(5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. We report herein an improved synthesis of this compound and analogs (5a-C-methyl, pentyl, nonyl and ...

Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the...

Aconitine and its structurally-related diterpenoid alkaloids have been shown to interact differentially with neuronal voltage-dependent sodium channels, which was suggested to be responsible for their analgesia and toxicity. Bulleyaconitine A (BAA) is an aconitine analogue and has been prescribe...

A novel sorbent for magnetic solid-phase extraction by self-assembling of organosulfur compound, (bis-(2,4,4-trimethylpentyl)-dithiophosphinic acid), onto the silver-coated Fe3O4 nanoparticles was introduced. Due to the formation of covalent bond of SAg, the new coating on the silver surface was...

In this study, La3+, Ce3+ and Sm3+ were removed from a solid matrix using supercritical CO2 which contained bis(2,4,4-trimethylpentyl)dithiophosphinic acid (Cyanex 301) as a chelating agent and tributylphosphate (TBP) as a co-extractant. The fractional factorial design, 25−1, was employed to opt...

The present study aims to decontaminate arsenic from metallurgical processing solutions. The extraction profile of As(V)/(III) along with some associated metal ions like Se(IV), Ga(III), Sb(III), Bi(III), Ni(II), Cu(II), Hg(II) and Pb(II) in bis(2,4,4-trimethylpentyl)dithiophsophinic acid (Cyane...

Sorption of Am3+ and Eu3+ onto an extraction chromatographic resin material, prepared by impregnating purified bis(2,4,4-trimethylpentyl)dithiophosphinic acid (commercially available as Cyanex 301) into Chromosorb W, was investigated. Separation factor (S.F. = Kd,Am/Kd,Eu) values tend to increas...

The synergistic solvent extraction of samarium (III) with mixtures of sec-octylphenoxy acetic acid (CA12, H2A2) and bis(2,4,4-trimethylpentyl) dithiophosphinic acid (Cyanex301, H2B2) in n-heptane has been investigated from chloride medium. The methods of slope analysis and constant mole are used...

The paper presents data on zinc extraction from sulfate solutions with bis(2,4,4-trimethylpentyl)dithiophosphinic acid (HR, trade mark CYANEX 301) diluted with nonane and kerosene in the absence and in the presence of electron-donor additives (L). Trialkyl amine (TAA), trialkyl phosphine oxide (...

The paper presents data on cobalt extraction from sulfate solutions with bis(2,4,4-trimethylpentyl)dithiophosphinic acid (HR) diluted with nonane and kerosene in the presence of electron donor additives (L). Trioctyl amine (TOA), trialkyl amine (TAA), trioctyl phosphine oxide (TOPO), trialkyl ph...

The paper presents data on cobalt extraction from sulfate solutions with bis(2,4,4-trimethylpentyl)dithiophosphinic acid (HR, trade mark CYANEX 301) diluted with nonane and toluene. Using the cobalt distribution data, electronic spectroscopy and IR-spectroscopy methods, it was concluded that cob...

Concentrations of heavy metals namely Cu, Zn, Pb, Ni, Mn and Cd were detected in tissue of six freshwater fish species (Hampala microlepidota, Barbonymus schwanenfeldii, Mystacoleucus marginatus, Hemibagrus nemurus, Cyclocheilicthys apogon and Oreochromis niloticus from Galas River and Beranang ...

Uridine 5′-diphosphate-glucuronic acid (UDP-GlcA) and UDP-galacturonic acid (UDP-GalA), the unique carboxylic acid-formed sugar nucleotides, are key precursors involved in the biosynthesis of numerous cell components. Limited availability of those components has been hindering the development o...

The aim of the present work was to compare the effect of ultralow oxygen (ULO) with dynamic controlled atmosphere (DCA) and controlled atmosphere (CA) on the post storage quality of ‘Royal Gala’ and ‘Galaxy’ apples after long-term storage. Two experiments were carried out with ‘Royal Gala’...

In 2006, two 0.3 ha orchard trials were established at two sites (Dressel farm in Southeastern New York State and VandeWalle farm in Western New York State) to compare two tree types (feathered trees and bench-grafted trees) on five rootstocks [three Geneva® rootstocks (G.11, G.16, G.41) with on...

In 2006, two 1-ha orchard trials were established at each of two sites (Dressel farm in Southeastern New York State and VandeWalle farm in Western New York State) to compare seven Geneva® rootstocks (‘CG.4210’, ‘G.11’, ‘G.16’, ‘G.41’, ‘G.30’, ‘G.210’, and ‘G.935’) with one Budagovs...

Fruit thinning is the most important yet difficult practice that drives orchard profitability. High labor costs and difficulty to improve return bloom by hand thinning have left chemical thinning as the main method used by growers. However, unpredictability and safety/environment concerns regard...

A α-helical GALA peptide (WEAALAEALAEALAEHLAEALAEALEALAA) has been found to possess dual functions: a pH-dependent inducer of endosomal escape, and a ligand that targets lung endothelium. In the present study, the flexibility of GALA was improved by modifying the edge with polyethylene glycol l...

ABSTRACTApple production in Southern Brazil has been increasing along the past decade, and part of this was due to the introduction of more adapted dwarfing rootstocks and consequently increased tree density in the orchards. Looking for obtaining early beariness, the use of branched nursery tree...

Environmental factors like air temperature directly affect the pollen tube growth which in turn can regulate fruit set and crop load in apple. The estimation of the pollen tube length and the time when the pollen tube reaches the stylar base is useful information for managing fruit load, site se...