The conversion of the hydrazides of trityl amino acids and trityl peptides into the corresponding azides was found to proceed, under carefully selected conditions, without significant loss of the trityl group in spite of the sensitivity of the trityl nitrogen bond toward acidic reagents. Based o...

Stem cell homing, namely the recruitment of mesenchymal stem cells (MSCs) to injured tissues, is highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic peptide sequences on magnesium-doped (Mg-doped) hydroxyapatite (HA) may regulate the homing of...

An ion trap/ion mobility/time-of-flight mass spectrometry technique has been used to measure collision cross sections for 660 peptide ions generated by tryptic digestion of 34 common proteins. Measured cross sections have been compiled into a database that contains peptide molecular weight and s...

The C-terminal part (residues 106–171) of sheep κ-casein, called caseinoglycopeptide (CGP), inhibits thrombin- and collagen-induced platelet aggregation in a dose-dependent manner (mean inhibitory concentration (IC50) 215 μM and 100 μM, respectively). An enzymatic hydrolysate of CGP was frac...

This study describes the extraction and characterization of a platelet aggregation inhibitory peptide from Inonotus obliquus. Ethanol extract from I. obliquus ASI 74006 mycelia showed the highest platelet aggregation inhibitory activity (81.2%). The maximum platelet aggregation inhibitory activi...

In adult humans, after milk or yogurt ingestion, many peptides derived from αs1, β or κ-caseins were detected in stomach, including the κ-caseinoglycopeptide, an inhibitor of platelet aggregation. Smaller peptides derived from casein and lactoferrin were recovered from duodenum. Two long pep...

In this study we used micro liquid chromatography coupled to time-of-flight mass spectrometry (microLC–TOF-MS) for separation and identification of bioactive peptides in a yogurt marketed as an antihypertensive functional food. An appropriate sample clean-up using solid-phase extraction (SPE) a...

A soy protein hydrolysate was found to inhibit rat platelet aggregation induced by ADP, an aggregating agent. To find out its principal antiplatelet peptide(s), the soy protein hydrolysate was separated successively by gel filtration chromatography, reverse-phase HPLC, and cation exchange HPLC. ...

The high resolving power of a Hyper D cation-exchange column was evaluated to achieve the separation of small cationic bioactive peptides derived from tryptic digest of κ-casein: MAIPPKK (pI = 9.9), MAIPPKK (pI = 10.5), KNQDK (pI = 9.6) and NQDK (pI = 6.35). The influence of pH (1.5–6), gradie...

An undecapeptide (residues 106–116 of cow κ-casein) is known to inhibit human platelet aggregation and fibrinogen binding through inhibition of the interaction between the fibrinogen γ-chain C-terminus and αIIbβ3. This was due to structural homologies with the fibrinogen γ-chain C-terminal...

BackgroundPancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity.

Based on the self-assembly properties of vapreotide acetate (Vap), one kind of novel vapreotide acetate‑gold nanoflowers (Vap-AuNFs) was fabricated for the first time by biomimetic mineralization method using Vap as a template. The Vap-AuNFs possessed anisotropic structure with a large absorptio...

Vapreotide acetate (Vap) was used as a biotemplate to synthesize silver nanocages through direct co-incubation of a AgNO3 solution, following by reduction using fresh NaBH4. The characterized vapreotide-templated silver nanocages (Vap-AgNCs) presented a wide and red shifted absorption band with ...

Condensation of 2-methyl-1-pyrroline with chloroacetone or 3-chloro-2-butanone using LDA in THF afforded novel 2-(3-hydroxy-2-methyl-1-alkenyl)-1-pyrrolines via a peculiar reaction mechanism instead of the anticipated 2-(3-oxobutyl)-1-pyrrolines. The intermediacy of 2-(2,3-epoxy-2-methylalkyl)-1...

The natural acylphloroglucinol myrtucommulone A (1) inhibits microsomal prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), and induces apoptosis of cancer cells. Starting from 1 as lead, 28 analogues were synthesized following a straightforward modular strategy with high yielding con...

2,4,6-Trihydroxy-, 2,4,6-trihydroxy-5-methyl-, and 2,4,5,6-tetrahydroxy-substituted 3-(3-phenylpropionyl)benzaldehydes were efficiently synthesized. The first two compounds showed bactericidal activity for Pseudoperonospora cubersis.

The reaction of CuCl2·2H2O with Schiff base ligand, 4-[(2-hydroxy-3-methoxybenzylidene)amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3-one] (hmdpH), in 1:1 molar ratio led to a novel and unprecedented oxo-bridged polymeric copper (II) complex, [Cu(μ-O) (hmdp)]n. The complex was isolated as crystallin...

Maslinic acid (1) and oleanolic acid (2) were isolated from Olea europaea L. under ultra-sonication conditions with large amounts (8.5 and 3.4 mg/g DW, respectively). Copper-catalyzed microwave-assisted 1,3-dipolar cycloaddition reactions between natural pentacyclic triterpenoid-alkyne derivativ...

A simple and efficient method for the synthesis of a series of 6,7-dihydro-3H-pyrano[4,3-c]isoxazol-3-one derivatives starting from 5-carboalkoxy-2,3-dihydropyranone (5-CDHPs) has been developed. Pyranoisoxazolones 10a-j, dihydronaphthopyran-4-one (DHNPs) class of natural product 12b and 12c and...

Carbon capture, utilization and sequestration technology is effective for carbon emissions reduction. The development of new absorbent seems to be one of the core components of carbon capture technology. In this paper, three esters, methyl heptanoate, ethyl hexanoate and methyl benzoate, were se...