Bis(fluorenyl)dimethylzirconium has been prepared from fluorene, methyllithium and zirconium tetrachloride by a new and convenient route. The compound was characterized by elemental analysis, proton NMR and mass spectrometry. Photolysis of bis(fluorenyl)dimethylzirconium in solution leads to cle...

A completely nickel-aluminum-copper (Ni-Al-Cu) layer was obtained through thermal diffusion process on a nickel-aluminum-bronze (NAB) substrate. The cumulative mass loss of the NAB alloy during the cavitation erosion tests was about 6.4 times and 5.5 times as large as that of the Ni-Al-Cu layer ...

Electroless deposition of aluminum using room temperature ionic liquids (RTIL) and liquid reducing agents is extremely water sensitive and has only been successful in glove boxes with deposition on copper or glass substrates. We have successfully brought the deposition out of the glove box using...

Continuous carbon fiber-reinforced aluminum-nickel matrix composites were manufactured by immersion of an interlayered layup design of aluminum foils, nickel mesh strips and nickel-coated carbon fibers in an aluminum melt at 900 °C for 15 s. Samples with and without fibers were compared. Scanni...

Neutral aqueous electrolytes are known to promote corrosion of carbon coated aluminum current collectors used in electrochemical capacitors, limiting their applications on energy storage devices. Alternatively to the standard electrode manufacturing recipe, we have grown multi-walled carbon nano...

In this investigation, cast nickel aluminum bronze (NAB) was subjected to friction stir processing (FSP). The mechanical properties and the cavitation erosion behavior of the as-cast and FSP NAB alloy were investigated. The results showed that the initial microstructure of the as-cast NAB transf...

Spectrin, a major component of the membrane skeletal meshwork of metazoan cells, is implicated to associate with membrane domains and is known to act as a scaffold for stabilization and activation of different signalling modules. We have studied the effect of GM1 (monosialotetrahexosyl gangliosi...

Spectrins are a group of cytoskeletal proteins which participate in many important cellular functions. It has been suggested that loss of spectrin isoforms may be associated with tumorigenesis of lymphoma, leukemia, gastric cancer and hepatocellular carcinoma (HCC). We recently reported that βI...

An effective intramolecular Michael cyclization and intramolecular SN2′ cyclization is described for constructing the tricyclic framework of the natural mycotoxins brevianamides A,B.

A potentially bio-mimetic Diels–Alder cyclization to construct the bicyclo[2.2.2] ring system common to the paraherquamides, marcfortines, sclerotamides, brevianamides, VM55599, and asperparaline is reported. Epi-deoxybrevianamide E (22) is converted into the corresponding lactim ether (23) and...

A [13C]labeled hypothetical intermediate metabolite that was invoked by Birch in the biogenesis of brevianamides A and B has been synthesized and used in a biosynthetic feeding experiment. No incorporation of this substance was evident nor could it be detected in culture extracts of the producin...

Brevianamide A, and its photolysis product brevianamide D from Penicillium viridicatum, and ochratoxin A from P. verrucosum were assayed against two lepidopterous pests, Spodoptera frugiperda and Heliothis virescens. Ochratoxin A and brevianamide A were potent antifeedants against larvae of both...

A concise synthesis of brevianamide B has been accomplished using a biomimetically-inspired intramolecular Diels–Alder reaction to diastereoselectively form the characteristic bicyclo[2.2.2]diazooctane core.

The synthesis of the prenylated indole alkaloids, malbrancheamide B and brevianamide B have been accomplished, starting with a prenylated proline derivative created using the Seebach ‘self-reproduction of chirality’ method, and using a cationic cascade sequence as the key step to form late-sta...

The exponential growth in energy consumption has led to a renewed interest in the development of alternatives to fossil fuels. Between the unconventional resources that may help to meet this energy demand, nuclear fusion has arisen as a promising source, which has given way to an unprecedented i...

A simple and fast reaction between 12-molybdophosphate heteropoly anion and the polymethine dye Astra Phloxine was used for the development of a new SIA method for the determination of orthophosphate. The suggested method has higher sensitivity and a broader calibration range than existing SIA m...

Within the past year, it has become apparent, in connection with its use on automatic flow cytometers, that the quality of commercially available Alcian Blue has significantly declined. A homologous series of alkylated (C1–C7) Astra Blue quaternary ammonium halides was prepared, characterized, ...

Identifying the critical process parameters (CPPs) of a complex drug product manufacture and the associated impact on critical quality attributes (CQAs) is essential to the development and quality control of both new and generic drugs. AmBisome, a liposomal amphotericin B (AMB) macrolide antibio...

Molecular simulation was adopted to investigate and compare the water-channel performance of a common Amphotericin B_Ergosterol (AmBEr) model with that of two hydrophobically modified Amphotericin B_Ergosterol (C3deOAmBEr) models. Structural characteristics and transport performances were also e...

EObjectiveThe aim of this meta-analysis was to assess the efficacy and safety of treatment with echinocandins compared with amphotericin B in paediatric patients with invasive candidiasis.