigated.2.2. Rats with acetic acid-induced chronic gastric ulcers were treated twice daily for 14 consecutive days either with ebrotidine at 100 mg/kg or placebo, a...

1. Rat gastric mucosal cells, subjected to phospholipid labeling by incubating the cell suspension in DMEM with [3H]choline, were exposed to different concentrations (0-150 μM) of H2-receptor antagonists, ebrotidine and ranitidine, and the phospholipid secretory responses were evaluated.2. In t...

Background/Aim: Ebrotidine is a new H2-receptor antagonist marketed in Spain in early 1997 and withdrawn in July 1998. We report 11 cases of acute liver injury related to ebrotidine and submitted to a Regional Registry of Hepatotoxicity between June 1997 and August 1998.Methods: In all cases a s...

Ebrotidine and its potential metabolites were determined by micellar electrokinetic capillary chromatography (MECC) using sodium dodecylsulfate (SDS) as surfactant. The influences of buffer composition, SDS concentration and addition of a neutral surfactant such as Brij 35 were studied. A 40 mM ...

The synthesis of new 4-amino substituted pyrazolo[3,4-d]pyrimidines along with their activity in cell-free enzymatic assays on Src and Abl tyrosine kinases is reported. Some compounds emerged as good dual inhibitors of the two enzymes, showed antiproliferative effects on two Bcr–Abl positive le...

Synthesis of novel 4-unsubstituted dihydropyrimidines (DPs) was performed. Subsequently, a variety of 4-unsubstituted 1,4(3,4)-DPs with amino moieties at position-2 were obtained in excellent yields by activation of position-2 owing to regioselective alkoxycarbonylation at position-3 of the DP s...

A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one with various one carbon donors. The starting material 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one was syn...

The photodecarboxylation of 2-(2′-carboxymethoxy-5′-methylphenyl)-benzotriazole was investigated under direct excitation in various solvents. This reaction leads cleanly to 2-(2′-methoxy-5′-methylphenyl)-benzotriazole which is phototransformed afterwards. The quantum yields of phototransform...

A series of {bis[N,N’N′-(2-ethyl-6-methylphenyl)imino]-1,2-dimethylethane}dibromonickels have been synthesized and characterized. The crystal structures of representative chiral ligand, bis[N,N’N′-(2-ethyl-6-methyl-4-s-phenethylphenyl)imino]-1,2-dimethylethane (S,R)–2a and its chiral comple...

To visualize fatty acid amide hydrolase (FAAH) in brain in vivo, we developed a novel positron emission tomography (PET) ligand N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[11C]methylphenyl)thiazol-2-yl]-1-carboxamide ([11C]DFMC, [11C]1). DFMC (1) was shown to have high binding affi...

The lipase B from Candida antarctica (CAL-B)-catalyzed the enantioselective resolution of N-(2-ethyl-6-methylphenyl)alanine from the corresponding racemic methyl ester is investigated. However, the enantioselectivity of CAL-B towards the resolution is not high enough to obtain enantiomerically p...