In this work, the molecular recognition of dimethomorph by disulfide bridged β–cyclodextrin (SS–β–CD) was studied by UV spectroscopy, 2D NMR, and molecular modeling. The results indicated that the SS–β–CD/dimethomorph was more stable than β–CD/dimethomorph, which is ascribed to the fac...

The objective of this study was to evaluate the toxicity of the fungicide dimethomorph to soil microbial activity and the earthworm Eisenia fetida. Multiple biomarkers, namely, four soil enzymes (urease, dehydrogenase, invertase, and acid phosphatase), four earthworm biochemical indices (dismuta...

Phytophthora parasitica is an important oomycete that causes disease in a variety of plants, dimethomorph fungicides being specific for oomycetes. The aim of this study was to use RNA-seq to rapidly discover the mechanism by which dimethomorph acts in the treatment of P. parasitica. We found tha...

Type 1 diabetes mellitus (DM) is a metabolic disorder associated with impaired carbohydrate metabolism. We present a promising bioinspired approach against type 1 DM using yeast microcapsule (YMC). The glucan component in the outer shell of baker's yeast undergoes receptor-mediated uptake b...

Subcutaneous insulin delivery serves as the major treatment for the ever-increasing spread of type II diabetes worldwide. However, long-term exposure to insulin results in local aggregates at the site of injection. This therapeutic concern accentuates the need to develop newer effective excipien...

AimsThe present report aimed to clarify the clinical characteristics in a girl at the age of 12 and her mother with partial lipodystrophy and Type A insulin resistance syndrome.

L’insuline est une hormone à la fois plurielle et singulière qui, à côté de ses effets bénéfiques bien connus (stimulation de l’utilisation du glucose), peut avoir également des effets délétères : stimulation de la lipogenèse et de la mitogenèse. La séquence des acides aminés de ...

Insulin-related compounds (IRCs), which originate during the expression and purification of human insulin using recombinant Escherichia coli, were purified and identified. We investigated the identity of IRCs and their origin. We also presented methods for inhibiting IRC formation. The strains u...

The LC methods for related proteins prescribed in the European Pharmacopoeia monographs for insulins and insulin analogues are very similar and present some drawbacks including long run time and low resolution. LC to UHPLC-UV geometrical transfer was attempted to overcome such drawbacks. With th...

Earlier studies have disclosed that leucinostatin A, a hydrophobic nonapeptide antibiotic, assumes an α-helical secondary structure in nonpolar environments. The present report demonstrates that the peptide acts as a weak ionophore facilitating the transport of mono-and divalent cations through...

Acremonium sp. occurs as an endophyte in European yew (Taxus baccata). It produces a series of peptide antifungal-anticancer agents known as the leucinostatins. Leucinostatin A is especially active against the oomycetous—plant pathogenic fungus—Pythium ultimum with an effective 1 day 50% inhib...

Background: Yew species (Taxus spp.) throughout the world are hosts to hundreds, or perhaps thousands, of endophytic organisms. Most commonly, these organisms are fungi, living in a commensal or a symbiotic relationship with their host plant, so the plants exhibit little or no outward evidence t...

A series of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides (3a–19a; 3b–6b) were synthesized in good yield and evaluated for their anticonvulsant and antioxidant activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data ...

Multicomponent, one-pot, highly efficient, indium trifluoride (InF3) catalytic synthesis of 2-(naphthalen-1-yl)-4,5-diphenyl-1H-imidazole under solvent-free condition is reported. Characterization of imidazole has been carried out by spectral techniques. The synthesized phosphated imidazole (PI)...

A novel (2E)-1-(5-chlorothiophen-2-yl)-3-(naphthalen-2-yl)prop-2-en-1-one [C17H11ClOS] compound has been synthesized and its structure has been characterized by FT-IR, Raman and single-crystal X-ray diffraction techniques. The isomers, optimized geometrical parameters, normal mode frequencies an...

1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols and related compounds were synthesized and evaluated for inhibition of aldosterone synthase (CYP11B2), a potential target for cardiovascular diseases associated with elevated plasma aldosterone levels like congestive heart failure and myocardial ...

The newly synthesized Schiff base compound, (Z)-N-(naphthalen-2-yl)-1-(5-nitrothiophen-2-yl)methanimine, C15H10N2O2S, was characterized by IR, UV–Vis and X-ray diffraction technique. All of the theoretical calculations have been calculated at the LSDA, BVP86, B3LYP and B3PW91 levels of the dens...

In this work, nanocrystalline thin films of 2,3-naphthalocyanine (NPC) were successfully deposited by a thermal evaporation technique at room temperature under high vacuum (∼10−4 Pa). The crystal structure and surface morphology were measured using X-ray diffraction (XRD) and scanning electron ...

In this work, a near infrared (NIR) sensitive molecule, Tin(II)2,3-naphthalocyanine (SnNc) was characterized by different techniques. UV–Vis spectroscopy and cyclic voltammetry were performed in order to determine the absorption spectrum, the highest occupied molecular orbital (HOMO) and the lo...

Vacuum deposited tin(II)2,3-naphthalocyanine (SnNc) crystalline thin films were produced. The structural properties of the thin films were characterized using Fourier transform infrared spectroscopy (FTIR), which reveals traces of organic compounds within the as-deposited films. Surface morpholo...