Polymerizable N-methacrylamino m-BOC-type 1,1-dimethyl-2-methacrylmethanamido-ethoxy-carbonyl- and 1,1-dimethyl-3-methacrylmethanamido-butoxy-carbonyl group, derived from the corresponding t-alkohols have been developed as acid labile aminoprotecting groups. The synthesis of monomeric and polyme...

The title compound (S)-α-methylserinal acetonide has been efficiently prepared from (S)-α-methylserine, which is readily available in enantiomerically pure form by Curtius rearrangement of α,α-dialkyl 2-cyanoesters obtained by diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfam...

The design and synthesis of a new series of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives, built on the structure of 1-ethyl-3-(6-nitrobenzoxazol-2-yl)-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4(1H)-quinolone, are described. These compounds provide new scaffold for the discovery of Topois...

A metal free synthesis of S-alkyl thioesters, which does not involve alkylthiol or thiocarboxylic acid as sulfur source is disclosed. The process involves first an acylation at the nitrogen of the readily available N-(2-aminophenyl)-4-methyl-thiazolin-2-thione, second an alkylation at sulfur of ...

We developed Wnt/β-catenin inhibitors by identifying 13 number of 3-arylethynyl-substituted pyrido[2,3,-b]pyrazine derivatives that were able to inhibit the Wnt/β-catenin signal pathway and cancer cell proliferation. In the optimization process, a series of 2,3,6-trisubstituted pyrido[2,3,-b]p...

The oxidation of 4,8-diamino-4H,8H-bisfurazano[3,4-b:3’,4’-e]pyrazine 1 with positive halogen reagents and related oxidants afforded a stable nitrogen-centered radical, bisfurazano[3,4-b:3’,4’-e]pyrazine biradical 4; tetrazene 2 was a probable intermediate

By applying the method of chemical oxidative polymerization with FeCl3 the copolymer of 2,3-bis-tridecylthieno[3,4-b]-pyrazine (TTP) and 3-dodecylthiophene (DDT) was synthesized. The copolymer was characterized by the UV–VIS, FT-IR, 1H-NMR, 13C-NMR and EPR spectroscopy. The product is soluble i...

Alternating low bandgap π-conjugated polymers consisting of 5,7-dithien-2-yl-thieno[3-4-b]pyrazine and phenylene linked directly (PP-DTTP) and by ethynylene linkages (PPE-DTTP) have been prepared in high yields by Suzuki coupling polymerization and Sonogashira condensation, respectively. Thin f...

The enantio-differentiating hydrogenations of a series of alkyl 3-oxobutanoates were carried out at the temperatures ranging from 333 to 393 K over the (R,R)-tartaric acid-modified Ni catalyst prepared from commercially available Ni powder to achieve high enantiomeric excesses of 91-94%. It was ...

A series of aliphatic polyesters based on tartaric acid and its derivatives were synthesized starting from naturally occurring L-tartaric acid. The hydroxyl groups of the tartaric acid derivatives were first protected and the polyesters were synthesized by bulk and solution polycondensation meth...

When investigating the Sharpless epoxidation of enol-protected 4-hydroxy-1,2-cyclopentanediones, the ability of the asymmetric Ti(OiPr)4/tartaric ester complex to discriminate between enantiomeric epoxides formed in situ was discovered, leading to the epoxide opening reaction of only one enantio...

Publisher SummaryThis chapter describes the physicochemical properties, synthesis, stability, biopharmaceutical aspects, acute toxicities of, as well as analytical methods for dibenzepin hydrochloride. The drug shows remarkable histaminolytic and anti-anaphylactic effects and this antidepressant...

Both enantiomers of 1,1-diethoxyethyl(aminomethyl)phosphinates were prepared through chromatographic separation of a diastereomeric mixture derived from (S)-phenylethylamine and 1,1-diethoxyethyl-H-phosphinate. The individual enantiomer was transformed into α-substituted α-amino-H-phosphinate ...

The kinetic resolution of 1,1-diethoxyethyl(hydroxymethyl)phosphinate possessing chirality at the phosphorus atom was achieved via a lipase-catalyzed acylation. The product was transformed into the corresponding imine, which in turn is a useful starting material for the preparation of phosphinyl...

The vertical distribution of 21 elements (K, Ca, Ti, Fe, Mn, Cr, Ni, Cu, Zn, Ga, As, Se, Br, Rb, Sr, Y, Zr, Pb, Th, U, Hg) in four Italian soils derived from volcanic materials has been investigated. Most of the elements, and in particular lithogenic ones, show little enrichment/depletion indica...

The 230Th238U disequilibrium method has been applied to the potassic volcanic series of Vico (Latium, Central Italy). The 3 main events of the recent volcanic activity have been dated using whole-rock isochrons. The lava flows of the main cone were erupted between 260 and 180 ky. Pyroclastic flo...

The palynological study of the Vico maar lacustrine sequence (Italy) is realized from the correlation of three drillholes. The time span covers a period from the end of Oxygen Isotope Substage 5b till the beginning of Stage 1 (from ca. 90 to ca. 10 ka BP).At the base of the pollen diagram (polle...

We examine the role of physical volcanological processes including eruption style (magmatic versus phreatomagmatic) as well as transport and depositional processes (pyroclastic fall versus pyroclastic flow) in promoting the ideal hydrologic conditions necessary for large scale, homogeneous, post...

A small monomictic, volcanic lake, Lago di Vico in Central Italy, was studied intensively for one calendar year 1992–1993 for its water quality and phytoplankton. The results were compared with those obtained 20 years before. A significant increase in nutrients such as orthophosphates and nitra...

Post-orogenic magmatism in Italy took place during the Plio-Pleistocene. Alkaline ultrapotassic magmas and sub-alkaline magmas were erupted from closely-spaced volcanoes throughout the central part of Italy. Therefore, central Italy is one of the best site to study the relationship between calc-...